Interferon-alpha in tumor immunity and immunotherapy

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Prognostic Factors Analysis of 17,600 Melanoma Patients: Validation of the American Joint Committee on Cancer Melanoma Staging System

2001 • 2,365 citations

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

1999 • 2,255 citations

Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.

1996 • 2,073 citations

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Type I Interferons Potently Enhance Humoral Immunity and Can Promote Isotype Switching by Stimulating Dendritic Cells In Vivo

2001 • 942 citations

High- and Low-Dose Interferon Alfa-2b in High-Risk Melanoma: First Analysis of Intergroup Trial E1690/S9111/C9190

2000 • 923 citations

Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?

1992 • 794 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Type I Interferons Keep Activated T Cells Alive

1999 • 769 citations

The Orderly Progression of Melanoma Nodal Metastases

1994 • 755 citations

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia

2000 • 679 citations

Type I Interferon as a Powerful Adjuvant for Monocyte-Derived Dendritic Cell Development and Activity in Vitro and in Hu-Pbl-Scid Mice

2000 • 650 citations

Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells

1998 • 610 citations

Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside.

1994 • 522 citations

Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons.

1998 • 486 citations

Chronic Myelogenous Leukemia: Biology and Therapy

1999 • 483 citations

Role of interferons and other cytokines in the regulation of the immune response

1995 • 462 citations

A new American Joint Committee on Cancer staging system for cutaneous melanoma

2000 • 438 citations

Cancer vaccines

1998 • 422 citations

Prolongation of Survival in Metastatic Melanoma After Active Specific Immunotherapy With a New Polyvalent Melanoma Vaccine

1992 • 410 citations

Adjuvant interferon alfa-2a treatment in resected primary stage II cutaneous melanoma. Austrian Malignant Melanoma Cooperative Group.

1998 • 366 citations

Type I Interferon-mediated Stimulation of T Cells by CpG DNA

1998 • 361 citations

Tumor infiltrating lymphocytes in lymph node melanoma metastases: a histopathologic prognostic indicator and an expression of local immune response.

1996 • 319 citations

Mechanism of the Antitumour Effect of Interferon in Mice

1972 • 317 citations

The neglected role of type I interferon in the T-cell response: implications for its clinical use

1996 • 306 citations

Selective Lymphadenectomy: Emerging Role for Lymphatic Mapping and Sentinel Node Biopsy in the Management of Early Stage Melanoma

1993 • 276 citations

Interferon- Activates Multiple STAT Proteins and Upregulates Proliferation-Associated IL-2R, c-myc, and pim-1 Genes in Human T Cells

1999 • 273 citations

Interferon-α and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells

1998 • 271 citations

The Type I Interferon Receptor: Structure, Function, and Evolution of a Family Business

1999 • 257 citations

Randomized, surgical adjuvant clinical trial of recombinant interferon alfa-2a in selected patients with malignant melanoma.

1995 • 253 citations

Cyclophosphamide induces type I interferon and augments the number of CD44hi T lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancer

2000 • 196 citations

Regulation by interferon alpha of immunoglobulin isotype selection and lymphokine production in mice.

1991 • 193 citations

Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-alpha.

1998 • 179 citations

Cytokines, tumour-cell death and immunogenicity: a question of choice

1997 • 168 citations

Melan-A/MART-1_51–73represents an immunogenic HLA-DR4-restricted epitope recognized by melanoma-reactive CD4⁺T cells

2000 • 160 citations

Importance of cyclophosphamide-induced bystander effect on T cells for a successful tumor eradication in response to adoptive immunotherapy in mice.

1998 • 160 citations

High-Dose Interferon Alfa-2b Does Not Diminish Antibody Response to GM2 Vaccination in Patients With Resected Melanoma: Results of the Multicenter Eastern Cooperative Oncology Group Phase II Trial E2696

2001 • 143 citations

Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia

2000 • 136 citations

Principles and Practice of the Biologic Therapy of Cancer

2000 • 134 citations

Autologous Human Monocyte-Derived Dendritic Cells Genetically Modified to Express Melanoma Antigens Elicit Primary Cytotoxic T Cell Responses In Vitro: Enhancement by Cotransfection of Genes Encoding the Th1-Biasing Cytokines IL-12 and IFN-α

1998 • 125 citations

Injection of mice with antibody to interferon renders peritoneal macrophages permissive for vesicular stomatitis virus and encephalomyocarditis virus.

1984 • 124 citations

A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon α

1999 • 116 citations

Low Levels of Interferon‐α Induce CD86 (B7.2) Expression and Accelerates Dendritic Cell Maturation from Human Peripheral Blood Mononuclear Cells

1999 • 115 citations

Antitumor effects of interferon in mice injected with interferon‐sensitive and interferon‐resistant friend leukemia cells. I.

1982 • 112 citations

Injection of mice with antibody to interferon enhances the growth of transplantable murine tumors.

1983 • 94 citations

Tumour-infiltrating lymphocytes in metastatic malignant melanoma and response to interferon alpha treatment

1996 • 89 citations

IFN-alpha 1 gene expression into a metastatic murine adenocarcinoma (TS/A) results in CD8+ T cell-mediated tumor rejection and development of antitumor immunity. Comparative studies with IFN-gamma-producing TS/A cells.

1994 • 87 citations

Ex-vivo gene therapy using cytokine-transduced tumor vaccines: molecular and clinical pharmacology.

1998 • 80 citations

The Philadelphia chromosome translocation a paradigm for understanding leukemia

1990 • 77 citations

IFN-α-Expressing Tumor Cells Enhance Generation and Promote Survival of Tumor-Specific CTLs

2000 • 74 citations

Gene therapy of cancer with interferon: lessons from tumor models and perspectives for clinical applications

2000 • 67 citations

Alpha 1-interferon gene transfer into metastatic Friend leukemia cells abrogated tumorigenicity in immunocompetent mice: antitumor therapy by means of interferon-producing cells.

1993 • 65 citations

The Philadelphia chromosome translocation a paradigm for understanding leukemia

1990 • 65 citations

Antitumor effects of interferon in mice injected with interferon‐sensitive and interferon‐resistant friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously

1983 • 64 citations

Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant friend leukemia cells. II. Role of host mechanisms

1982 • 63 citations

Increased expression of human monocyte HLA-DR antigens and Fc gamma receptors in response to human interferon in vivo.

1983 • 59 citations

Interferon alpha in combination with GM-CSF induces the differentiation of leukaemic antigen-presenting cells that have the capacity to stimulate a specific anti-leukaemic cytotoxic T-cell response from patients with chronic myeloid leukaemia

2000 • 58 citations

Evaluation of efficacy of adjuvant rIFN-alfa-2a in melanoma patients with regional nodal metastases (abstract)

1995 • 57 citations

HIV-1-Specific CTL Responses Primed In Vitro by Blood-Derived Dendritic Cells and Th1-Biasing Cytokines

1999 • 54 citations

Interferon-alpha (IFN-α) stimulates anti-melanoma cytotoxic T lymphocyte (CTL) generation in mixed lymphocyte tumour cultures (MLTC)

2000 • 52 citations

Clonal heterogeneity of dendritic cells derived from patients with chronic myeloid leukemia and enhancement of their T-cells stimulatory activity by IFN-α

1999 • 52 citations

The induction of in vivo proliferation of long-lived CD44hi CD8+ T cells after the injection of tumor cells expressing IFN-alpha1 into syngeneic mice.

1998 • 50 citations

Interferon treatment markedly inhibits the development of tumor metastases in the liver and spleen and increases survival time of mice after intravenous inoculation of friend erythroleukemia cells

1988 • 46 citations

GM-CSF can improve the cytogenetic response obtained with interferon-alpha therapy in patients with chronic myelogenous leukemia

1998 • 45 citations

Nonviral InterferonαGene Therapy Inhibits Growth of Established Tumors by Eliciting a Systemic Immune Response

1998 • 45 citations

Effect of IFN-α on Tumor-Infiltrating Mononuclear Cells and Regressive Changes in Metastatic Malignant Melanoma

1998 • 43 citations

Synergistic role of type I interferons in the induction of protective cytotoxic T lymphocytes

1995 • 42 citations

Anti‐tumor effects of interferon in mice injected with interferon‐sensitive and interferon‐resistant friend erythroleukemia cells. VIII. Role of the immune system in the inhibition of visceral metastases

1990 • 42 citations

Interferon-α gene therapy for cancer: retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models

1997 • 41 citations

IFN‐α₁ gene transfection completely abolishes the tumorigenicity of murine B16 melanoma cells in allogeneic DBA/2 mice and decreases their tumorigenicity in syngeneic C57BL/6 mice

1995 • 41 citations

Interferon (IFN)-β Gene Transfer into TS/A Adenocarcinoma Cells and Comparison with IFN-α

1999 • 40 citations

Interferons in the Therapy of Solid Tumors

1994 • 39 citations

Host humoral and cellular immune mechanisms in the continued suppression of Friend erythroleukemia metastases after interferon alpha/beta treatment in mice.

1991 • 38 citations

Cure of Mice with Established Metastatic Friend Leukemia Cell Tumors by a Combined Therapy with Tumor Cells Expressing Both Interferon-α1 and Herpes Simplex Thymidine Kinase Followed by Ganciclovir

1996 • 35 citations

Interferon-alpha gene therapy in combination with CD80 transduction reduces tumorigenicity and growth of established tumor in poorly immunogenic tumor models

1999 • 32 citations

Recombinant interferon alpha can induce rearrangement of T-cell antigen receptor alpha-chain genes and maturation to cytotoxicity in T-lymphocyte clones in vitro.

1986 • 32 citations

Type I consensus interferon (CIFN) gene transfer into human melanoma cells up-regulates p53 and enhances cisplatin-induced apoptosis: implications for new therapeutic strategies with IFN-alpha

2000 • 28 citations

Anti‐tumor effects of interferon in mice injected with interferon‐sensitive and interferon‐resistant friend leukemia cells. IV. Definition of optimal treatment regimens

1986 • 28 citations

Successful immunotherapy of the highly metastatic murine ESb lymphoma with sensitized CD8⁺ T cells and IFN‐α/β

1994 • 26 citations

The prognostic significance of immune changes in patients with renal cancer, melanoma and colorectal cancer, treated with interferon α2b

1996 • 26 citations

Interferon β transduction of peripheral blood lymphocytes from HIV-infected donors increases Th1-type cytokine production and improves the proliferative response to recall antigens

1997 • 26 citations

Antitumor activity of recombinant adenoviral vectors expressing murine IFN-α in mice injected with metastatic IFN-resistant tumor cells

2001 • 25 citations

INJECTION OF IRRADIATED B16 MELANOMA GENETICALLY-MODIFIED TO SECRETE IFN-ALPHA CAUSES REGRESSION OF AN ESTABLISHED TUMOR

1995 • 22 citations

Local and systemic antitumor response after combined therapy of mouse metastatic tumors with tumor cells expressing IFN-α and HSVtk: perspectives for the generation of cancer vaccines

1997 • 22 citations

Host CD4+ T lymphocytes are required for the synergistic action of interferon-alpha/beta and adoptively transferred immune cells in the inhibition of visceral ESb metastases.

1995 • 21 citations

In Vivo and In Vitro Glioma Cell Killing Induced by An Adenovirus Expressing Both Cytosine Deaminase and Thymidine Kinase and Its Association with Interferon-α

1999 • 20 citations

Anti‐tumor effects of interferon in mice injected with interferonsensitive and interferon‐resistant friend leukemia cells. VI. Adjuvant therapy after surgery in the inhibition of liver and spleen metastases

1987 • 19 citations

Parameters of interferon action: II. Immunological effects of recombinant leukocyte interferon (IFN-alpha 2) in phase I-II trials.

1983 • 19 citations

The prognostic significance of immune changes in patients with renal cell carcinoma treated with interferon alfa-2b.

1992 • 19 citations

Sensitized T lymphocytes render DBA/2 beige mice responsive to IFN α/β therapy of friend erythroleukemia visceral metastases

1993 • 19 citations

Role of Interferon-α and Clonally Expanded T Cells in the Immunotherapy of Chronic Myelogenous Leukemia

2000 • 15 citations

Treatment of leukemia with fibroblast-mediated interferon-alpha gene therapy alone or in combination with Doxorubicin

1996 • 14 citations

Treatment of human hepatocellular carcinoma by fibroblast-mediated human interferon ? gene therapy in combination with adoptive chemoimmunotherapy

1995 • 14 citations

Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.

1999 • 12 citations

Local and systemic response of mice to interferon-alpha 1-transfected Friend leukemia cells.

1995 • 11 citations

Comparative study on the effects of recombinant alpha-2 interferon on immune function in patients with disseminated melanoma.

1986 • 10 citations

Inhibition of lung colonisation of a mouse mammary carcinoma by therapeutic vaccination with interferon-alpha gene-transduced tumor cells.

1998 • 10 citations

The Effect of Interferon on Experimental Tumor Metastases

1989 • 7 citations

Murine interferon-α1 gene-transduced ESb tumor cells are rejected by host-mediated mechanisms despite resistance of the parental tumor to interferon-α/β therapy

1999 • 7 citations