Autologous Human Monocyte-Derived Dendritic Cells Genetically Modified to Express Melanoma Antigens Elicit Primary Cytotoxic T Cell Responses In Vitro: Enhancement by Cotransfection of Genes Encoding the Th1-Biasing Cytokines IL-12 and IFN-α

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

1995 • 1,828 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

Human tumor antigens recognized by T lymphocytes.

1996 • 860 citations

DNA–based immunization by in vivo transfection of dendritic cells

1996 • 849 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

1994 • 771 citations

Gene vaccination with naked plasmid DNA: mechanism of CTL priming.

1996 • 494 citations

Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines

1995 • 486 citations

Role of interferons and other cytokines in the regulation of the immune response

1995 • 462 citations

Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha.

1995 • 350 citations

In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen.

1997 • 286 citations

Generation of MHC class I‐restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells: antigen presentation by non‐muscle cells

1996 • 264 citations

Dendritic cells as initiators of tumor immune responses: a possible strategy for tumor immunotherapy?

1995 • 264 citations

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.

1996 • 259 citations

Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids.

1997 • 257 citations

Exposing the immunology of naked DNA vaccines

1995 • 254 citations

DNA immunization induces protective immunity against B–cell lymphoma

1996 • 252 citations

Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.

1996 • 245 citations

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

1989 • 241 citations

Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen.

1995 • 222 citations

Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL.

1997 • 215 citations

Antigen-specific tumor vaccines. Development and characterization of recombinant adenoviruses encoding MART1 or gp100 for cancer therapy.

1996 • 161 citations

Intracellular sorting and targeting of melanosomal membrane proteins: identification of signals for sorting of the human brown locus protein, gp75.

1995 • 159 citations

CD4+ blood dendritic cells are potent producers of IFN-alpha in response to in vitro HIV-1 infection.

1994 • 152 citations

DNA vaccines

1996 • 148 citations

Enhancement of cell-mediated immunity against HIV-1 induced by coinnoculation of plasmid-encoded HIV-1 antigen with plasmid expressing IL-12.

1997 • 147 citations

Therapeutic antitumor response after immunization with a recombinant adenovirus encoding a model tumor-associated antigen.

1996 • 138 citations

Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells

1997 • 135 citations

Construction and Characterization of Retroviral Vectors Expressing Biologically Active Human Interleukin-12

1994 • 131 citations

Novel vaccine approaches.

1996 • 125 citations

The Cell Surface Phenotype of Human Natural Interferon‐α Producing Cells as Determined by Flow Cytometry

1996 • 116 citations

Dendritic cells generated from peripheral blood transfected with human tyrosinase induce specific T cell activation

1995 • 106 citations

Shared epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100.

1996 • 106 citations

Isolation of tyrosinase-specific CD8+ and CD4+ T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus.

1996 • 94 citations

The new vaccines: building viruses that elicit antitumor immunity

1996 • 72 citations

Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition

1997 • 66 citations

Induction of a cytolytic T-cell response in mice with a recombinant adenovirus coding for tumor antigen P815A

1996 • 62 citations