Chronic Myelogenous Leukemia: Biology and Therapy

Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia [see comments]

1995 • 2,026 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients

1990 • 1,544 citations

Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation.

1997 • 1,290 citations

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

1984 • 989 citations

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

1984 • 919 citations

Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage

1977 • 888 citations

Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1988 • 887 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype [editorial; comment]

1996 • 739 citations

The Tyrosine Kinase Inhibitor CGP57148B Selectively Inhibits the Growth of BCR-ABL–Positive Cells

1997 • 646 citations

Interferon Alfa-2a as Compared with Conventional Chemotherapy for the Treatment of Chronic Myeloid Leukemia

1994 • 592 citations

Bone Marrow Transplants from Unrelated Donors for Patients with Chronic Myeloid Leukemia

1998 • 587 citations

Marrow Transplantation for the Treatment of Chronic Myelogenous Leukemia

1986 • 566 citations

Interferon Alfa-2b Combined with Cytarabine versus Interferon Alone in Chronic Myelogenous Leukemia

1997 • 565 citations

Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML

1994 • 502 citations

Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals

1995 • 481 citations

Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia. The German CML Study Group [see comments]

1994 • 467 citations

The Presence of Typical and Atypical BCR-ABL Fusion Genes in Leukocytes of Normal Individuals: Biologic Significance and Implications for the Assessment of Minimal Residual Disease

1998 • 457 citations

Chronic myelogenous leukemia: a concise update

1993 • 453 citations

Prolonged Survival in Chronic Myelogenous Leukemia after Cytogenetic Response to Interferon-α Therapy

1995 • 446 citations

BONE MARROW TRANSPLANTS FROM UNRELATED DONORS FOR PATIENTS WITH CHRONIC MYELOID LEUKEMIA

1998 • 429 citations

UK Medical Research Council randomised, multicentre trial of interferon-αn1 for chronic myeloid leukaemia: improved survival irrespective of cytogenetic response

1995 • 409 citations

Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction) [see comments]

1996 • 390 citations

In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor

1999 • 388 citations

Marrow transplantation for chronic myeloid leukemia: a randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide

1994 • 373 citations

Clinical investigation of human alpha interferon in chronic myelogenous leukemia

1987 • 332 citations

Use of Leukemic Dendritic Cells for the Generation of Antileukemic Cellular Cytotoxicity Against Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia

1997 • 309 citations

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

1989 • 300 citations

Chronic myelogenous leukemia in blast crisis

1987 • 283 citations

Interferon Alfa Versus Chemotherapy for Chronic Myeloid Leukemia: A Meta-analysis of Seven Randomized Trials

1997 • 282 citations

Characteristics of accelerated disease in chronic myelogenous leukemia

1988 • 280 citations

A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia

1987 • 278 citations

Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16‐year period

1997 • 254 citations

Cytotoxic T Lymphocytes Specific for a Nonpolymorphic Proteinase 3 Peptide Preferentially Inhibit Chronic Myeloid Leukemia Colony-Forming Units

1997 • 245 citations

MYLERAN IN CHRONIC MYELOID LEUKÆMIA RESULTS OF TREATMENT

1953 • 232 citations

In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides.

1992 • 223 citations

Staging and prognosis in chronic myelogenous leukemia.

1988 • 221 citations

Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group

1993 • 209 citations

Proposal for a simple synthesis prognostic staging system in chronic myelogenous leukemia

1990 • 209 citations

Differentiation patterns in the blastic phase of chronic myeloid leukemia

1983 • 199 citations

Unrelated donor marrow transplantation therapy for chronic myelogenous leukemia: initial experience of the National Marrow Donor Program

1993 • 193 citations

Treatment of chronic myelogenous leukemia: current status and investigational options [see comments]

1996 • 192 citations

A randomized trial comparing interferon-alpha with busulfan for newly diagnosed chronic myelogenous leukemia in chronic phase

1995 • 191 citations

Highly Sensitive Fluorescence In Situ Hybridization Method to Detect Double BCR/ABL Fusion and Monitor Response to Therapy in Chronic Myeloid Leukemia

1998 • 189 citations

The Cytogenetic Scenario of Chronic Myeloid Leukemia

1993 • 188 citations

Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148).

1998 • 185 citations

Interferon alpha-2b as therapy for Ph'-positive chronic myelogenous leukemia: a study of 82 patients treated with intermittent or daily administration

1988 • 184 citations

Homoharringtonine therapy induces responses in patients with chronic myelogenous leukemia in late chronic phase

1995 • 182 citations

Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival: Cancer and Leukemia Group B study 8583 [see comments]

1993 • 170 citations

Long-term results after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase: a report from the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation

1997 • 163 citations

Choice of pretransplant treatment and timing of transplants for chronic myelogenous leukemia in chronic phase [see comments]

1993 • 162 citations

Second HLA-identical sibling transplants for leukemia recurrence.

1992 • 158 citations

Unrelated donor marrow transplantation therapy for chronic myelogenous leukemia: initial experience of the National Marrow Donor Program

1993 • 155 citations

DNA methylation changes in hematologic malignancies: biologic and clinical implications.

1997 • 155 citations

Bone marrow transplantation for chronic myeloid leukemia: long-term results. Chronic Leukemia Working Party of the European Group for Bone Marrow Transplantation.

1993 • 149 citations

P190BCR-ABL chronic myeloid leukaemia: the missing link with chronic myelomonocytic leukaemia?

1994 • 147 citations

Treatment of Philadelphia Chromosome-Positive Early Chronic Phase Chronic Myelogenous Leukemia With Daily Doses of Interferon Alpha and Low-Dose Cytarabine

1999 • 144 citations

Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia

1997 • 140 citations

Choice of pretransplant treatment and timing of transplants for chronic myelogenous leukemia in chronic phase [see comments]

1993 • 135 citations

Hydroxyurea dermopathy: A unique lichenoid eruption complicating long-term therapy with hydroxyurea

1997 • 134 citations

Prolonged administration of interferon-alpha in patients with chronic- phase Philadelphia chromosome-positive chronic myelogenous leukemia before allogeneic bone marrow transplantation may adversely affect transplant outcome

1995 • 124 citations

Hydroxyurea therapy in chronic myelogenous leukemia

1972 • 120 citations

Cancer Incidence and Survival in Patients 65 Years of Age and Older

1986 • 118 citations

Allogeneic bone marrow transplantation for CML: a report from the International Bone Marrow Transplant Registry.

1996 • 117 citations

Treatment of advanced stages of Philadelphia chromosome-positive chronic myelogenous leukemia with interferon-alpha and low-dose cytarabine.

1992 • 117 citations

Chronic myelogenous leukemia in the lymphoid blastic phase: characteristics, treatment response, and prognosis

1993 • 115 citations

Intensive combination chemotherapy (ROAP 10) and splenectomy in the management of chronic myelogenous leukemia.

1985 • 111 citations

Association Between Pretransplant Interferon-α and Outcome After Unrelated Donor Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1998 • 106 citations

Sequential Homoharringtonine and Interferon- in the Treatment of Early Chronic Phase Chronic Myelogenous Leukemia

1999 • 98 citations

Persistence of dormant leukemic progenitors during interferon-induced remission in chronic myelogenous leukemia. Analysis by polymerase chain reaction of individual colonies.

1994 • 96 citations

Outcome for patients who relapse after allogeneic bone marrow transplantation for chronic myeloid leukemia. Chronic Leukemia Working Party. European Bone Marrow Transplantation Group

1993 • 96 citations

Treatment of chronic myeloid leukemia by marrow transplantation [editorial; comment] [see comments]

1993 • 95 citations

Long-Term Follow-Up of the Italian Trial of Interferon- Versus Conventional Chemotherapy in Chronic Myeloid Leukemia

1998 • 95 citations

Busulfan versus hydroxyurea in long-term therapy of chronic myelogenous leukemia

1982 • 95 citations

Generation of dendritic cells expressing bcr-abl from CD34-positive chronic myeloid leukemia precursor cells

1997 • 93 citations

Outcome for patients who relapse after allogeneic bone marrow transplantation for chronic myeloid leukemia. Chronic Leukemia Working Party. European Bone Marrow Transplantation Group

1993 • 88 citations

Effect of prior interferon alfa therapy on the outcome of allogeneic bone marrow transplantation for chronic myelogenous leukemia.

1993 • 87 citations

Hypermetaphase fluorescence in situ hybridization for quantitative monitoring of Philadelphia chromosome-positive cells in patients with chronic myelogenous leukemia during treatment

1995 • 87 citations

Sequential Homoharringtonine and Interferon- in the Treatment of Early Chronic Phase Chronic Myelogenous Leukemia

1999 • 84 citations

Use of alpha interferon for the treatment of relapse of chronic myelogenous leukemia in chronic phase after allogeneic bone marrow transplantation

1992 • 82 citations

Variable numbers of BCR‐ABL transcripts persist in CML patients who achieve complete cytogenetic remission with interferon‐α

1995 • 79 citations

Population‐Based Age‐ and Sex‐Specific Incidence Rates in the 4 Main Types of Leukaemia

1982 • 74 citations

Leg ulcers associated with long-term hydroxyurea therapy

1998 • 73 citations

European results of matched unrelated donor bone marrow transplantation for chronic myeloid leukemia. Impact of HLA class II matching

1997 • 72 citations

CLINICAL COURSE AND THERAPY OF CHRONIC MYELOGENOUS LEUKEMIA WITH INTERFERON-ALPHA AND CHEMOTHERAPY

1998 • 70 citations

BCR-ABL Antisense Oligodeoxynucleotide In Vitro Purging and Autologous Bone Marrow Transplantation for Patients With Chronic Myelogenous Leukemia in Advanced Phase

1998 • 69 citations

Conversion of interferon-induced, long-term cytogenetic remissions in chronic myelogenous leukemia to polymerase chain reaction negativity.

1998 • 65 citations

Bone marrow transplantation for chronic myeloid leukaemia: the effects of differing criteria for defining chronic phase on probabilities of survival and relapse

1997 • 62 citations

Fluorescence in situ hybridization (FISH) on peripheral blood smears for monitoring Philadelphia chromosome-positive chronic myeloid leukemia (CML) during interferon treatment: A new strategy for remission assessment

1998 • 61 citations

Marrow transplantation for CML: the Seattle experience.

1996 • 59 citations

Response at Three Months Is a Good Predictive Factor for Newly Diagnosed Chronic Myeloid Leukemia Patients Treated by Recombinant Interferon-

1998 • 59 citations

Autologous stem cell transplantation in chronic myelogenous leukemia: a retrospective analysis of the European Group for Bone Marrow Transplantation. Chronic Leukemia Working Party of the EBMT.

1994 • 58 citations

Intensive chemotherapy induction followed by interferon-alpha maintenance in patients with Philadelphia chromosome-positive chronic myelogenous leukemia

1991 • 57 citations

Combined Interferon Alfa-2a and Cytosine Arabinoside as First-Line Treatment for Chronic Myeloid Leukemia

1993 • 56 citations

Preferential inhibition by cytarabine of CFU-GM from patients with chronic granulocytic leukemia

1987 • 55 citations

Collection of peripheral-blood diploid cells from chronic myelogenous leukemia patients early in the recovery phase from myelosuppression induced by intensive-dose chemotherapy.

1995 • 53 citations

Response at Three Months Is a Good Predictive Factor for Newly Diagnosed Chronic Myeloid Leukemia Patients Treated by Recombinant Interferon-

1998 • 51 citations

Detection of BCR-ABL proteins in blood cells of benign phase chronic myelogenous leukemia patients.

1991 • 50 citations

p53 loss and point mutations are associated with suppression of apoptosis and progression of CML into myeloid blastic crisis

1997 • 48 citations

New insights in biology and current therapeutic options for patients with chronic myelogenous leukemia.

1997 • 47 citations

Searching for hematopoietic stem cells. II. The heterogeneity of Thy-1.1(lo)Lin(-/lo)Sca-1+ mouse hematopoietic stem cells separated by counterflow centrifugal elutriation.

1996 • 47 citations

9 Allografting for chronic myeloid leukaemia

1997 • 47 citations

Mobilization of Cytogenetically ‘Normal’ Blood Progenitors Cells by Intensive Conventional Chemotherapy for Chronic Myeloid and Acute Lymphoblastic Leukemia

1993 • 42 citations

Unrelated-donor bone marrow transplantation for Philadelphia chromosome-positive chronic myelogenous leukemia in children.

1993 • 42 citations

Genes, Chromosomes and Cancer

2006 • 41 citations

Percentage of Philadelphia chromosome (Ph)-negative and Ph-positive cells found after autologous transplantation for chronic myelogenous leukemia depends on percentage of diploid cells induced by conventional- dose chemotherapy before collection of autologous cells

1995 • 41 citations

Chronic myeloid leukemia as an immunological target

1997 • 40 citations

Decitabine studies in chronic and acute myelogenous leukemia.

1997 • 40 citations

Fluorescence in situ hybridization for the detection and monitoring of the Ph-positive clone in chronic myelogenous leukemia: comparison with metaphase banding analysis

1998 • 39 citations

REPORT OF CASES TREATED WITH ROENTGEN RAYS.

1902 • 39 citations

Results of a prospective randomized trial of early splenectomy in chronic myeloid leukemia. The italian cooperative study group on chronic myeloid leukemia

1984 • 38 citations

Predicting complete cytogenetic response in chronic myelogenous leukemia patients treated with recombinant interferon alpha [letter; comment]

1994 • 37 citations

Molecular Monitoring of Residual Disease in Chronic Myelogenous Leukemia Patients After Therapy

1998 • 36 citations

Effect of interferon-alpha therapy on bone marrow fibrosis in chronic myelogenous leukemia

1998 • 33 citations

Interferon-alpha-2C and LD ara-C for the treatment of patients with CML: Results of the austrian multicenter phase II study

1997 • 32 citations

Absence of influence of prior treatment with interferon on the outcome of allogeneic bone marrow transplantation for chronic myeloid leukemia

1998 • 32 citations

The impact of T-cell depletion on the effects of HLA DR beta 1 and DQ beta allele matching in HLA serologically identical unrelated donor bone marrow transplantation.

1997 • 30 citations

A two-colorBCR–ABL probe that greatly reduces the false positive and false negative rates for fluorescence in situ hybridization in chronic myeloid leukemia

1998 • 28 citations

PH Positive Acute Lymphoblastic Leukemia in Adults: Molecular and Clinical Studies

1995 • 27 citations

2′,5′-Oligoadenylate-Antisense Chimeras Cause RNase L to Selectively Degrade bcr/abl mRNA in Chronic Myelogenous Leukemia Cells

1998 • 26 citations

Multiple squamous cell carcinomas of the skin during long-term treatment with hydroxyurea.

1998 • 25 citations

The Adverse Influence of Pretransplant Interferon- (IFN-) on Transplant Outcome After Marrow Transplantation for Chronic Phase Chronic Myelogenous Leukemia Increases With the Duration of IFN- Exposure

1999 • 24 citations

Molecular Defects Associated with the Acute Phase CML

1993 • 23 citations

Long-term follow-up results of alpha-interferon-based regimens in patients with late chronic phase chronic myelogenous leukemia

1997 • 18 citations

Evolution of bone marrow fibrosis and stromal antigenic expression in chronic myeloid leukemia on alpha interferon and Ara-C therapy.

1996 • 18 citations

Splenectomy in the accelerated or blastic phase of chronic myelogenous leukemia: A single-institution, 25-year experience

1997 • 17 citations

Progress with interferon in CML--results of the MRC UK CML III study.

1996 • 16 citations

Intensive treatment in order to minimize the Ph-positive clone in CML. Danish-Swedish CML Group.

1996 • 14 citations

Biphenotypic Blast Crisis of Chronic Myelogenous Leukemia: Abnormalities of p53 and Retinoblastoma Genes

1997 • 13 citations

P53 Gene Mutations in Chronic Myelogenous Leukemia Medullary and Extramedullary Blast Crisis

1996 • 9 citations

Prior treatment with a-interferon does not adversely affect the outcome of allogeneic BMT in chronic phase chronic myeloid leukemia

1998 • 5 citations

Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy

1998 • 1 citations

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