Mutations to nonsense codons in human genetic disease: implications for gene therapy by nonsense suppressor tRNAs

TRANSCRIPTION BY RNA POLYMERASE III

1988 • 704 citations

Eukaryotic start and stop translation sites

1991 • 602 citations

The Skipping of Constitutive Exons in Vivo Induced by Nonsense Mutations

1993 • 440 citations

Human gene mutation

1993 • 316 citations

Effects of surrounding sequence on the suppression of nonsense codons

1983 • 291 citations

Recurrent mutations in haemophilia A give evidence for CpG mutation hotspots

1986 • 277 citations

Nonrandom utilization of codon pairs in Escherichia coli.

1989 • 264 citations

The vertebrate genome: isochores and evolution.

1993 • 200 citations

Sequence analysis suggests that tetra-nucleotides signal the termination of protein synthesis in eukaryotes

1990 • 189 citations

Translational Efficiency of Transfer RNA's: Uses of an Extended Anticodon

1982 • 185 citations

Construction of Escherichia coli amber suppressor tRNA genes

1990 • 155 citations

Construction of a functional human suppressor tRNA gene: an approach to gene therapy for β-thalassaemia

1982 • 154 citations

Construction of Escherichia coli amber suppressor tRNA genes

1990 • 141 citations

The second to last amino acid in the nascent peptide as a codon context determinant.

1994 • 128 citations

The signal for translational readthrough of a UGA codon in Sindbis virus RNA involves a single cytidine residue immediately downstream of the termination codon

1993 • 125 citations

Human Gene Mutations Affecting RNA Processing and Translation

1993 • 123 citations

The signal for the termination of protein synthesis in procaryotes

1990 • 122 citations

An analysis of codon usage in mammals: Selection or mutation bias?

1991 • 114 citations

The translational termination signal database

1993 • 74 citations

Usage of the three termination codons: Compilation and analysis of the known eukaryotic and prokaryotic translation termination sequences

1981 • 72 citations

Selective differences among translation termination codons

1988 • 66 citations

Introduction of UAG, UAA, and UGA Nonsense Mutations at a Specific Site in the Escherichia coli Chloramphenicol Acetyltransferase Gene: Use in Measurement of Amber, Ochre, and Opal Suppression in Mammalian Cells

1986 • 61 citations

Defined set of cloned termination suppressors: in vivo activity of isogenetic UAG, UAA, and UGA suppressor tRNAs

1984 • 59 citations

The 3′ Codon Context Effect on UAG Suppressor tRNA is Different in Escherichia coli and Human Cells

1993 • 37 citations

tRNA Discrimination in Aminoacylation

2014 • 35 citations

Usage of the three tennination codons in a single eukaryotic cell, the Xenopus laevis oocyte

1981 • 29 citations

Termination of translation in bacteria may be modulated via specific interaction between peptide chain release factor 2 and the last peptidyl-tRNA^Ser/Phe

1993 • 28 citations

On the relationship between preferred termination codon contexts and nonsense suppression in human cells

1994 • 21 citations

Codon context effects on nonsense suppression in human cells

1993 • 20 citations

Modulation of the Phenotypic Expression of a Human Serine tRNA Gene by 5′-Flanking Sequences

1988 • 10 citations