Review

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A

1995 • 976 citations

Calcium-activated neutral protease (calpain) system: structure, function, and regulation.

1991 • 841 citations

Calpain: new perspectives in molecular diversity and physiological‐pathological involvement

1994 • 673 citations

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

1993 • 575 citations

Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain

1994 • 314 citations

Calpain inhibition: an overview of its therapeutic potential

1994 • 280 citations

Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration.

1994 • 219 citations

Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.

1994 • 183 citations

New era of calpain research

1994 • 183 citations

Ca(2+)-activated neutral protease is active in the erythrocyte membrane in its nonautolyzed 80-kDa form.

1994 • 98 citations

Ezrin-calpain I interactions in gastric parietal cells

1993 • 96 citations

Calcium activated neutral protease. - Structure-function relationship and functional implications.

1990 • 96 citations

Calpain Dissociates into Subunits in the Presence Ions

1995 • 95 citations

Ca2+-dependent proteinases (calpains) and muscle cell differentiation

1994 • 91 citations

Molecular cloning and analysis of small optic lobes, a structural brain gene of Drosophila melanogaster.

1991 • 88 citations

Characterization of cDNA clones encoding a novel calcium-activated neutral proteinase from Schistosoma mansoni

1991 • 88 citations

Calpain Expression in Lymphoid Cells

1995 • 87 citations

Differential Proteolysis of the Full‐Length Form of the L‐Type Calcium Channel α1 Subunit by Calpain

1994 • 78 citations

Active recombinant rat calpain II. Bacterially produced large and small subunits associate both in vivo and in vitro.

1994 • 72 citations

Distinct kinetics of subunit autolysis in mammalian m‐calpain activation

1994 • 67 citations

Endogenous Cleavage of Phospholipase C-β3 by Agonist-induced Activation of Calpain in Human Platelets

1995 • 64 citations

Calpain localization changes in coordination with actin-related cytoskeletal changes during early embryonic development of Drosophila.

1994 • 63 citations

PEST Sequences Do Not Influence Substrate Susceptibility to Calpain Proteolysis

1995 • 61 citations

CalpA, a Drosophila Calpain Homolog Specifically Expressed in a Small Set of Nerve, Midgut, and Blood Cells

1995 • 59 citations

Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera.

1995 • 55 citations

Unphosphorylated and tyrosine‐phosphorylated forms of a focal adhesion protein, paxillin, are substrates for calpain II in vitro: Implications for the possible involvement of calpain II in mitosis‐specific degradation of paxillin

1994 • 49 citations

Degradation of protein kinase Cα and its free catalytic subunit, protein kinase M, in intact human neuroblastoma cells and under cell‐free conditions

1994 • 47 citations

m-Calpain requires DNA for activity on nuclear proteins at low calcium concentrations.

1993 • 47 citations

Calpain inhibitors block Ca²⁺‐induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons

1994 • 46 citations

Calpain-mediated regulation of AMPA receptors in adult rat brain

1994 • 44 citations

Purification and characterization of a calcium-activated thiol protease from Drosophila melanogaster

1992 • 41 citations

Calpain-Calpastatin Interactions in Epidermoid Carcinoma KB Cells1

1994 • 38 citations

The calpain cleavage sites in the epidermal growth factor receptor kinase domain

1994 • 37 citations

Selective Nuclear Transport of μ-Calpain

1994 • 32 citations

Inhibition of Growth of Human TE2 and C-33A Cells by the Cell-Permeant Calpain Inhibitor Benzyloxycarbonyl-Leu-Leu-Tyr Diazomethyl Ketone

1994 • 29 citations

Calcium-Dependent Proteinase Activity in Root Cultures of Arabidopsis

1994 • 28 citations

Isolation and identification of a μ‐calpain‐protein kinase Cα complex in skeletal muscle

1995 • 27 citations

Protein kinase C V₃ domain mutants with differential sensitivities to m‐calpain are not resistant to phorbol‐ester‐induced down‐regulation

1994 • 27 citations

Brain G-protein proteolysis by calpain: enhancement by lithium

1994 • 27 citations

The calpain—calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells

1994 • 25 citations

Transcriptional activation of the gene for the large subunit of human m‐calpain by 12‐o‐tetradecanoyl‐phorbol‐13‐acetate

1992 • 21 citations

Calpain-induced down-regulation of protein kinase C inhibits dense-granule secretion in human platelets. Inhibition of platelet aggregation or calpain activity preserves protein kinase C and restores full secretion

1994 • 18 citations

Calcium-dependent inactivation of RNA polymerase III transcription.

1994 • 14 citations

Involvement of protein kinase-C, calpains, and calpastatin in prostaglandin F2 alpha-induced oxytocin secretion from the bovine corpus luteum

1994 • 8 citations