Identification of a Critical Sp1 Site within the Endoglin Promoter and Its Involvement in the Transforming Growth Factor-β Stimulation

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

1994 • 1,452 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Defective Angiogenesis in Mice Lacking Endoglin

1999 • 851 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily

1999 • 562 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

Transcription Factor Sp1 Is Essential for Early Embryonic Development but Dispensable for Cell Growth and Differentiation

1997 • 524 citations

Smads as transcriptional co-modulators

2000 • 522 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

A murine model of hereditary hemorrhagic telangiectasia

1999 • 472 citations

Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

2000 • 433 citations

OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways

2000 • 428 citations

Characterization of the Promoter Region of the Human Transforming Growth Factor-β1 Gene

1989 • 400 citations

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-β

2000 • 392 citations

Role of Smad Proteins and Transcription Factor Sp1 in p21Waf1/Cip1 Regulation by Transforming Growth Factor-β

2000 • 389 citations

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15

1997 • 378 citations

Signaling inputs converge on nuclear effectors in TGF-β signaling

2000 • 359 citations

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

1998 • 348 citations

Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1.

1993 • 310 citations

Endoglin modulates cellular responses to TGF-beta 1.

1996 • 306 citations

Transcriptional regulation by the Sp family proteins

1997 • 287 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Cell Cycle-Regulated Association of E2F1 and Sp1 Is Related to Their Functional Interaction

1996 • 268 citations

Transcriptional Activation of Transforming Growth Factor β1 and Its Receptors by the Kruppel-like Factor Zf9/Core Promoter-binding Protein and Sp1

1998 • 250 citations

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

1995 • 249 citations

Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4

1999 • 249 citations

CD105 antagonizes the inhibitory signaling of transforming growth factor βl on human vascular endothelial cells

2000 • 232 citations

Role of Endoglin in Cellular Responses to Transforming Growth Factor-β

1998 • 223 citations

Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression.

1995 • 212 citations

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

1998 • 195 citations

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.

1994 • 193 citations

c-Jun Transactivates the Promoter of the Human p21 Gene by Acting as a Superactivator of the Ubiquitous Transcription Factor Sp1

1999 • 191 citations

Characterization of a Bone Morphogenetic Protein-responsive Smad-binding Element

2000 • 182 citations

Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites.

1992 • 181 citations

Characterization of Endoglin and Identification of Novel Mutations in Hereditary Hemorrhagic Telangiectasia

1997 • 166 citations

Functional Interference of Sp1 and NF-κB through the Same DNA Binding Site

1998 • 160 citations

Efficient TGF-β Induction of the Smad7 Gene Requires Cooperation between AP-1, Sp1, and Smad Proteins on the Mouse Smad7 Promoter

2000 • 155 citations

Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative.

1997 • 154 citations

Regulation of Plasminogen Activator Inhibitor-1 Expression by Transforming Growth Factor-β-induced Physical and Functional Interactions between Smads and Sp1

2000 • 135 citations

Distinct Subdomains of Human TAF_II130 Are Required for Interactions with Glutamine-Rich Transcriptional Activators

1998 • 131 citations

Characterization of the Promoter Region of the Human Transforming Growth Factor-β Type II Receptor Gene

1995 • 116 citations

The Role of FAST-1 and Smads in Transcriptional Regulation by Activin during Early Xenopus Embryogenesis

1999 • 111 citations

Cloning of the Promoter Region of Human Endoglin, the Target Gene for Hereditary Hemorrhagic Telangiectasia Type 1

1998 • 110 citations

Transforming Growth Factor-β Up-regulates the β5Integrin Subunit Expression via Sp1 and Smad Signaling

2000 • 101 citations

Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles

1998 • 98 citations

Distribution of endoglin in early human development reveals high levels on endocardial cushion tissue mesenchyme during valve formation

1998 • 62 citations

Structure, Chromosomal Localization, and Expression Analysis of the Mouse Inhibin/Activin βC(Inhbc) Gene

1996 • 60 citations

Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro

1999 • 59 citations

Drosophila dSmad2 and Atr‐I transmit activin/TGFβ signals

1999 • 42 citations

Structure and Expression of the Promoter for the Human Type II Transforming Growth Factor-β Receptor

1994 • 32 citations

Studying the recruitment of Sp1 to the β-globin promoter with an in vivo method: Protein position identification with nuclease tail (PIN*POINT)

1998 • 26 citations

Production of the transforming growth factor-β binding protein endoglin is regulated during chick heart development

1998 • 23 citations