Microparticles in cardiovascular diseases

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

The Nature and Significance of Platelet Products in Human Plasma

1967 • 1,471 citations

Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells

1997 • 1,321 citations

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

2001 • 1,239 citations

Elevated Levels of Shed Membrane Microparticles With Procoagulant Potential in the Peripheral Circulating Blood of Patients With Acute Coronary Syndromes

2000 • 876 citations

In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant

1999 • 720 citations

Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

1988 • 663 citations

Endothelial Dysfunction in Preeclampsia

1998 • 637 citations

Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation

2001 • 635 citations

TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex

2002 • 624 citations

Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques

1999 • 619 citations

Assembly of the Platelet Prothrombinase Complex Is Linked to Vesiculation of the Platelet Plasma Membrane

1989 • 597 citations

P-selectin induces the expression of tissue factor on monocytes.

1994 • 595 citations

Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: A mechanism for cellular human immunodeficiency virus 1 infection

2000 • 587 citations

Cellular origin and procoagulant properties of microparticles in meningococcal sepsis

2000 • 568 citations

Modulation of monocyte-endothelial cell interactions by platelet microparticles.

1998 • 531 citations

Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease

1997 • 524 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro.

1992 • 519 citations

Circulating Microparticles From Patients With Myocardial Infarction Cause Endothelial Dysfunction

2001 • 491 citations

Apoptotic Membrane Blebbing Is Regulated by Myosin Light Chain Phosphorylation

1998 • 486 citations

Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles.

1997 • 486 citations

Platelet-activating factor: receptors and signal transduction

1993 • 459 citations

Shear-Induced Platelet Activation and Platelet Microparticle Formation at Blood Flow Conditions as in Arteries With a Severe Stenosis

1997 • 440 citations

The Oxidative Modification Hypothesis of Atherosclerosis Does It Hold for Humans?

2001 • 435 citations

Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis".

1996 • 404 citations

Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide.

1994 • 367 citations

High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles

1996 • 366 citations

Endothelial Cell Activation by Leukocyte Microparticles

1998 • 365 citations

Cell-Derived Microparticles Generated in Patients During Cardiopulmonary Bypass Are Highly Procoagulant

1997 • 344 citations

Leukocyte Microparticles Stimulate Endothelial Cell Cytokine Release and Tissue Factor Induction in a JNK1 Signaling Pathway

1999 • 343 citations

Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex.

1990 • 342 citations

Scavenger Receptors, Oxidized LDL, and Atherosclerosis

2001 • 329 citations

High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells

2001 • 295 citations

Oxidized Membrane Vesicles and Blebs From Apoptotic Cells Contain Biologically Active Oxidized Phospholipids That Induce Monocyte-Endothelial Interactions

2002 • 293 citations

Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles

1991 • 277 citations

Platelet-derived microparticles express high affinity receptors for factor VIII.

1991 • 277 citations

The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection.

1997 • 273 citations

Leukocyte-leukocyte interactions mediated by platelet microparticles under flow

2000 • 268 citations

Elevated Levels of Circulating Procoagulant Microparticles in Patients With Paroxysmal Nocturnal Hemoglobinuria and Aplastic Anemia

1999 • 267 citations

Clinical significance of platelet microparticles in autoimmune thrombocytopenias.

1992 • 254 citations

Microparticles from Patients with Multiple Organ Dysfunction Syndrome and Sepsis Support Coagulation through Multiple Mechanisms

2001 • 252 citations

Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias

1993 • 251 citations

Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis.

1992 • 250 citations

The Platelet Cytoskeleton

1993 • 235 citations

Platelet-derived microparticles may influence the development of atherosclerosis in diabetes mellitus

1995 • 223 citations

Ca++-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin

2002 • 221 citations

Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor

1991 • 221 citations

Morphological analysis of microparticle generation in heparin-induced thrombocytopenia

2000 • 199 citations

Platelet Microparticles Bind, Activate and Aggregate Neutrophils In Vitro

1995 • 196 citations

Cell‐derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII–dependent mechanism

2002 • 189 citations

Vitamin C Inhibits Endothelial Cell Apoptosis in Congestive Heart Failure

2001 • 189 citations

Activated Platelets Enhance Microparticle Formation and Platelet-Leukocyte Interaction in Severe Trauma and Sepsis

2001 • 187 citations

Current Perspective on the Role of Apoptosis in Atherothrombotic Disease

2001 • 182 citations

Role of the membrane skeleton in preventing the shedding of procoagulant-rich microvesicles from the platelet plasma membrane.

1990 • 162 citations

A Simple Method of Studying the Generation of Thrombin in Recalcified Plasma: Application in the Investigation of Haemophilia

1953 • 155 citations

Platelet-derived microparticles associate with fibrin during thrombosis

1996 • 150 citations

Microparticle subpopulations are increased in preeclampsia: Possible involvement in vascular dysfunction?

2002 • 148 citations

Phospholipid Composition of Cell-Derived Microparticles Determined by One-Dimensional High-Performance Thin-Layer Chromatography

2002 • 146 citations

Platelet-derived microparticle formation involves glycoprotein IIb-IIIa. Inhibition by RGDS and a Glanzmann's thrombasthenia defect

1993 • 142 citations

Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury

1996 • 139 citations

Novel leukocyte agonists are released by endothelial cells exposed to peroxide.

1992 • 129 citations

Release of Active Tissue Factor by Human Arterial Smooth Muscle Cells

2000 • 124 citations

Enrichment of two glycosyl-phosphatidylinositol-anchored proteins, acetylcholinesterase and decay accelerating factor, in vesicles released from human red blood cells

1989 • 120 citations

The in vivo quantitation and kinetics of monocyte migration into acute inflammatory tissue.

1981 • 117 citations

Endothelium and acute coronary syndromes

1998 • 105 citations

Participation of protein kinases in complement C5b-9-induced shedding of platelet plasma membrane vesicles

1991 • 97 citations

Platelet-Derived Microparticles in Patients with Arteriosclerosis Obliterans

2000 • 87 citations

Plasma tissue factor and tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation

1997 • 86 citations

Characterization of a novel bleeding disorder with isolated prolonged bleeding time and deficiency of platelet microvesicle generation

1997 • 85 citations

The role of protein phosphorylation and cytoskeletal reorganization in microparticle formation from the platelet plasma membrane

1994 • 85 citations

Amyloid beta-protein precursor-rich platelet microparticles in thrombotic disease.

1994 • 81 citations

Release of vesicles enriched in complement receptor 1 from human erythrocytes.

1993 • 73 citations

Correlation between inhibition of cytoskeleton proteolysis and anti-vesiculation effect of calpeptin during A23187-induced activation of human platelets: are vesicles shed by filopod fragmentation?

1994 • 72 citations

Enhanced Coagulation Activation in Preeclampsia: the Role of APC Resistance, Microparticles and Other Plasma Constituents

2002 • 72 citations

Thrombin‐induced adherence of neutrophils to cultured endothelial monolayers: Increased endothelial adhesiveness

1988 • 57 citations

Vascular dysfunction and heart failure: Epiphenomenon or etiologic agent?

2002 • 55 citations

Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion

1995 • 46 citations

Activated Protein C Resistance: Effect of Platelet Activation, Platelet-Derived Microparticles, and Atherogenic Lipoproteins

1999 • 45 citations

Apoptosis in Vascular Disease

1999 • 41 citations

Endothelial dysfunction in arterial hypertension

2000 • 36 citations

Infusion of Phospholipid Vesicles Amplifies the Local Thrombotic Response to TNF and Anti-Protein C into a Consumptive Response

1996 • 36 citations

Annexin V Inhibits Phosphatidylserine-induced Intrauterine Growth Restriction in Mice

1999 • 33 citations

Antiplatelet autoantibody-related microparticles in patients with idiopathic (autoimmune) thrombocytopenic purpura

1991 • 32 citations

Receptor-dependent internalization of platelet-activating factor.

1994 • 24 citations

Association of Localized Ca ²⁺ Gradients With Redistribution of Glycoprotein IIb-IIIa and F-actin in Activated Human Blood Platelets

1996 • 23 citations

Inhibition of endothelium-dependent arterial relaxation by oxidized phosphatidylcholine

2000 • 18 citations

Is apoptosis cause of pre-eclampsia?

2000 • 8 citations

Anticoagulation and the heart.

2001 • 3 citations