High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

1988 • 663 citations

The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.

1991 • 619 citations

Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation.

1986 • 609 citations

Assembly of the Platelet Prothrombinase Complex Is Linked to Vesiculation of the Platelet Plasma Membrane

1989 • 597 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery.

1986 • 457 citations

1-(5-isoquinol inesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase c in rabbit platelets

1984 • 437 citations

Direct detection of activated platelets and platelet-derived microparticles in humans

1990 • 429 citations

Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin

1988 • 365 citations

Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: a flow cytometry study showing a role for free sulfhydryl groups

1993 • 348 citations

A Spatial-Temporal Model of Cell Activation

1988 • 347 citations

von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.

1991 • 280 citations

von Willebrand factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib.

1986 • 270 citations

Characterization of the Unique Mechanism Mediating the Shear-dependent Binding of Soluble von Willebrand Factor to Platelets

1995 • 266 citations

Synthesis of a new cell penetrating calpain inhibitor (calpeptin)

1988 • 254 citations

Clinical significance of platelet microparticles in autoimmune thrombocytopenias.

1992 • 254 citations

Elevated platelet microparticles in transient ischemic attacks, lacunar infarcts, and multiinfarct dementias

1993 • 251 citations

Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets

1991 • 225 citations

Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria

1993 • 220 citations

Shear-induced platelet aggregation

1990 • 211 citations

Transmembrane Calcium Influx Associated with von Willebrand Factor Binding to GP Ib in the Initiation of Shear-Induced Platelet Aggregation

1993 • 171 citations

Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles.

1991 • 168 citations

Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor

1990 • 166 citations

Platelet procoagulant activity and microvesicle formation. Its putative role in hemostasis and thrombosis.

1992 • 166 citations

Mechanisms of Shear-induced Platelet Adhesion and Aggregation

1993 • 164 citations

Role of the membrane skeleton in preventing the shedding of procoagulant-rich microvesicles from the platelet plasma membrane.

1990 • 162 citations

Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin, glycoprotein IIb-IIIa.

1993 • 136 citations

Isolation and chemical characterization of two structurally and functionally distinct forms of botrocetin, the platelet coagglutinin isolated from the venom of Bothrops jararaca

1991 • 117 citations

Demonstration of Platelet-Derived Microvesicles in Blood from Patients with Activated Coagulation and Fibrinolysis Using a Filtration Technique and Western Blotting

1994 • 114 citations

Protein kinase C is activated in platelets subjected to pathological shear stress.

1993 • 99 citations

Epinephrine augments von Willebrand factor-dependent shear-induced platelet aggregation.

1992 • 85 citations

Shear-stress-induced von Willebrand factor binding to platelets causes the activation of tyrosine kinase(s)

1994 • 77 citations

Calpain activity in patients with thrombotic thrombocytopenic purpura is associated with platelet microparticles

1992 • 74 citations

Studies on anti-von Willebrand factor (vWF) monoclonal antibody NMC-4, which inhibits both ristocetin- and botrocetin-induced vWF binding to platelet glycoprotein Ib

1991 • 67 citations

The role of calpain in stimulus-response coupling: evidence that calpain mediates agonist-induced expression of procoagulant activity in platelets

1990 • 66 citations

Effects of EDTA on the membrane glycoproteins IIB-IIIa complex — analysis using flow cytometry

1987 • 60 citations

Differences between platelet and microparticle glycoprotein IIb/IIIa

1992 • 58 citations

Protein Tyrosine Phosphorylation in Human Platelets during Shear Stress-Induced Platelet Aggregation (SIPA) Is Regulated by Glycoprotein (GP) Ib/IX as well as GP IIb/IIIa and Requires Intact Cytoskeleton and Endogenous ADP

1995 • 54 citations

Low shear stress can initiate von Willebrand factor-dependent platelet aggregation in patients with type IIB and platelet-type von Willebrand disease.

1993 • 41 citations

The effect of PGI2 and theophylline on the response of platelets subjected to shear stress

1981 • 39 citations

Platelet activation induced by an antiplatelet autoantibody against CD9 antigen and its inhibition by another autoantibody in immune thrombocytopenic purpura

1993 • 33 citations

Analysis of platelet antigen for anti-platelet antibodies in idiopathic thrombocytopenic purpura using flow cytometry.

1988 • 30 citations

Microparticle generation during in vitro platelet activation by anti-CD9 murine monoclonal antibodies

1991 • 28 citations

Immunolocalization of beta 1 integrins in platelets and platelet- derived microvesicles

1993 • 22 citations

Activation of protein kinase C in platelets by epinephrine and A23187: correlation with fibrinogen binding

1989 • 21 citations

Binding of Human Platelet Glycoprotein lb and Actin to Fragments of Actin-Binding Protein

1992 • 14 citations

Internalization of an Anti-Glycoprotein IIb/IIIa Antibody by HEL Cells

1995 • 9 citations