Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2006 • 2,500 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

T Cell Activation

2009 • 1,898 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

2005 • 1,613 citations

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

2009 • 1,347 citations

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

2008 • 1,304 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma

2008 • 647 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

Interleukin-12: Biological Properties and Clinical Application

2007 • 569 citations

Adoptive cell therapy for the treatment of patients with metastatic melanoma

2009 • 568 citations

Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies.

1997 • 556 citations

Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients

2010 • 435 citations

Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.

1992 • 407 citations

Clinical Trials: IL-12 Deaths: Explanation and a Puzzle

1995 • 333 citations

CD8+ Enriched “Young” Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma

2010 • 289 citations

T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons.

1995 • 283 citations

Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

2010 • 243 citations

High Efficiency TCR Gene Transfer into Primary Human Lymphocytes Affords Avid Recognition of Melanoma Tumor Antigen Glycoprotein 100 and Does Not Alter the Recognition of Autologous Melanoma Antigens

2003 • 231 citations

Transfer of a TCR Gene Derived from a Patient with a Marked Antitumor Response Conveys Highly Active T-Cell Effector Functions

2005 • 229 citations

Immunotherapy of cancer by IL-12-based cytokine combinations

2007 • 215 citations

Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes.

1993 • 214 citations

Defects in the interferon‐γ and interleukin‐12 pathways

2005 • 211 citations

The Toxicology of Interleukin-12: A Review

1999 • 204 citations

IL-12 initiates tumor rejection via lymphoid tissue–inducer cells bearing the natural cytotoxicity receptor NKp46

2010 • 201 citations

Amount of interleukin 12 available at the tumor site is critical for tumor regression.

1996 • 177 citations

A Tumor-selective Biotherapy With Prolonged Impact on Established Metastases Based on Cytokine Gene-engineered MSCs

2008 • 163 citations

Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo

1997 • 146 citations

Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma

2009 • 142 citations

Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12.

1999 • 141 citations

Interleukin 12 Gene Therapy of Cancer by Peritumoral Injection of Transduced Autologous Fibroblasts: Outcome of a Phase I Study

2001 • 134 citations

Anti‐tumor activity of mesenchymal stem cells producing IL‐12 in a mouse melanoma model

2006 • 126 citations

Recognition of Fresh Human Tumor by Human Peripheral Blood Lymphocytes Transduced with a Bicistronic Retroviral Vector Encoding a Murine Anti-p53 TCR

2005 • 124 citations

Improving Transcriptional Termination of Self-inactivating Gamma-retroviral and Lentiviral Vectors

2007 • 121 citations

Interleukin‐12 regulates the proliferation of Th1, but not Th2 or Th0, clones

1994 • 118 citations

Intratumoral injection of IL-12 plasmid DNA – results of a phase I/IB clinical trial

2007 • 102 citations

Recognition of NY-ESO-1+ tumor cells by engineered lymphocytes is enhanced by improved vector design and epigenetic modulation of tumor antigen expression

2008 • 85 citations

A strategy for treatment of Epstein–Barr virus-positive Hodgkin's disease by targeting interleukin 12 to the tumor environment using tumor antigen-specific T cells

2003 • 78 citations

Enrichment of CD8+ Cells From Melanoma Tumor-infiltrating Lymphocyte Cultures Reveals Tumor Reactivity for Use in Adoptive Cell Therapy

2010 • 72 citations

The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12.

1997 • 69 citations

NFAT-controlled expression of GFP permits visualization and isolation of antigen-stimulated primary human T cells

2000 • 55 citations

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

2004 • 47 citations

Interleukin-12: A Recently Discovered Cytokine with Potential for Enhancing Cell-Mediated Immune Responses to Tumors

1993 • 46 citations

Inhibition of TCR-Induced CD8 T Cell Death by IL-12: Regulation of Fas Ligand and Cellular FLIP Expression and Caspase Activation by IL-12

2003 • 44 citations

Murine Models of Cancer Cytokine Gene Therapy Using Interleukin‐12a

1996 • 42 citations

IL-12 PLAYS A SIGNIFICANT ROLE IN THE APOPTOSIS OF HUMAN T CELLS IN THE ABSENCE OF ANTIGENIC STIMULATION

2002 • 20 citations

Clinical use of systemic IL-12 therapy.

2001 • 18 citations