Improving Transcriptional Termination of Self-inactivating Gamma-retroviral and Lentiviral Vectors

LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

2003 • 3,480 citations

A Third-Generation Lentivirus Vector with a Conditional Packaging System

1998 • 3,175 citations

Transcription Start Regions in the Human Genome Are Favored Targets for MLV Integration

2003 • 1,310 citations

Formation of mRNA 3′ Ends in Eukaryotes: Mechanism, Regulation, and Interrelationships with Other Steps in mRNA Synthesis

1999 • 1,016 citations

Mechanism and regulation of mRNA polyadenylation

1997 • 762 citations

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

2006 • 695 citations

Murine Leukemia Induced by Retroviral Gene Marking

2002 • 669 citations

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells.

1986 • 533 citations

Clonal Dominance of Hematopoietic Stem Cells Triggered by Retroviral Gene Marking

2005 • 336 citations

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

2006 • 323 citations

Retroviral insertional mutagenesis: past, present and future

2005 • 272 citations

Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase

2004 • 245 citations

Efficiency of Utilization of the Simian Virus 40 Late Polyadenylation Site: Effects of Upstream Sequences

1989 • 205 citations

Context Dependence of Different Modules for Posttranscriptional Enhancement of Gene Expression from Retroviral Vectors

2000 • 195 citations

Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine–DNA methyltransferase in hematopoietic cells

2005 • 186 citations

Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro.

1996 • 167 citations

Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses.

1990 • 159 citations

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3′ end formation by two distinct mechanisms

1998 • 156 citations

Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal.

1994 • 146 citations

The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation.

1991 • 136 citations

RNA 3′ Readthrough of Oncoretrovirus and Lentivirus: Implications for Vector Safety and Efficacy

2002 • 128 citations

CPSF recognition of an HIV-1 mRNA 3'-processing enhancer: multiple sequence contacts involved in poly(A) site definition.

1995 • 128 citations

Distinct Domains of AU-Rich Elements Exert Different Functions in mRNA Destabilization and Stabilization by p38 Mitogen-Activated Protein Kinase or HuR

2004 • 125 citations

Polyadenylation: A tail of two complexes

2002 • 107 citations

A dissection of the cauliflower mosaic virus polyadenylation signal.

1991 • 105 citations

Lentiviral vectors pseudotyped with murine ecotropic envelope: Increased biosafety and convenience in preclinical research

2006 • 102 citations

Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways

2006 • 101 citations

Efficiency of utilization of the simian virus 40 late polyadenylation site: effects of upstream sequences.

1989 • 91 citations

Upstream sequence elements enhance poly(A) site efficiency of the C2 complement gene and are phylogenetically conserved.

1995 • 89 citations

Activation of HIV-1 pre-mRNA 3′ processing in vitro requires both an upstream element and TAR.

1992 • 87 citations

Definition of the Upstream Efficiency Element of the Simian Virus 40 Late Polyadenylation Signal by Using In Vitro Analyses

1992 • 81 citations

The prothrombin 3′end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations

2004 • 79 citations

Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector dose

2003 • 65 citations

Regulation of polyadenylation in hepatitis B viruses: stimulation by the upstream activating signal PS1 is orientation-dependent, distance-independent, and additive

1991 • 59 citations

Definition of the upstream efficiency element of the simian virus 40 late polyadenylation signal by using in vitro analyses.

1992 • 43 citations

Upstream sequences and cap proximity in the regulation of polyadenylation in ground squirrel hepatitis virus

1992 • 42 citations

Sequence elements upstream of the 3' cleavage site confer substrate strength to the adenovirus L1 and L3 polyadenylation sites.

1994 • 40 citations

3′ End Processing of the Prothrombin mRNA in Thrombophilia

2006 • 40 citations

R Region Sequences in the Long Terminal Repeat of a Murine Retrovirus Specifically Increase Expression of Unspliced RNAs

1999 • 39 citations

The Retroviruses Human Immunodeficiency Virus Type 1 and Moloney Murine Leukemia Virus Adopt Radically Different Strategies To Regulate Promoter-Proximal Polyadenylation

2001 • 39 citations

Sequences regulating temporal poly(A) site switching in the adenovirus major late transcription unit.

1991 • 33 citations

Improving the Post-Transcriptional Aspects of Lentiviral Vectors

2002 • 26 citations