Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain.

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

1989 • 2,090 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.

1988 • 514 citations

Platelet-derived growth factor: mechanism of action and possible in vivo function.

1990 • 491 citations

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

1986 • 478 citations

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1986 • 418 citations

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

1989 • 413 citations

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

1983 • 352 citations

cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.

1988 • 338 citations

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.

1988 • 317 citations

Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin.

1986 • 270 citations

Autocrine Stimulation of Intracellular PDGF Receptors in v- sis -Transformed Cells

1988 • 267 citations

Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets

1990 • 226 citations

Selective expression of PDGF A and its receptor during early mouse embryogenesis

1990 • 215 citations

Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus

1985 • 205 citations

Human-Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma Virus

1984 • 203 citations

Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.

1988 • 187 citations

Comparison of Biological Properties and Transforming Potential of Human PDGF-A and PDGF-B Chains

1988 • 178 citations

The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein.

1985 • 143 citations

Platelet-Derived Growth Factor A Chain Is Maternally Encoded in Xenopus Embryos

1988 • 141 citations

Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins.

1988 • 139 citations

Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.

1989 • 112 citations

Characterization of the Polypeptide Composition of Human Factor VIII:C and the Nucleotide Sequence and Expression of the Human Kidney cDNA

1985 • 104 citations

Demonstration of an antibody against platelet-derived growth factor

1981 • 97 citations

Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer.

1988 • 96 citations

The alternatively spliced exon of the platelet-derived growth factor A chain encodes a nuclear targeting signal.

1989 • 92 citations

Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules.

1987 • 85 citations

Platelet-Derived Growth Factor

1987 • 85 citations

cDNA Cloning and Expression of a Human Platelet-Derived Growth Factor (PDGF) Receptor Specific for B-Chain-Containing PDGF Molecules

1988 • 76 citations

Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects.

1988 • 71 citations

Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B

1990 • 60 citations

Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.

1989 • 58 citations

Localization of platelet-derived growth factor (PDGF) in CHO cells transfected with PDGF A- or B-chain cDNA: Retention of PDGF-BB in the endoplasmic reticulum and Golgi complex

1990 • 57 citations

Platelet-Derived Growth Factor

1991 • 44 citations

Intracellular turnover, novel secretion, and mitogenically active intracellular forms of v-sis gene product in simian sarcoma virus-transformed cells. Implications for intracellular loop autocrine transformation.

1990 • 39 citations

Structural Characterization of the Human Platelet-Derived Growth Factor A-Chain cDNA and Gene: Alternative Exon Usage Predicts Two Different Precursor Proteins

1988 • 27 citations

The Alternatively Spliced Exon of the Platelet-Derived Growth Factor A Chain Encodes a Nuclear Targeting Signal

1989 • 27 citations

Expression of Recombinant Platelet-Derived Growth Factor A-and B-Chain Homodimers in Rat-1 Cells and Human Fibroblasts Reveals Differences in Protein Processing and Autocrine Effects

1988 • 22 citations

Identification of a Signal for Nuclear Targeting in Platelet-Derived-Growth-Factor-Related Molecules

1987 • 19 citations

Alternative Splicing of the Platelet-Derived Growth Factor A-Chain Transcript Occurs in Normal as Well as Tumor Cells and Is Conserved among Mammalian Species

1989 • 15 citations