Molecular Biology and Transgenetics of Prion Diseases

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

1943 • 3,852 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1984 • 1,633 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

CELL-SURFACE ANCHORING OF PROTEINS VIA GLYCOSYL-PHOSPHATIDYLINOSITOL STRUCTURES

1988 • 1,284 citations

Identification of a Protein That Purifies with the Scrapie Prion

1982 • 1,260 citations

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

1989 • 1,128 citations

Nature of the Scrapie Agent: Self-replication and Scrapie

1967 • 1,128 citations

Scrapie prion protein contains a phosphatidylinositol glycolipid

1987 • 1,104 citations

A novel progressive spongiform encephalopathy in cattle

1987 • 1,062 citations

Scrapie prions aggregate to form amyloid-like birefringent rods

1983 • 1,048 citations

A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine

1987 • 1,021 citations

A protease-resistant protein is a structural component of the Scrapie prion

1983 • 919 citations

Unconventional Viruses and the Origin and Disappearance of Kuru

1977 • 897 citations

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

1990 • 874 citations

Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome

1989 • 834 citations

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

1986 • 829 citations

Experimental Transmission of a Kuru-like Syndrome to Chimpanzees

1966 • 828 citations

Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to the Chimpanzee

1968 • 778 citations

CHRONIC WASTING DISEASE OF CAPTIVE MULE DEER: A SPONGIFORM ENCEPHALOPATHY

1980 • 760 citations

Apolipoprotein B-48 Is the Product of a Messenger RNA with an Organ-Specific In-Frame Stop Codon

1987 • 746 citations

Bovine spongiform encephalopathy: epidemiological studies.

1988 • 721 citations

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

1989 • 696 citations

Does the Agent of Scrapie Replicate without Nucleic Acid ?

1967 • 671 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Separation and properties of cellular and scrapie prion proteins.

1986 • 619 citations

Creutzfeldt‐Jakob disease: Patterns of worldwide occurrence and the significance of familial and sporadic clustering

1979 • 618 citations

Restriction sites containing CpG show a higher frequency of polymorphism in human DNA

1984 • 586 citations

CREUTZFELDT-JAKOB DISEASE VIRUS ISOLATIONS FROM THE GERSTMANN-STRÄUSSLER SYNDROME

1981 • 534 citations

Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein

1990 • 531 citations

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.

1990 • 510 citations

Heterogeneity in dementia of the Alzheimer type: Evidence of subgroups

1985 • 507 citations

ENCEPHALOPATHY IN MICE PRODUCED BY INOCULATION WITH SCRAPIE BRAIN MATERIAL

1961 • 505 citations

Slow transmissible diseases of the nervous system

1979 • 503 citations

Purification and structural studies of a major scrapie prion protein

1984 • 497 citations

Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

1985 • 490 citations

Distinct prion proteins in short and long scrapie incubation period mice

1987 • 482 citations

Abnormal fibrils from scrapie-infected brain

1981 • 473 citations

The Method of Multiple Working Hypotheses

1890 • 470 citations

Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids.

1987 • 469 citations

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

1990 • 466 citations

Further purification and characterization of scrapie prions

1982 • 464 citations

Scrapie prion proteins are synthesized in neurons.

1986 • 422 citations

Linkage of prion protein and scrapie incubation time genes

1986 • 405 citations

The exceptionally small size of the scrapie agent

1966 • 403 citations

Creutzfeldt‐Jakob disease: Clinical analysis of a consecutive series of 230 neuropathologically verified cases

1986 • 400 citations

A4 amyloid protein deposition and the diagnosis of Alzheimer's disease

1988 • 367 citations

Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins

1988 • 366 citations

Homozygotes for Huntington's disease

1987 • 356 citations

Scrapie infectivity, fibrils and low molecular weight protein

1983 • 345 citations

Pathogenesis of Scrapie Virus Infection in the Mouse

1967 • 342 citations

Measurement of the scrapie agent using an incubation time interval assay

1982 • 339 citations

Molecular Cloning of a Human Prion Protein cDNA

1986 • 337 citations

Purification and properties of the cellular and scrapie hamster prion proteins

1988 • 330 citations

Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells

1989 • 330 citations

Extensive editing of the cytochrome c oxidase III transcript in Trypanosoma brucei

1988 • 325 citations

Stones in the kidney and ureter.

1948 • 323 citations

The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP).

1986 • 322 citations

Biological Evidence that Scrapie Agent Has an Independent Genome

1987 • 320 citations

The Method of Multiple Working Hypotheses

1998 • 312 citations

Characteristics of a Short Incubation Model of Scrapie in the Golden Hamster

1977 • 310 citations

Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease.

1987 • 307 citations

Two alleles of a neural protein gene linked to scrapie in sheep.

1990 • 301 citations

Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein

1989 • 300 citations

Identification of prion amyloid filaments in scrapie-infected brain

1985 • 293 citations

Correlation between Scores for Dementia and Counts of ‘Senile Plaques’ in Cerebral Grey Matter of Elderly Subjects

1966 • 293 citations

Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library.

1988 • 286 citations

Pathology of Kuru.

1959 • 284 citations

Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells.

1990 • 279 citations

Mutation of the Prion Protein in Libyan Jews with Creutzfeldt–Jakob Disease

1991 • 273 citations

The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene

1987 • 271 citations

Asparagine-linked glycosylation of the scrapie and cellular prion proteins

1989 • 268 citations

Pro→Leu change at position 102 of prinon protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome

1989 • 268 citations

Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C

1990 • 263 citations

Detection of Viral Nucleic Acids by in Situ Hybridization

1984 • 262 citations

Biochemistry of Altered Brain Proteins in Alzheimer's Disease

1989 • 261 citations

Antibodies to a scrapie prion protein

1984 • 260 citations

Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis

1991 • 259 citations

Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndrome

1989 • 254 citations

Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.

1988 • 254 citations

Evidence that the Transmission of One Source of Scrapie Agent to Hamsters Involves Separation of Agent Strains from a Mixture

1978 • 250 citations

Absence of Linkage of Chromosome 21q21 Markers to Familial Alzheimer's Disease

1988 • 245 citations

Temporary and Permanent Modifications to a Single Strain of Mouse Scrapie on Transmission to Rats and Hamsters

1987 • 240 citations

SCRAPIE PRIONS

1989 • 239 citations

THE FAMILIAL OCCURRENCE OF CREUTZFELDT-JAKOB DISEASE AND ALZHEIMER'S DISEASE

1981 • 233 citations

Assignment of the human and mouse prion protein genes to homologous chromosomes.

1986 • 233 citations

Fibrils from brains of cows with new cattle disease contain scrapie-associated protein

1988 • 233 citations

Scrapie PrP 27-30 is a sialoglycoprotein

1985 • 231 citations

Prion dementia without characteristic pathology

1990 • 230 citations

Rapid detection of Creutzfeldt‐Jakob disease and scrapie prion proteins

1990 • 217 citations

Molecular properties, partial purification, and assay by incubation period measurements of the hamster scrapie agent

1980 • 214 citations

Infection-Specific Particle from the Unconventional Slow Virus Diseases

1984 • 214 citations

Editing of kinetoplastid mitochondrial mRNAs by uridine addition and deletion generates conserved amino acid sequences and AUG initiation codons

1988 • 213 citations

Scrapie agent contains a hydrophobic protein.

1981 • 211 citations

Immunoaffinity purification and neutralization of scrapie prion infectivity.

1988 • 205 citations

Characterization of Scrapie Infection in Mouse Neuroblastoma Cells

1987 • 199 citations

Genetics of cancer predisposition.

1987 • 199 citations

Creutzfeldt–Jakob Disease Prion Proteins in Human Brains

1985 • 197 citations

Prions and Neurodegenerative Diseases

1987 • 197 citations

Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents

1979 • 193 citations

Spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie-affected sheep

1972 • 186 citations

Purified prion proteins and scrapie infectivity copartition into liposomes.

1987 • 186 citations

Scrapie: A transmissible and hereditary disease of sheep

1962 • 185 citations

Scrapie in Mice: Ultrastructural Observations in the Cerebral Cortex

1968 • 185 citations

Clinical and Pathological Features and Laboratory Confirmation of Creutzfeldt–Jakob Disease in a Recipient of Pituitary-Derived Human Growth Hormone

1985 • 178 citations

Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent.

1986 • 176 citations

McAlpine's Multiple sclerosis

1985 • 175 citations

Amyloid plaques in Creutzfeldt‐Jakob disease stain with prion protein antibodies

1986 • 175 citations

Gerstmann‐Sträussler‐Scheinker disease II. Neurofibrillary tangles and plaques with PrP‐amyloid coexist in an affected family

1989 • 173 citations

Nature of the Scrapie Agent

1967 • 172 citations

Identification of glycoinositol phospholipid-linked and truncated forms of the scrapie prion protein

1990 • 171 citations

Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation.

1990 • 170 citations

Proteinase‐resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity

1991 • 167 citations

Evidence for and against the transmissibility of Alzheimer disease

1980 • 166 citations

Creutzfeldt-Jakob disease in England and Wales, 1980-1984: a case-control study of potential risk factors.

1988 • 166 citations

Genetic Aspects of Unconventional Virus Infections: The Basis of the Virino Hypothesis

2007 • 164 citations

The possible nature of the transmissible agent of scrapie

1967 • 164 citations

Genetic linkage studies in Alzheimer's disease families

1988 • 163 citations

Encephalopathy of mink: I. Epizootiologic and clinical observations

1965 • 163 citations

Scrapie infectious agent is virus-like in size and susceptibility to inactivation

1984 • 161 citations

Linkage of the Scrapie-associated Fibril Protein (PrP) Gene and Sinc Using Congenic Mice and Restriction Fragment Length Polymorphism Analysis

1987 • 159 citations

Comparison of Scrapie and Transmissible Mink Encephalopathy in Hamsters. II. Clinical Signs, Pathology, and Pathogenesis

1975 • 159 citations

Prion-Protein Immunoreactivity in Human Transmissible Dementias

1986 • 157 citations

Inherited human prion diseases

1990 • 157 citations

Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time.

1988 • 157 citations

Transmissible and non-transmissible amyloidoses: autocatalytic post-translational conversion of host precursor proteins to β-pleated sheet configurations

1988 • 155 citations

Diagnosis of Creutzfeldt-Jakob Disease by Western Blot Identification of Marker Protein in Human Brain Tissue

1986 • 154 citations

Creutzfeldt-Jakob Disease: Focus among Libyan Jews in Israel

1974 • 152 citations

Molecular characteristics of the major scrapie prion protein

1984 • 152 citations

DIAGNOSIS OF GERSTMANN-STRÄUSSLER SYNDROME IN FAMILIAL DEMENTIA WITH PRION PROTEIN GENE ANALYSIS

1989 • 148 citations

Isolation and structural studies of the intact scrapie agent protein

1987 • 146 citations

Viroids and prions.

1982 • 145 citations

Creutzfeldt‐Jakob disease of long duration: Clinicopathological characteristics, transmissibility, and differential diagnosis

1984 • 142 citations

Maternal and lateral transmission of scrapie in sheep

1974 • 140 citations

Advances in veterinary research.

1946 • 138 citations

Linkage of the gene for the scrapie-associated fibril protein (PrP) to the Sip gene in Cheviot sheep

1989 • 137 citations

Unusual Topogenic Sequence Directs Prion Protein Biogenesis

1990 • 137 citations

Scrapie prion liposomes and rods exhibit target sizes of 55,000 Da

1988 • 136 citations

Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein

1990 • 132 citations

Molecular pathology of scrapie‐associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie

1988 • 131 citations

Creutzfeldt‐Jakob disease presenting as isolated aphasia

1989 • 128 citations

Monoclonal Antibodies to the Cellular and Scrapie Prion Proteins

1986 • 127 citations

Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues.

1986 • 126 citations

Slow virus diseases of animals and man

1977 • 124 citations

Unusual resistance to ionizing radiation of the viruses of kuru, Creutzfeldt-Jakob disease, and scrapie.

1978 • 123 citations

Transmission of bovine spongiform encephalopathy to mice

1988 • 122 citations

Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]

1987 • 119 citations

Purified scrapie prions resist inactivation by UV irradiation

1987 • 118 citations

DEGENERATION OF THE CEREBELLAR AND HYPOTHALAMO NEUROHYPOPHYSIAL SYSTEMS IN SHEEP WITH SCRAPIE; AND ITS RELATIONSHIP TO HUMAN SYSTEM DEGENERATIONS

1964 • 117 citations

Evidence suggesting that PrP is not the infectious agent in Creutzfeldt-Jakob disease.

1987 • 116 citations

Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones

1988 • 115 citations

AMYLOID PLAQUES IN THE BRAINS OF MICE INFECTED WITH SCRAPIE: MORPHOLOGICAL VARIATION AND STAINING PROPERTIES

1975 • 113 citations

Infectious Etiology of Neuritic (Senile) Plaques in Mice

1975 • 113 citations

Search for a Putative Scrapie Genome in Purified Prion Fractions Reveals a Paucity of Nucleic Acids

1991 • 111 citations

Subviral Pathogens of Plants and Animals: Viroids and Prions

1985 • 108 citations

Molecular mass, biochemical composition, and physicochemical behavior of the infectious form of the scrapie precursor protein monomer.

1990 • 108 citations

[6] Molecular weight determinations from radiation inactivation

1985 • 107 citations

Novel infectious agents and the central nervous system.

1988 • 102 citations

The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells

1990 • 102 citations

Partial purification and evidence for multiple molecular forms of the scrapie agent

1978 • 101 citations

Thiocyanate and hydroxyl ions inactivate the scrapie agent.

1981 • 100 citations

Identification of cellular proteins binding to the scrapie prion protein

1990 • 98 citations

An analysis of natural scrapie in suffolk sheep

1965 • 98 citations

Evidence for a secretory form of the cellular prion protein

1987 • 98 citations

Virus-Like Sensitivity of the Scrapie Agent to Heat Inactivation

1984 • 94 citations

Familial dementia with PrP‐positive amyloid plaques

1989 • 94 citations

Detection of Prion Protein mRNA in Normal and Scrapie-infected Tissues and Cell Lines

1988 • 91 citations

Detection of Scrapie-associated Fibril (SAF) Proteins Using Anti-SAF Antibody in Non-purified Tissue Preparations

1986 • 90 citations

Predicted secondary structure and membrane topology of the scrapie prion protein

1987 • 88 citations

Maximum Entropy Power Spectrum of Long Period Geomagnetic Reversals

1972 • 87 citations

Physical properties of the Creutzfeldt-Jakob disease agent

1989 • 87 citations

Three hamster species with different scrapie incubation times and neuropathological features encode distinct prion proteins.

1990 • 86 citations

Conservation of the cellular gene encoding the scrapie prion protein

1986 • 85 citations

Gerstmann‐Sträussler‐Scheinker disease. I. Extending the clinical spectrum

1989 • 84 citations

Further Observations on the Production of Scrapie in Sheep by Oral Dosing with Foetal Membranes from Scrapie-Affected Sheep

1974 • 84 citations

Scrapie: A Prototype Slow Infection

1972 • 83 citations

Intracellular accumulation of the cellular prion protein after mutagenesis of its Asnlinked glycosylation sites

1990 • 82 citations

Some Properties of the Scrapie Agent and Its Behavior in Mice

1963 • 82 citations

Scrapie: concept of a virus-induced amyloidosis of the brain.

1985 • 82 citations

An experimental examination of the scrapie agent in cell membrane mixtures

1971 • 82 citations

Immunoblotting of Creutzfeldt‐Jakob disease prion proteins: Host species—specific epitopes

1987 • 81 citations

CNS amyloid proteins in neurodegenerative diseases

1988 • 81 citations

Transmission of Scrapie in Hamsters

1985 • 78 citations

Antibodies to the scrapie protein decorate prion rods.

1985 • 76 citations

Primary structure of prion protein may modify scrapie isolate properties.

1989 • 75 citations

Is the Scrapie Agent a Viroid?

1972 • 74 citations

Bovine spongiform encephalopathy: detection and quantitation of fibrils, fibril protein (PrP) and vacuolation in brain

1990 • 74 citations

Modification of a Strain of Mouse-adapted Scrapie by Passage through Rats

1968 • 73 citations

Preliminary evidence of the experimental transmissibility of bovine spongiform encephalopathy to cattle.

1990 • 72 citations

Dietary transmission of bovine spongiform encephalopathy to mice.

1990 • 72 citations

Scrapie and Cellular Prion Proteins Share Polypeptide Epitopes

1986 • 70 citations

Replication of the Scrapie Agent in Hamsters Infected Intracerebrally Confirms the Pathogenesis of an Amyloid-inducing Virosis

1988 • 70 citations

Experimental transmission of an autosomal dominant spongiform encephalopathy: does the infectious agent originate in the human genome?

1985 • 69 citations

Properties of scrapie prion protein liposomes.

1988 • 69 citations

Aggregations of 35-Nanometer Particles Associated with Neuronal Cytopathic Changes in Natural Scrapie

1971 • 68 citations

Molecular Characteristics of Prion Rods Purified from Scrapie-Infected Hamster Brains

1986 • 67 citations

Search for a Scrapie‐Specific Nucleic Acid: A Progress Report

2007 • 66 citations

Electrophoretic properties of the scrapie agent in agarose gels.

1980 • 65 citations

Transmission experiments with multiple sclerosis: an interim report.

1966 • 65 citations

Geographical distribution of cases of Creutzfeldt-Jakob disease in England and Wales 1970-84.

1990 • 65 citations

Analysis of linkage between scrapie incubation period and the prion protein gene in mice

1990 • 64 citations

Immunoreactivity of a Synthetic Pentadecapeptide Corresponding to the N-Terminal Region of the Scrapie Prion Protein

1986 • 63 citations

Creutzfeldt-Jakob Disease: Hypothesis for High Incidence in Libyan Jews in Israel

1974 • 61 citations

Alzheimer's Disease

1966 • 60 citations

The physico-chemical nature of the scrapie agent.

1976 • 57 citations

Potential retroviral RNAs in Creutzfeldt-Jakob disease

1990 • 57 citations

Attempts to release the scrapie agent from tissue debris

1967 • 56 citations

Transmission studies from blood of Alzheimer disease patients and healthy relatives.

1988 • 56 citations

The molecular pathogenesis of astrogliosis in scrapie and Alzheimer's disease

1987 • 55 citations

Presence of mitochondrial D-loop DNA in scrapie-infected brain preparations enriched for the prion protein

1990 • 54 citations

Requirement of a Protein Component for Scrapie Infectivity

1980 • 53 citations

Reversible inactivation of pancreatic deoxyribonuclease A by sodium dodecyl sulfate. Removal of COOH-terminal residues from the denatured protein by carboxypeptidase A.

1975 • 53 citations

Radiation target analysis of glycoproteins

1986 • 52 citations

Sedimentation properties of the scrapie agent.

1977 • 52 citations

Descriptive Epidemiology of Creutzfeldt-Jakob Disease in Chile

1980 • 52 citations

Developmental expression of prion protein gene in brain

1987 • 51 citations

Vacuolar Change in Alzheimer's Disease

1987 • 51 citations

Fifty years with scrapie: a personal reminiscence.

1988 • 50 citations

In vitro expression in eukaryotic cells of a prion protein gene cloned from scrapie-infected mouse brain.

1988 • 50 citations

Amyloid plaques in spongiform encephalopathy of mule deer

1985 • 49 citations

Cerebellar plaques in familial Alzheimer's disease (Gerstmann-Str�ussler-Scheinker variant?)

1985 • 49 citations

PrP and the nature of the scrapie agent

1987 • 48 citations

Prion protein gene expression in cultured cells

1988 • 48 citations

Evidence of mitochondrial involvement in scrapie infection

1989 • 48 citations

Adenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transition

1991 • 47 citations

Unraveling prion diseases through molecular genetics

1989 • 46 citations

Scrapie : A modified membrane hypothesis

1968 • 46 citations

Slow, Latent and Temperate Virus Infections.

1967 • 46 citations

Evidence for an essential DNA component in the Scrapie agent

1978 • 45 citations

Evidence for the low molecular weight nature of scrapie agent

1979 • 45 citations

Coexistence of Creutzfeldt‐Jakob disease and Alzheimer's disease in the same patient

1990 • 44 citations

Evidence that DNA is present in abnormal tubulofilamentous structures found in scrapie.

1988 • 41 citations

Clinical similarity of Alzheimer and Creutzfeldt‐Jakob disease

1979 • 41 citations

An experimental examination of the scrapie agent in cell membrane mixtures

1971 • 41 citations

Occurrence of 14 cases of bovine spongiform encephalopathy in a closed dairy herd

1989 • 40 citations

Partial purification of the scrapie agent from mouse brain by pressure disruption and zonal centrifugation in sucrose-sodium chloride gradients

1976 • 40 citations

Properties of the scrapie agent-endomembrane complex from hamster brain

1976 • 39 citations

Cerebrospinal fluid neurochemistry in the myoclonic subtype of Alzheimer's disease

1988 • 39 citations

Progress in Neuropathology, Vol 5

1983 • 39 citations

Transmissible and non-transmissible neurodegenerative disease: similarities in age of onset and genetics in relation to aetiology

1986 • 39 citations

The significance of astroglial hypertrophy in Scrapie, Kuru, Multiple Sclerosis and old age together with a note on the possible nature of the scrapie agent

1967 • 39 citations

THE INFECTIVE PROCESS IN SCRAPIE

1968 • 38 citations

An experimental examination of the scrapie agent in cell membrane mixtures

1971 • 38 citations

Spongiform encephalopathy found in cat

1990 • 37 citations

Susceptibility of Scrapie Agent to Ionizing Radiation

1969 • 37 citations

Creutzfeldt‐Jakob disease without periodic sharp wave complexes

1988 • 37 citations

Structural and Biochemical Evidence that Scrapie-associated Fibrils Assemble in vivo

1989 • 36 citations

Nuclease treatment results in high specific purification of Creutzfeldt-Jakob disease infectivity with a density characteristic of nucleic acid-protein complexes

1990 • 35 citations

The nature of the scrapie agent. A review of recent progress.

1970 • 35 citations

Virus-like particles in brain tissue from two patients with Creutzfeldt-Jakob disease

1971 • 34 citations

Cloning of rat "prion-related protein" cDNA.

1987 • 34 citations

[Association of Alzheimer's disease and Creutzfeldt-Jakob's disease (author's transl)].

1977 • 33 citations

The major protein of SAF is absent from spleen and thus not an essential part of the scrapie agent

1986 • 33 citations

The decline and fall of Creutzfeldt‐Jakob disease associated with human growth hormone therapy

1988 • 33 citations

Membrane-free scrapie activity

1978 • 31 citations

Tubulofilaments in negatively stained scrapie-infected brains: relationship to scrapie-associated fibrils.

1987 • 31 citations

Absence of Vertical Transmission of Subacute Spongiform Viral Encephalopathies in Experimental Primates

1981 • 29 citations

Abnormal Tubulovesicular Particles in Brains of Hamsters with Scrapie

1987 • 29 citations

William Hunting and The Veterinary Record

1988 • 28 citations

A study of the inheritance of susceptibility to bovine spongiform encephalopathy.

1990 • 27 citations

Descriptive epidemiology of Creutzfeldt-Jakob disease in Finland

1988 • 27 citations

Sheep disease in human clothing

1989 • 26 citations

Creutzfeldt-Jakob disease with plaques and paired helical filaments

1987 • 24 citations

Is the scrapie agent a virus?

1976 • 23 citations

Human Pituitary Growth Hormone (hGH) and Creutzfeldt-Jakob Disease: Results of an Epidemiological Survey in France, 1986

1988 • 23 citations

The molecular biology of scrapie: the last two years

1987 • 22 citations

Experiments on Maternal Transmission of Creutzfeldt-Jakob Disease in Guinea Pigs

1979 • 22 citations

The temperature dependence of radiation sensitivity of large molecules

1986 • 22 citations

The Implications of Sociobiology

1976 • 21 citations

Biology and Structure of Scrapie Prions

1986 • 20 citations

Isolation of 14-nm virus-like particles from mouse brain infected with scrapie agent

1975 • 20 citations

BIOLOGICAL PROPERTIES OF SCRAPIE: AN UNCONVENTIONAL SLOW VIRUS

1985 • 19 citations

Effect of Different Gradient Solutions on the Buoyant Density of Scrapie Infectivity

1978 • 18 citations

SCRAPIE : AN INFECTIVE PEPTIDE ?

1972 • 18 citations

Experimental Control of Cerebral Amyloid in Scrapie in Mice

1983 • 17 citations

Familial Alzheimer's Disease With Myoclonus and 'Spongy Change'

1988 • 17 citations

Virus-like particles from both control and scrapie-affected mouse brain

1977 • 16 citations

Molecular Genetics in the Pathology and Diagnosis of Retinoblastoma

1990 • 13 citations

Scrapie in the mouse.

1976 • 13 citations

CREUTZFELDT-JAKOB DISEASE

1989 • 10 citations

THE PRP GENE IN NATURAL SCRAPIE

1988 • 10 citations

‘Slow virus’ dementias: prion gene holds the key

1989 • 9 citations

An Attempt to Determine Whether Maternal Transmission of Scrapie Occurs in Mice

1971 • 9 citations

Patient Care in Neurosurgery, 3rd Ed. (Patient Care Series)

1991 • 9 citations

Effects of the Antiserum against a Fraction Enriched in Scrapie‐Associated Fibrils on the Scrapie Incubation Period in Mice

1988 • 9 citations

Synergy in Chemotherapy of Staphylococcal Infections

1938 • 8 citations

Antelopes die of "mad cow" disease

1990 • 8 citations

ATAXIAS AND TRANSMISSIBLE AGENTS

1967 • 7 citations

Evidence against Transmission of Scrapie by Animal House Fomites

1970 • 6 citations

RUBELLA VIRUS IN PLACENTA AND FŒTUS

1965 • 6 citations

International Review of Neurobiology: Vol. 7

1966 • 3 citations