The LDL Receptor Gene Family

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

The Genome Sequence of Drosophila melanogaster

2000 • 5,882 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Wnt signaling and cancer

2000 • 3,215 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

1995 • 1,720 citations

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

1993 • 1,578 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

1984 • 1,386 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1999 • 1,311 citations

LDL-receptor-related proteins in Wnt signal transduction

2000 • 1,305 citations

Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

1999 • 1,231 citations

How Cells Handle Cholesterol

2000 • 1,230 citations

STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)

1994 • 1,175 citations

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

1996 • 1,140 citations

An LDL-receptor-related protein mediates Wnt signalling in mice

2000 • 1,080 citations

An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3

1999 • 989 citations

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

1988 • 947 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation

1999 • 902 citations

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

2000 • 870 citations

Reelin Is a Ligand for Lipoprotein Receptors

1999 • 803 citations

Defective Cholesterol Biosynthesis Associated with the Smith-Lemli-Opitz Syndrome

1994 • 802 citations

Neuronal position in the developing brain is regulated by mouse disabled-1

1997 • 698 citations

Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice

1997 • 637 citations

Reelin Binds α3β1 Integrin and Inhibits Neuronal Migration

2000 • 564 citations

Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family.

1994 • 550 citations

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

1992 • 548 citations

Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

1998 • 544 citations

Two new mutants, ‘trembler’ and ‘reeler’, with neurological actions in the house mouse (Mus musculus L.)

1951 • 517 citations

A LIS1/NUDEL/Cytoplasmic Dynein Heavy Chain Complex in the Developing and Adult Nervous System

2000 • 506 citations

Integrin signalling and tyrosine phosphorylation: just the FAKs?

1998 • 502 citations

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1995 • 493 citations

Defective forebrain development in mice lacking gp330/megalin.

1996 • 485 citations

NUDEL Is a Novel Cdk5 Substrate that Associates with LIS1 and Cytoplasmic Dynein

2000 • 482 citations

Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction

2000 • 458 citations

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.

1998 • 454 citations

Diversity Revealed by a Novel Family of Cadherins Expressed in Neurons at a Synaptic Complex

1998 • 446 citations

Reelin-induced tryosine phosphorylation of Disabled 1 during neuronal positioning

1999 • 407 citations

Human Apolipoprotein E Receptor 2

1996 • 378 citations

Mutations in the Δ7-sterol reductase gene in patients with the Smith–Lemli–Opitz syndrome

1998 • 371 citations

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

2001 • 370 citations

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

1987 • 355 citations

Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex

1999 • 344 citations

Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist

1994 • 311 citations

Roles of Wnt proteins in neural development and maintenance

2000 • 311 citations

Inhibition of GSK-3β leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium

1998 • 307 citations

Essential role of α6 integrins in cortical and retinal lamination

1998 • 301 citations

LIS1 Regulates CNS Lamination by Interacting with mNudE, a Central Component of the Centrosome

2000 • 296 citations

Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation

2000 • 285 citations

Mutational analysis of the ligand binding domain of the low density lipoprotein receptor.

1988 • 281 citations

Proteins of the CNR Family Are Multiple Receptors for Reelin

1999 • 276 citations

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

1995 • 270 citations

Genetics of ventral forebrain development and holoprosencephaly

2000 • 264 citations

Aberrant Splicing of a Mouse disabled Homolog, mdab1, in the scrambler Mouse

1997 • 263 citations

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

1995 • 259 citations

Knockout of the abetalipoproteinemia gene in mice: Reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes

1998 • 258 citations

Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development

2000 • 258 citations

The Reelin Receptor ApoER2 Recruits JNK-interacting Proteins-1 and -2

2000 • 245 citations

Molecular Characterization of a Novel Human Hybrid-type Receptor That Binds the α2-Macroglobulin Receptor-associated Protein

1996 • 236 citations

Apolipoprotein E receptors: linking brain development and alzheimer's disease

2000 • 218 citations

Lipoprotein receptors: new roles for ancient proteins

1999 • 218 citations

Cloning of a novel member of the low-density lipoprotein receptor family

1998 • 217 citations

Isolation and Characterization ofLRP6,a Novel Member of the Low Density Lipoprotein Receptor Gene Family

1998 • 207 citations

Elements of Neural Adhesion Molecules and a Yeast Vacuolar Protein Sorting Receptor Are Present in a Novel Mammalian Low Density Lipoprotein Receptor Family Member

1996 • 201 citations

The endocytic receptor protein LRP also mediates neuronal calcium signaling via N -methyl- <scp>d</scp> -aspartate receptors

2000 • 186 citations

The Reeler Mouse as a Model of Brain Development

1998 • 181 citations

Phosphorylation of human tau protein by microtubule-associated kinases: GSK3? and cdk5 are key participants

2000 • 173 citations

Identification of High-Molecular-Weight Proteins with Multiple EGF-like Motifs by Motif-Trap Screening

1998 • 172 citations

Brain Development in Normal and reeler Mice: the Phenotype

1998 • 165 citations

Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and Matrigel invasion

2000 • 164 citations

Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration

1996 • 154 citations

A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice

1996 • 148 citations

Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS

1999 • 147 citations

Role of Urokinase Receptor and Caveolin in Regulation of Integrin Signaling

1999 • 145 citations

Identification of Reelin-induced Sites of Tyrosyl Phosphorylation on Disabled 1

2001 • 136 citations

Cholesterol metabolism and embryogenesis

1998 • 134 citations

Regulation of the very low density lipoprotein receptor by thyroid hormone in rat skeletal muscle

1994 • 127 citations

Megalin Antagonizes Activation of the Parathyroid Hormone Receptor

1999 • 121 citations

Expression of the VLDL Receptor in Endothelial Cells

1996 • 119 citations

LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines.

2000 • 111 citations

Neurodegenerative Tauopathies

1999 • 110 citations

A New Low Density Lipoprotein Receptor Homologue with 8 Ligand Binding Repeats in Brain of Chicken and Mouse

1996 • 106 citations

The Low Density Lipoprotein Receptor Gene Family

1998 • 76 citations

Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator

2000 • 71 citations

Molecular Cloning and Characterization of LR3, a Novel LDL Receptor Family Protein with Mitogenic Activity

1998 • 69 citations

Correction: LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation

1993 • 65 citations

A Novel Mosaic Protein Containing LDL Receptor Elements Is Highly Conserved in Humans and Chickens

1997 • 64 citations

Expression of LR11, a Mosaic LDL Receptor Family Member, Is Markedly Increased in Atherosclerotic Lesions

1999 • 60 citations

Retroviral transfer of antisense integrin alpha6 or alpha8 sequences results in laminar redistribution or clonal cell death in developing brain.

1998 • 49 citations

A head-activator binding protein is present in hydra in a soluble and a membrane-anchored form

1999 • 46 citations

Retroviral Transfer of Antisense Integrin α6 or α8 Sequences Results in Laminar Redistribution or Clonal Cell Death in Developing Brain

1998 • 42 citations

The Role of the p35/cdk5 Kinase in Cortical Development

2000 • 28 citations

Developmental Regulation of LR11 Expression in Murine Brain

1998 • 26 citations

Differential Expression of LR11 during Proliferation and Differentiation of Cultured Neuroblastoma Cells

2000 • 24 citations

Function of the Neuropeptide Head Activator for Early Neural and Neuroendocrine Development

1999 • 10 citations