Activation and inhibition of lymphocytes by costimulation

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

2017 • 14,809 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

2001 • 916 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

Regulation of protein kinase cascades by protein phosphatase 2A

1999 • 798 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

Molecular Basis of T Cell Inactivation by CTLA-4

1998 • 678 citations

ICOS is essential for effective T-helper-cell responses

2001 • 666 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

ICOS is critical for CD40-mediated antibody class switching

2001 • 646 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

1996 • 529 citations

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

2000 • 507 citations

B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

1999 • 440 citations

The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function

2001 • 413 citations

CD28/B7 Regulation of Th1 and Th2 Subsets in the Development of Autoimmune Diabetes

1996 • 379 citations

On guard—activating NK cell receptors

2001 • 350 citations

T cell co-stimulatory molecules other than CD28

1999 • 349 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

Functional Responses and Costimulator Dependence of Memory CD4+ T Cells

2000 • 318 citations

The CD28 and CTLA-4 Receptors Associate with the Serine/Threonine Phosphatase PP2A

2000 • 287 citations

Immunoreceptor tyrosine-based inhibition motifs

1997 • 279 citations

CTLA-4 (CD152) Can Inhibit T Cell Activation by Two Different Mechanisms Depending on Its Level of Cell Surface Expression

2000 • 259 citations

CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation

1999 • 259 citations

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

2000 • 241 citations

Characterization of Human Inducible Costimulator Ligand Expression and Function

2000 • 237 citations

Structural Analysis of CTLA-4 Function In Vivo

2000 • 236 citations

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

1999 • 219 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.

1998 • 198 citations

ITAMs versus ITIMs: striking a balance during cell regulation

2002 • 192 citations

ITAMs versus ITIMs: striking a balance during cell regulation

2002 • 168 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor ζ and ZAP70

1997 • 153 citations

Costimulation in antiviral immunity: differential requirements for CD4+ and CD8+ T cell responses

2000 • 148 citations

Genetic analysis of protein tyrosine phosphatases

1998 • 145 citations

Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS

2000 • 132 citations

ICOS Costimulation Requires IL-2 and Can Be Prevented by CTLA-4 Engagement

2001 • 127 citations

Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

1997 • 124 citations

Critical Requirement for the Membrane-Proximal Cytosolic Tyrosine Residue for CD28-Mediated Costimulation In Vivo

2001 • 97 citations

Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Engagement Delivers an Inhibitory Signal through the Membrane-Proximal Region in the Absence of the Tyrosine Motif in the Cytoplasmic Tail

1999 • 96 citations

Lymphocyte signalling: A coordinating role for Vav?

1998 • 88 citations

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4

2001 • 86 citations

Networking Rho Family GTPases in Lymphocytes

1998 • 82 citations

The Inhibitory Function of CTLA-4 Does Not Require Its Tyrosine Phosphorylation

2000 • 81 citations

Adapters in lymphocyte signaling

2002 • 71 citations

Adapters in lymphocyte signaling

2002 • 66 citations

Signaling through CD28/CTLA-4 family receptors: puzzling participation of phosphatidylinositol-3 kinase.

1996 • 59 citations

T cells: A proliferation of costimulatory molecules

2000 • 57 citations

Cutting Edge: Tyrosine-Independent Transmission of Inhibitory Signals by CTLA-4

2000 • 53 citations

Elevation of Intracellular Cyclic AMP Induces an Anergic-like State in Th1 Clones

1996 • 22 citations