CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

1994 • 519 citations

cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.

1990 • 218 citations

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4⁺ and CD8⁺ T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2

1996 • 218 citations

Negative Regulation of Raf-1 by Phosphorylation of Serine 621

1996 • 215 citations

Location of cAMP-Dependent Protein Kinase Type I with the TCR-CD3 Complex

1994 • 200 citations

Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytes

1991 • 130 citations

Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants

1996 • 128 citations

Alternative Splicing of the High Affinity cAMP-Specific Phosphodiesterase (PDE7A) mRNA in Human Skeletal Muscle and Heart

1997 • 110 citations

Protein kinase A type I antagonist restores immune responses of T cells from HIV‐infected patients

1998 • 107 citations

c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes

1995 • 106 citations

Induction of Phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in Human Peripheral Blood T-lymphocytes by 8-Bromo-cAMP and Gs-coupled Receptor Agonists

1998 • 101 citations

Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP.

1995 • 84 citations

Inhibition of T lymphocyte activation by cAMP is associated with down-regulation of two parallel mitogen-activated protein kinase pathways, the extracellular signal-related kinase and c-Jun N-terminal kinase.

1996 • 83 citations

Identification of Raf‐1 Ser⁶²¹ kinase activity from NIH 3T3 cells as AMP‐activated protein kinase

1997 • 61 citations

Activation of type I protein kinase A during receptor-mediated human T lymphocyte activation.

1996 • 34 citations