ITAMs versus ITIMs: striking a balance during cell regulation

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

Immune Inhibitory Receptors

2000 • 1,283 citations

Anti-inflammatory Activity of IVIG Mediated Through the Inhibitory Fc Receptor

2001 • 1,037 citations

REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS

1999 • 947 citations

Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis

2000 • 747 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

1996 • 625 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Cytoplasmic Domain Heterogeneity and Functions of IgG Fc Receptors in B Lymphocytes

1992 • 462 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Punctuated Evolution Caused by Selection of Rare Beneficial Mutations

1996 • 352 citations

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

1999 • 344 citations

Sequential Involvement of Lck and SHP-1 with MHC-Recognizing Receptors on NK Cells Inhibits FcR-Initiated Tyrosine Kinase Activation

1996 • 341 citations

Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation

1998 • 338 citations

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

2001 • 314 citations

The B Cell Antigen Receptor Complex: Association of Ig-α and Ig-β with Distinct Cytoplasmic Effectors

1992 • 307 citations

The RasGAP-Binding Protein p62dok Is a Mediator of Inhibitory FcγRIIB Signals in B Cells

2000 • 238 citations

The Inositol Phosphatase SHIP Inhibits Akt/PKB Activation in B Cells

1998 • 226 citations

SHIP Recruitment Attenuates FcγRIIB-Induced B Cell Apoptosis

1999 • 220 citations

Fcγ Receptor Iib–Deficient Mice Develop Goodpasture's Syndrome upon Immunization with Type IV Collagen

2000 • 207 citations

Signal Transduction by the High-Affinity Immunoglobulin E Receptor FcεRI: Coupling Form to Function

2001 • 206 citations

A Novel Phosphotyrosine Motif with a Critical Amino Acid at Position −2 for the SH2 Domain-mediated Activation of the Tyrosine Phosphatase SHP-1

1997 • 199 citations

Identification of an Immunoreceptor Tyrosine-Based Activation Motif of K1 Transforming Protein of Kaposi’s Sarcoma-Associated Herpesvirus

1998 • 192 citations

Role of the rasGAP-associated docking protein p62^dokin negative regulation of B cell receptor-mediated signaling

2000 • 178 citations

Epstein–Barr Virus Coopts Lipid Rafts to Block the Signaling and Antigen Transport Functions of the BCR

2001 • 159 citations

An Unusual Mechanism for Ligand Antagonism

1998 • 157 citations

A Dual Role for Src Homology 2 Domain–Containing Inositol-5-Phosphatase (Ship) in Immunity

2000 • 154 citations

Specific Dephosphorylation of the Lck Tyrosine Protein Kinase at Tyr-394 by the SHP-1 Protein-tyrosine Phosphatase

2001 • 146 citations

Antigens Varying in Affinity for the B Cell Receptor Induce Differential B Lymphocyte Responses

1998 • 143 citations

CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection

2000 • 137 citations

SLP-76 Is a Direct Substrate of SHP-1 Recruited to Killer Cell Inhibitory Receptors

1998 • 136 citations

A Balance between Positive and Negative Signals in Cytotoxic Lymphocytes Regulates the Polarization of Lipid Rafts during the Development of Cell-Mediated Killing

2000 • 134 citations

Killer Cell Inhibitory Receptor Recognition of Human Leukocyte Antigen (HLA) Class I Blocks Formation of a pp36/PLC-γ Signaling Complex in Human Natural Killer (NK) Cells

1996 • 133 citations

Association of SLP-65 / BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-α

2001 • 129 citations

Lymphocytes with a complex: adapter proteins in antigen receptor signaling

2000 • 127 citations

The LMP2A ITAM Is Essential for Providing B Cells with Development and Survival Signals In Vivo

2000 • 120 citations

Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail

2001 • 119 citations

Partially Phosphorylated T Cell Receptor ζ Molecules Can Inhibit T Cell Activation

1999 • 113 citations

Positive Selection Through a Motif in the αβ T Cell Receptor

1998 • 111 citations

B Cell Development Is Arrested at the Immature B Cell Stage in Mice Carrying a Mutation in the Cytoplasmic Domain of Immunoglobulin β

2000 • 109 citations

Cross-Antagonism of a T Cell Clone Expressing Two Distinct T Cell Receptors

1999 • 108 citations

Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

1999 • 100 citations

The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

2000 • 95 citations

The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion.

1995 • 94 citations

Molecular Basis of the Recruitment of the SH2 Domain-containing Inositol 5-Phosphatases SHIP1 and SHIP2 by FcγRIIB

2000 • 92 citations

Asymmetrical Phosphorylation and Function of Immunoreceptor Tyrosine-Based Activation Motif Tyrosines in B Cell Antigen Receptor Signal Transduction

1998 • 91 citations

gp49B1-αvβ3 interaction inhibits antigen-induced mast cell activation

2001 • 88 citations

ITAM Multiplicity and Thymocyte Selection

2000 • 81 citations

Critical Relationship Between TCR Signaling Potential and TCR Affinity During Thymocyte Selection

2000 • 67 citations

Targeting Src Homology 2 Domain-Containing Tyrosine Phosphatase (SHP-1) into Lipid Rafts Inhibits CD3-Induced T Cell Activation

2001 • 67 citations

Function of Cd3ε-Mediated Signals in T Cell Development

2000 • 66 citations

The Immunoglobulin (Ig)α and Igβ Cytoplasmic Domains Are Independently Sufficient to Signal B Cell Maturation and Activation in Transgenic Mice

1997 • 66 citations

LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate phosphatidylinositol 3-kinase

1998 • 66 citations

Expression of HLA class I-specific inhibitory receptors in human cytolytic T lymphocytes: a regulated mechanism that controls T-cell activation and function

2000 • 59 citations

Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses.

1996 • 58 citations

Immunoreceptor Tyrosine-Based Inhibitory Motifs on Activating Molecules

2000 • 46 citations

Cloning and Tyrosine Phosphorylation of a Novel Invertebrate Immunocyte Protein Containing Immunoreceptor Tyrosine-based Activation Motifs

1997 • 16 citations