Alzheimer Disease: Basic and Clinical Advances

“Mini-mental state”

1975 • 82,784 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Diagnostic and Statistical Manual of Mental Disorders

2022 • 16,313 citations

The Brief Psychiatric Rating Scale

1962 • 10,683 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

1968 • 4,041 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

National Institutes of Health Consensus Development Conference Statement: Geriatric Assessment Methods for Clinical Decision‐making

1988 • 1,353 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Pathological verification of ischemic score in differentiation of dementias

1980 • 1,259 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

1989 • 1,128 citations

The Lewy body variant of Alzheimer's disease

1990 • 1,057 citations

The prevalence of dementia and Alzheimer's disease in Shanghai, China: Impact of age, gender, and education

1990 • 977 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Senile dementia of the Alzheimer type

1983 • 835 citations

Parent Care as a Normative Family Stress

1985 • 804 citations

Alzheimer's Disease

1986 • 772 citations

The Hidden Victims of Alzheimer's Disease: Families Under Stress

1985 • 760 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Clinico‐pathologic studies in dementia

1988 • 567 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease

1989 • 433 citations

Synaptic loss in Alzheimer's disease and other dementias

1989 • 406 citations

Behavioral Disturbance in Dementia of the Alzheimer's Type

1988 • 391 citations

A4 amyloid protein deposition and the diagnosis of Alzheimer's disease

1988 • 367 citations

Risk factors for clinically diagnosed Alzheimer's disease

1986 • 365 citations

Advances in Alzheimer's disease

1991 • 358 citations

Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

1989 • 353 citations

The Psychiatric Symptoms of Alzheimer's Disease

1988 • 311 citations

The promoter of Alzheimer's disease amyloid A4 precursor gene.

1988 • 309 citations

Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals

1988 • 270 citations

Prevalence of clinically diagnosed Alzheimer's disease and other dementing disorders

1990 • 268 citations

Women, myocardial infarction, and dementia in the very old

1990 • 252 citations

THE ASSOCIATION BETWEEN HEAD TRAUMA AND ALZHEIMER'S DISEASE

1990 • 251 citations

Decreased levels of protein kinase C in Alzheimer brain

1988 • 242 citations

Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques

1989 • 233 citations

Frequency and presentation of depressive symptoms in patients with primary degenerative dementia [published erratum appears in Am J Psychiatry 1987 Apr;144(4):542]

1987 • 201 citations

The precursor of Alzheimer??s disease amyloid A4 protein resembles a cell-surface receptor

1987 • 162 citations

Tricyclic Antidepressants in Depressed Patients With Cardiac Conduction Disease

1987 • 156 citations

Experimental Evaluation of the Effectiveness of Group Intervention for Dementia Caregivers

1987 • 156 citations

Comparison of rate of annual change of mental status score in four independent studies of patients with Alzheimer's disease

1988 • 144 citations

Neuropathological aspects of dementias resulting from abnormal blood and cerebrospinal fluid dynamics.

1976 • 135 citations

Pharmacologic Treatment of Agitation Associated With Dementia

1986 • 123 citations

Decreasing the Burden in Families Caring for a Relative With a Dementing Illness

1985 • 118 citations

A neuropathological subset of Alzheimer's disease with concomitant Lewy body disease and spongiform change

1989 • 114 citations

Aberrant casein kinase II in Alzheimer's disease

1990 • 107 citations

Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease.

1988 • 103 citations

Affective Disorders Arising in the Senium

1955 • 102 citations

The Yield of a Home Visit in the Assessment of Geriatric Patients

1989 • 99 citations

Tau Epitopes are Incorporated into a Range of Lesions in Alzheimerʼs Disease

1987 • 97 citations

The economic cost of senile dementia in the United States, 1985.

1988 • 88 citations

Neuroleptics and alternative treatments. Management of behavioral symptoms and psychosis in Alzheimer's disease and related conditions.

1988 • 82 citations

Neuroleptics and Alternative Treatments

1988 • 74 citations

The Brief Psychiatric Rating Scale (BPRS) in Geropsychiatric Research: II. Representative Profile Patterns

1984 • 55 citations

Biochemical Assay of Alzheimer's Disease—Associated Protein(s) in Human Brain Tissue

1990 • 50 citations

Incidence of orthostatic hypotension in patients with primary affective disorders treated with tricyclic antidepressants

1978 • 50 citations

Systemic manifestations of Alzheimer’s disease

1988 • 43 citations

Senile Dementia, Alzheimer's Type: The Family and the Health Care Delivery System

1981 • 34 citations

Should a major imaging procedure (CT or MRI) be required in the workup of dementia? An affirmative view.

1990 • 33 citations

An Outpatient Geriatric Psychiatry Assessment and Treatment Service

1987 • 23 citations

Reliability of drug histories in a specialized geriatric outpatient clinic

1989 • 22 citations

Epidemiology of dementia: cross-cultural comparisons.

1990 • 20 citations

Treatment Results at a Multi‐Specialty Clinic for the Impaired Elderly and Their Families*

1981 • 19 citations

STRUCTURE – FUNCTION CORRELATIONS IN ALZHEIMER DISEASE

1990 • 18 citations

Outpatient Geriatric Evaluation

1987 • 18 citations

Treatments for the Alzheimer Patient

1990 • 14 citations

Effect of age and dementia on the prevalence of cardiovascular disease

1990 • 10 citations

Linkage studies of late-onset familial Alzheimer's disease.

1990 • 7 citations