Post binding events in insulin action

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

1980 • 1,066 citations

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

1980 • 1,042 citations

Recycling receptors: The round-trip itinerary of migrant membrane proteins

1983 • 780 citations

Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

1979 • 701 citations

Journey to the Center of the Cell: Role of the Receptosome

1981 • 500 citations

Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity.

1981 • 456 citations

Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions

1983 • 432 citations

Major Human Erythrocyte Glycoprotein spans the Cell Membrane

1971 • 404 citations

Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

1978 • 372 citations

Mechanism of insulin action on glucose transport in the isolated rat adipose cell. Enhancement of the number of functional transport systems.

1978 • 330 citations

Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries.

1980 • 312 citations

Sugar transport in the red blood cell: structure-activity relationships in substrates and antagonists.

1961 • 301 citations

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

1982 • 287 citations

Clathrin-coated vesicles contain an ATP-dependent proton pump.

1983 • 284 citations

Glucose Uptake by Incubated Rat Epididymal Adipose Tissue

1965 • 260 citations

Hormone receptor topology and dynamics: Morphological analysis using ferritin-labeled epidermal growth factor

1979 • 254 citations

Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation.

1982 • 254 citations

An ATP-driven proton pump in clathrin-coated vesicles.

1983 • 253 citations

Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface

1979 • 237 citations

alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions.

1979 • 232 citations

Mechanisms of the ability of insulin to activate the glucose-transport system in rat adipocytes

1978 • 229 citations

The structure of insulin receptor and its subunits. Evidence for multiple nonreduced forms and a 210,000 possible proreceptor.

1982 • 225 citations

Binding and uptake of 125I-insulin into rat liver hepatocytes and endothelium. An in vivo radioautographic study.

1979 • 223 citations

Insulin Treatment Reverses the Insulin Resistance of Type II Diabetes Mellitus

1982 • 219 citations

Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.

1981 • 217 citations

Photoaffinity labeling of insulin receptor of rat adiopocyte plasma membrane.

1978 • 216 citations

Energy-dependent and protein synthesis-independent recycling of the insulin-sensitive glucose transport mechanism in fat cells.

1981 • 210 citations

On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell.

1981 • 198 citations

Photoaffinity labeling of insulin receptor proteins of liver plasma membrane preparations

1980 • 195 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

A possible mechanism of insulin resistance in the rat adipose cell in streptozotocin-induced diabetes mellitus. Depletion of intracellular glucose transport systems.

1981 • 176 citations

Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

1979 • 174 citations

Insulin Today

1977 • 172 citations

Reconstitution of D-glucose transport catalyzed by a protein fraction from human erythrocytes in sonicated liposomes.

1976 • 169 citations

Intracellular segregation of asialoglycoproteins and their receptor: a prelysosomal event subsequent to dissociation of the ligand-receptor complex.

1984 • 168 citations

A unique proteolytic cleavage site on the beta subunit of the insulin receptor.

1981 • 167 citations

Evidence for recycling of insulin receptors in isolated rat adipocytes.

1981 • 165 citations

Effects of Streptozotocin-induced Diabetes on Insulin Binding, Glucose Transport, and Intracellular Glucose Metabolism in Isolated Rat Adipocytes

1979 • 165 citations

Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

1979 • 161 citations

Internalized insulin receptors are recycled to the cell surface in rat hepatocytes.

1982 • 142 citations

Insulin-induced down-regulation of insulin receptors in 3T3-L1 adipocytes. Altered rate of receptor inactivation.

1982 • 139 citations

Differential effects of sulfhydryl reagents on activation and deactivation of the fat cell hexose transport system.

1976 • 132 citations

Coordinate modulation of D-glucose transport activity and bilayer fluidity in plasma membranes derived from control and insulin-treated adipocytes.

1980 • 128 citations

Photoaffinity labeling of insulin-sensitive hexose transporters in intact rat adipocytes. Direct evidence that latent transporters become exposed to the extracellular space in response to insulin.

1984 • 120 citations

Mechanism of Insulin-resistant Glucose Transport Activity in the Enlarged Adipose Cell of the Aged, Obese Rat

1982 • 117 citations

Surface binding and rates of internalization of 125I-insulin in adipocytes and IM-9 lymphocytes.

1982 • 116 citations

The monosaccharide transporter from human erythrocytes is heterogeneously glycosylated

1979 • 110 citations

Role of Glucose Transport in the Postreceptor Defect of Non-insulin-dependent Diabetes Mellitus

1982 • 106 citations

Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes.

1982 • 105 citations

Detection of the rat adipose cell glucose transporter with antibody against the human red cell glucose transporter

1982 • 103 citations

Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes.

1982 • 102 citations

Photoreactive insulin analogues used to characterise the insulin receptor

1980 • 101 citations

Coated vesicles participate in the receptor-mediated endocytosis of insulin.

1983 • 101 citations

Lysosomal Degradation of Receptor-bound 125I-labeled Insulin by Rat Adipocytes: Its Characterization and Dissociation from the Short-term Biologic Effects of Insulin

1980 • 96 citations

Evidence for different pathways for the degradation of insulin and insulin receptor in the chick liver cell.

1982 • 93 citations

Endocytosis of Peptide Hormones and Other Ligands

1982 • 90 citations

A Possible Mechanism of Insulin Resistance in the Rat Adipose Cell with High-Fat/Low-Carbohydrate Feeding: Depletion of Intracellular Glucose Transport Systems

1982 • 87 citations

Identification of the glucagon receptor in rat liver membranes by photoaffinity crosslinking

1981 • 86 citations

Internalization and molecular processing of insulin receptors in isolated rat adipocytes.

1982 • 81 citations

INSULIN CONTROLLING CALCIUM DISTRIBUTION IN MUSCLE AND FAT CELLS

1974 • 80 citations

Insulin Degradation by Hepatocytes in Primary Culture*

1981 • 78 citations

Inhibition of intracellular proteolysis by insulin in isolated rat hepatocytes. Possible role of internalized hormone.

1982 • 77 citations

Regulation of insulin receptor metabolism. Differentiation-induced alteration of receptor synthesis and degradation.

1981 • 76 citations

Inhibitors of 125I-epidermal growth factor internalization

1980 • 74 citations

Photolabeling of glucose-sensitive cytochalasin B binding proteins in erythrocyte, fibroblast and adipocyte membranes

1982 • 73 citations

Immunological identification of the human erythrocyte glucose transporter.

1980 • 72 citations

Quantitative ultrastructural analysis of receptor-mediated insulin uptake into adipocytes

1983 • 71 citations

Intracellular hormone receptors: evidence for insulin and lactogen receptors in a unique vesicle sedimenting in lysosome fractions of rat liver.

1981 • 70 citations

Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation

1979 • 66 citations

Purification and reconstitution of the adipocyte plasma membrane D-glucose transport system

1977 • 65 citations

Selective Effects of Inhibitors of Hormone Processing on Insulin Action in Isolated Hepatocytes*

1984 • 63 citations

The Endocytotic-Internalization Pathway of Insulin Metabolism: Relationship to Insulin Degradation and Activation of Glucose Transport*

1980 • 63 citations

Identification and characterization of a latent pool of insulin receptors in 3T3-L1 adipocytes.

1982 • 55 citations

Reconstituted D-glucose transport from the adipocyte plasma membrane. Chromatographic resolution of transport activity from membrane glycoproteins using immobilized concanavalin A

1980 • 55 citations

Physical and chemical studies on glycoproteins

1968 • 54 citations

Alkaline Phosphatase and Leucine Aminopeptidase Association in Plasma of the Chicken

1967 • 53 citations

Insulin Degradation by Liver Cell Membranes*

1979 • 53 citations

Role of intracellular energy in insulin's ability to activate 3-O-methylglucose transport by rat adipocytes

1980 • 50 citations

Covalent linking of photoreactive insulin to adipocytes produces a prolonged signal

1980 • 47 citations

Metabolism of photoaffinity-labeled insulin receptors by adipocytes. Role of internalization, degradation, and recycling.

1984 • 44 citations

Coupling of insulin receptors to glucose transport: A temperature-dependent time lag in activation of glucose transport

1979 • 44 citations

Primary amines do not prevent the endocytosis of epidermal growth factor into 3T3 fibroblasts

1981 • 43 citations

The Plasma Membrane of Isolated Fat Cells

1973 • 42 citations

The Role of Insulin Receptors and Receptor Antibodies in States of Altered Insulin Action

1979 • 40 citations

Kinetics of Insulin Receptor Biosynthesis and Membrane Insertion: Relationship to Cellular Function

1983 • 40 citations

Degradation of Insulin Receptors in Rat Adipocytes

1983 • 37 citations

Insulin-Stimulated Glucose Uptake by Subcellular Particles from Adipose Tissue Cells

1970 • 37 citations

Proposed mechanism of insulin-resistant glucose transport in the isolated guinea pig adipocyte. Small intracellular pool of glucose transporters.

1983 • 34 citations

A possible mechanism of insulin resistance in the rat adipose cell with high-fat/low-carbohydrate feeding. Depletion of intracellular glucose transport systems

1982 • 32 citations

Binding and Degradation of Semisynthetic Tritiated Insulin by IM-9 Cultured Human Lymphocytes

1980 • 31 citations

Insulin binding, internalization, and receptor regulation in cultured human fibroblasts

1981 • 31 citations

Coupling of insulin binding and insulin action on glucose transport in fat cells

1981 • 30 citations

Separate intracellular pathways for insulin receptor recycling and insulin degradation in isolated rat adipocytes

1983 • 27 citations

HORMONE ACTION AND RECEPTOR REDISTRIBUTION IN ENDOCRINE TARGET CELL: GONADOTROPINS AND GONADOTROPIN-RELEASING HORMONE

1981 • 27 citations

Relationship between deactivation of insulin-stimulated glucose transport and insulin dissociation in isolated rat adipocytes.

1980 • 25 citations

Identification and characterization of the rat adipocyte glucose transporter by photoaffinity crosslinking

1983 • 24 citations

Kinetic relationships between insulin receptor binding and effects on glucose transport in isolated rat adipocytes

1982 • 23 citations

Initial lag‐phase in the action of insulin on glucose transport and cAMP levels in fat cells

1978 • 22 citations

Comparison of the effects of insulin and H₂O₂ on adipocyte glucose transport

1982 • 20 citations

Binding and degradation of semisynthetic tritiated insulin by IM-9 cultured human lymphocytes

1980 • 14 citations

Structure and function relationships of insulin. Preparation, characterization, and biological activity of three bovine insulin derivatives selectively modified at the NH2-terminal of the B chain.

1979 • 14 citations

An improved and simplified apparatus for protein extraction and concentration from gel slices, using moving boundary electrophoresis

1983 • 13 citations

Length of Acute Exposure to Insulin Regulates the Rate of Deactivation of Stimulated Glucose Transport in Isolated Rat Adipocytes^*

1983 • 12 citations

Degradation of insulin receptors in rat adipocytes

1983 • 12 citations

Metabolic requirements for deactivation of insulin-stimulated glucose transport in isolated rat adipocytes

1981 • 9 citations

Selective inhibition by neuraminidase of insulin action on hexose metabolism of mouse adipocytes

1980 • 8 citations

Photoreactive Insulin Derivatives: Preparation and Characterization

1980 • 7 citations

Regulation of hexose transfer in giant muscle cells of the barnacle Balanus nubilus

1982 • 1 citations

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