Coupling of insulin binding and insulin action on glucose transport in fat cells

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

1980 • 1,066 citations

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

1980 • 1,042 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Direct demonstration that receptor crosslinking or aggregation is important in insulin action

1978 • 388 citations

Kinetic parameters of transport of 3-O-methylglucose and glucose in adipocytes.

1979 • 286 citations

The mobile receptor hypothesis and “cooperativity” of hormone binding. Application to insulin

1976 • 258 citations

Internalization of polypeptide hormones

1980 • 207 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

Actions of insulin in fat cells. Effects of low temperature, uncouplers of oxidative phosphorylation, and respiratory inhibitors.

1977 • 175 citations

Insulin Action and the Regulation of Hexose Transport

1980 • 170 citations

Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

1979 • 161 citations

Insulin-stimulated protein phosphorylation in 3T3-L1 preadipocytes.

1979 • 133 citations

Coordinate modulation of D-glucose transport activity and bilayer fluidity in plasma membranes derived from control and insulin-treated adipocytes.

1980 • 128 citations

Insulin effect on protein phosphorylation of plasma membranes and mitochondria in a subcellular system from rat adipocytes. I. Identification of insulin-sensitive phosphoproteins.

1979 • 93 citations

Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation

1979 • 66 citations

Insulin stimulation of glucose transport in adipose cells. An energy-dependent process

1977 • 65 citations

Action of insulin and catecholamines on the phosphorylation of proteins associated with the cytosol, membranes, and “fat cake” of rat fat cells.

1978 • 61 citations

Regulation of pyruvate dehydrogenase interconversion in isolated hepatocytes by the mitochondrial ATP/ADP ratio

1975 • 56 citations

Role of intracellular energy in insulin's ability to activate 3-O-methylglucose transport by rat adipocytes

1980 • 50 citations

An in Vitro system for studying insulin release caused by secretory granules‐plasma membrane interaction: definition of the system.

1976 • 48 citations

Coupling of insulin receptors to glucose transport: A temperature-dependent time lag in activation of glucose transport

1979 • 44 citations

Hormone control of plasma membrane oxidation—reduction reactions

1978 • 25 citations

Insulin activates pyruvate dehydrogenase by lowering the mitochondrial acetyl‐CoA/CoA ratio as evidenced by digitonin fraction of isolated fat cells

1978 • 23 citations

Initial lag‐phase in the action of insulin on glucose transport and cAMP levels in fat cells

1978 • 22 citations

Effect of colchicine and vinblastine on the coupling of insulin binding and insulin action in fat cells

1979 • 14 citations

Glucose‐induced first phase insulin release in the absence of extracellular Ca²⁺ in rat islets

1980 • 11 citations

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