Evidence for different pathways for the degradation of insulin and insulin receptor in the chick liver cell.

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

1974 • 1,481 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Isolation of the Insulin Receptor of Liver and Fat-Cell Membranes

1972 • 397 citations

Acetylcholine receptor turnover in membranes of developing muscle fibers.

1975 • 364 citations

Characteristics of the Human Lymphocyte Insulin Receptor

1973 • 320 citations

Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes.

1980 • 252 citations

Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells

1976 • 234 citations

Binding and uptake of 125I-insulin into rat liver hepatocytes and endothelium. An in vivo radioautographic study.

1979 • 223 citations

Intracellular Translocation of Iodine-125-Labeled Insulin: Direct Demonstration in Isolated Hepatocytes

1978 • 220 citations

On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell.

1981 • 198 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

1979 • 174 citations

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography.

1978 • 171 citations

Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action.

1977 • 171 citations

The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes

1979 • 157 citations

Lipogenesis and the synthesis and secretion of very low density lipoprotein by avian liver cells in nonproliferating monolayer culture. Hormonal effects.

1977 • 134 citations

An electron microscope autoradiographic study of the carbohydrate recognition systems in rat liver. II. Intracellular fates of the 125I-ligands.

1979 • 123 citations

Degradation of the acetylcholine receptor in cultured muscle cells: Selective inhibitors and the fate of undegraded receptors

1980 • 111 citations

Minireview: Mechanisms of protein turnover in cultured cells

1981 • 104 citations

Lysosomal Degradation of Receptor-bound 125I-labeled Insulin by Rat Adipocytes: Its Characterization and Dissociation from the Short-term Biologic Effects of Insulin

1980 • 96 citations

Mode of uptake and degradation of ¹²⁵I-labelled insulin by isolated hepatocytes and H4 hepatoma cells

1979 • 94 citations

Characterization of insulin-like actions of anti-insulin receptor antibodies. Effects on insulin binding, insulin degradation, and glycogen synthesis in isolated rat hepatocytes.

1980 • 86 citations

Regulation of insulin receptor metabolism. Differentiation-induced alteration of receptor synthesis and degradation.

1981 • 76 citations

Insulin binding to solubilized material from fat cell membranes: Evidence for two binding species

1978 • 75 citations

Functional relationships between insulin binding, action, and degradation. A reassessment.

1980 • 68 citations

Insulin degradation by insulin target cells

1981 • 56 citations

Effects of lysosomotropic agents, cytochalasin B and colchicine on the “down-regulation” of prolactin receptors in mammary gland explants

1980 • 54 citations

Degradation of 131I-Insulins by Rat Liver

1972 • 44 citations

An Evaluation of the Importance of Lysosomal and Neutral Cytosol Proteases in Insulin Degradation by Adipocytes*

1981 • 42 citations

Relationship of binding to internalization of125I-insulin in isolated rat hepatocytes

1979 • 30 citations

Immunochemical Studies on the Insulin-degrading Enzyme from Pig and Rat Skeletal Muscle

1980 • 21 citations

Inactivation of Insulin by Adipose Tissue

1965 • 20 citations

125I-Insulin is preferentially internalized in regions of the hepatocytes rich in lysosomal and Golgi structures

1979 • 13 citations