Mechanisms of TGF-β-Induced Cell Cycle Arrest

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

1995 • 956 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

1995 • 910 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Programmed cell death in plants: A pathogen-triggered response activated coordinately with multiple defense functions

1994 • 670 citations

Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β

1993 • 578 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding

1995 • 435 citations

Climate-related variations in denitrification in the Arabian Sea from sediment 15N/14N ratios

1995 • 433 citations

A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.

1994 • 332 citations

Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

1993 • 276 citations

Potential Role of WAF1/Cip1/p21 as a Mediator of TGF-β Cytoinhibitory Effect

1995 • 244 citations

Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest.

1991 • 203 citations

Transforming Growth Factor β Stabilizes p15^INK4B Protein, Increases p15^INK4B-cdk4 Complexes, and Inhibits Cyclin D1-cdk4 Association in Human Mammary Epithelial Cells

1997 • 196 citations

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

1995 • 162 citations

Transforming Growth Factor-β (TGF-β)-induced Down-regulation of Cyclin A Expression Requires a Functional TGF-β Receptor Complex

1995 • 154 citations

TGF-beta mediated G1 arrest in a human melanoma cell line lacking p15INK4B: evidence for cooperation between p21Cip1/WAF1 and p27Kip1.

1996 • 82 citations

TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.

1996 • 81 citations

Transforming growth factor beta 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcription.

1995 • 64 citations

TGF-beta 1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways.

1995 • 51 citations

The Growth-Inhibitory Block of TGF-β Is Located Close to the G1/S Border in the Cell Cycle

1995 • 44 citations

Inhibition of G1 phase cyclin dependent kinases by transforming growth factor β1

1994 • 38 citations

Inhibition of hepatocyte DNA synthesis by transforming growth factor beta 1 and cyclic AMP: effect immediately before the G1/S border.

1992 • 32 citations

Beyond PCR: Biotechnology as an Emerging Culture

1996 • 9 citations