Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1999 • 1,048 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Activation of Arp2/3 complex-mediated actin polymerization by cortactin

2001 • 561 citations

Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex.

1993 • 510 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

2000 • 454 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

Platelet Activation and Signal Transduction by Convulxin, a C-type Lectin from Crotalus durissus terrificus (Tropical Rattlesnake) Venom via the p62/GPVI Collagen Receptor

1997 • 345 citations

Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

1998 • 296 citations

Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily

2000 • 258 citations

Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization

2002 • 255 citations

Down-regulation of the Filamentous Actin Cross-linking Activity of Cortactin by Src-mediated Tyrosine Phosphorylation

1997 • 247 citations

Identification of a Central Phosphorylation Site in p21-activated Kinase Regulating Autoinhibition and Kinase Activity

1999 • 245 citations

The Mechanism of PAK Activation

2001 • 243 citations

Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation

1996 • 206 citations

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1

1998 • 197 citations

Characterization of Clostridium perfringens iota-toxin genes and expression in Escherichia coli

1993 • 174 citations

Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles

2000 • 169 citations

Phosphatidylinositol 3,4,5-Trisphosphate-dependent Stimulation of Phospholipase C-γ2 Is an Early Key Event in FcγRIIA-mediated Activation of Human Platelets

1998 • 165 citations

Adhesion and Activation of Human Platelets Induced by Convulxin Involve Glycoprotein VI and Integrin α2ॆ1

1997 • 161 citations

Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets

1995 • 132 citations

Structural Requirements for PAK Activation by Rac GTPases

1998 • 128 citations

Phosphorylation and reorganization of vimentin by p21‐activated kinase (PAK)

2002 • 113 citations

Purification of two high molecular weight toxins of Clostridium difficile which are antigenically related

1987 • 112 citations

The Fc Receptor for Immunoglobulin G (FcγRII) on Human Platelets

1995 • 108 citations

Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor

2000 • 90 citations

Rac, a small guanosine triphosphate–binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin α2β1

2001 • 84 citations

The Redistribution of Cortactin into Cell-Matrix Contact Sites in Human Carcinoma Cells with 11q13 Amplification Is Associated with Both Overexpression and Post-translational Modification

1997 • 68 citations

Characterisation of Rac activation in thrombin‐ and collagen‐stimulated human blood platelets

2001 • 65 citations

Bacterial toxins modifying the actin cytoskeleton.

1999 • 59 citations

PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac

2002 • 44 citations

Thrombopoietin stimulates cortactin translocation to the cytoskeleton independently of tyrosine phosphorylation

2001 • 17 citations

Kinetics of the Interaction of Myosin Subfragment-1 with G-Actin

1995 • 17 citations

Characterization of Clostridium perfringens Iota-toxin genes and expression in Escherichia coli

1995 • 17 citations