Heparanase-1 Gene Expression and Regulation by High Glucose in Renal Epithelial Cells

Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity.

1999 • 398 citations

The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices

1994 • 384 citations

Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase

1984 • 344 citations

A monoclonal antibody against GBM heparan sulfate induces an acute selective proteinuria in rats

1992 • 237 citations

Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior

2004 • 233 citations

Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.

1985 • 210 citations

Studies on Macromolecular Components of Human Glomerular Basement Membrane and Alterations in Diabetes: Decreased Levels of Heparan Sulfate Proteoglycan and Laminin

1987 • 208 citations

Effect of Diabetes on the Glycosaminoglycan Component of the Human Glomerular Basement Membrane

1982 • 203 citations

Expression of glomerular extracellular matrix components in human diabetic nephropathy: decrease of heparan sulphate in the glomerular basement membrane

1994 • 180 citations

Decreased de novo synthesis of glomerular proteoglycans in diabetes: biochemical and autoradiographic evidence.

1983 • 180 citations

Alterations in the Basement Membrane (Heparan Sulfate) Proteoglycan in Diabetic Mice

1982 • 176 citations

Heparanase-1 expression is associated with the metastatic potential of breast cancer

2002 • 152 citations

Heparan sulfate proteoglycan in the glomerular basement membrane in type 1 diabetes mellitus

1992 • 142 citations

Reduced synthesis of basement membrane heparan sulfate proteoglycan in streptozotocin-induced diabetic mice.

1983 • 130 citations

Glomerular Size and Charge Selectivity in the Mouse after Exposure to Glucosaminoglycan-Degrading Enzymes

2003 • 127 citations

CXC Chemokines Connective Tissue Activating Peptide-III and Neutrophil Activating Peptide-2 are Heparin/Heparan Sulfate-degrading Enzymes

1995 • 103 citations

Regulation of heparanase gene expression by estrogen in breast cancer.

2003 • 101 citations

Heparanase expression in invasive trophoblasts and acute vascular damage

2000 • 97 citations

[(35)S]sulfate incorporation into glomerular basement membrane glycosaminoglycans is decreased in experimental diabetes.

1981 • 95 citations

Studies on macromolecular components of human glomerular basement membrane and alterations in diabetes. Decreased levels of heparan sulfate proteoglycan and laminin

1987 • 88 citations

Heparanase Is Involved in the Pathogenesis of Proteinuria as a Result of Glomerulonephritis

2004 • 86 citations

Regulation of platelet heparanase during inflammation: Role of pH and proteinases

1998 • 81 citations

Cloning and Characterization of the Human Heparanase-1 (HPR1) Gene Promoter

2002 • 81 citations

Effect of diabetes on the glycosaminoglycan component of the human glomerular basement membrane

1982 • 77 citations

Involvement of human heparanase in the pathogenesis of diabetic nephropathy.

2002 • 69 citations

Increased expression of heparanase in puromycin aminonucleoside nephrosis

2001 • 68 citations

Heparan sulfate proteoglycans in experimental models of diabetes: a role for perlecan in diabetes complications

2001 • 65 citations

A Synthetic Heparanase Inhibitor Reduces Proteinuria in Passive Heymann Nephritis

2004 • 58 citations

Alterations in the basement membrane (heparan sulfate) proteoglycan in diabetic mice

1982 • 52 citations

Human mononuclear cells contain an endoglycosidase specific for heparan sulphate glycosaminoglycan demonstrable with the use of a specific solid-phase metabolically radiolabelled substrate

1989 • 45 citations

Subcellular localization of heparanase in human neutrophils

1992 • 43 citations

Inverse correlation between heparan sulfate composition and heparanase-1 gene expression in thyroid papillary carcinomas: a potential role in tumor metastasis.

2003 • 42 citations

Acidic and basic fibroblast growth factor bind with differing affinity to the same heparan sulfate proteoglycan on BALB/c 3T3 cells: Implications for potentiation of growth factor action by heparin

1995 • 21 citations

Platelet heparanase in vascular responses to xenotransplantation

2000 • 9 citations

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