Heparanase-1 expression is associated with the metastatic potential of breast cancer

Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis

1999 • 788 citations

Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis

2001 • 579 citations

Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer.

1994 • 573 citations

Heparanase: a key enzyme involved in cell invasion

2001 • 456 citations

Heparanase expression in primary and metastatic pancreatic cancer.

2001 • 236 citations

Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.

1985 • 210 citations

Expression of Heparanase in Normal, Dysplastic, and Neoplastic Human Colonic Mucosa and Stroma

2000 • 203 citations

MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial-mesenchymal transition traits.

2000 • 124 citations

CXC Chemokines Connective Tissue Activating Peptide-III and Neutrophil Activating Peptide-2 are Heparin/Heparan Sulfate-degrading Enzymes

1995 • 103 citations

Heparanase expression in invasive trophoblasts and acute vascular damage

2000 • 97 citations

Comprehensive Review of The Management of Internal Mammary Lymph Node Metastases in Breast Cancer

2001 • 83 citations

Model for breast cancer survival: relative prognostic roles of axillary nodal status, TNM stage, estrogen receptor concentration, and tumor necrosis.

1988 • 82 citations

Matrix Metalloproteinase-2 (MMP-2) is Associated with the Risk for a Relapse in Postmenopausal Patients with Node-Positive Breast Carcinoma Treated with Antiestrogen Adjuvant Therapy

2001 • 82 citations

c-myc, p53 andbcl-2, apoptosis-related genes in infiltrating breast carcinomas: Evidence of a link between bcl-2 protein over-expression and a lower risk of metastasis and death in operable patients

1999 • 58 citations

<i>bcl-2</i> Expression and Apoptosis in Primary and Metastatic Breast Carcinomas

2001 • 32 citations

Factors Correlating With Lymph Node Metastases in Patients With T1 Breast Cancer

2001 • 31 citations

Human Prostate Carcinoma Cells Produce Extracellular Heparanase

1997 • 30 citations

Morphological aspects of altered basement membrane metabolism in invasive carcinomas of the breast and the larynx.

1998 • 29 citations

Gene expression and protein deposition of major basement membrane components and TGF-beta 1 in human breast cancer.

1998 • 21 citations

Differential Heparanase-1 Expression in Malignant and Benign Pheochromocytomas

2002 • 18 citations