Heparan sulfate proteoglycans in experimental models of diabetes: a role for perlecan in diabetes complications

Functions of Cell Surface Heparan Sulfate Proteoglycans

1999 • 2,660 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

Diabetes mellitus and the risk of dementia

1999 • 2,031 citations

Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up Study

1974 • 1,629 citations

MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function

1998 • 1,623 citations

Albuminuria reflects widespread vascular damage

1989 • 1,390 citations

Diabetes and cardiovascular risk factors: the Framingham study.

1979 • 1,337 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Molecular diversity of heparan sulfate

2001 • 812 citations

Molecular diversity of heparan sulfate

2001 • 790 citations

Isolation of a heparan sulfate-containing proteoglycan from basement membrane.

1980 • 672 citations

Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

1999 • 672 citations

Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus

1987 • 671 citations

Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes

1999 • 665 citations

The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases

1996 • 601 citations

Diabetic Dyslipidemia: Causes and Consequences

2001 • 538 citations

Perlecan is essential for cartilage and cephalic development

1999 • 536 citations

The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule.

1991 • 446 citations

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

1988 • 410 citations

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

1996 • 334 citations

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

1996 • 282 citations

Lipoprotein Physiology in Nondiabetic and Diabetic States: Relationship to Atherogenesis

1991 • 281 citations

Experimental Galactosemia Produces Diabetic-like Retinopathy

1984 • 267 citations

Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone.

1987 • 260 citations

Perlecan Binds to the β‐Amyloid Proteins (Aβ) of Alzheimer's Disease, Accelerates Aβ Fibril Formation, and Maintains Aβ Fibril Stability

1997 • 251 citations

Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein containing lesions of Alzheimer's disease and Down's syndrome

1990 • 245 citations

Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes

1996 • 238 citations

DIABETIC NEPHROPATHY

1959 • 231 citations

Longitudinal association of vascular and Alzheimer's dementias, diabetes, and glucose tolerance

1999 • 227 citations

Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses

1989 • 211 citations

High affinity interactions between the Alzheimer's beta-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan

1991 • 211 citations

Polyantigenic Expansion of Basement Membrane Constituents in Diabetic Nephropathy

1983 • 207 citations

Effect of Diabetes on the Glycosaminoglycan Component of the Human Glomerular Basement Membrane

1982 • 203 citations

Expression of glomerular extracellular matrix components in human diabetic nephropathy: decrease of heparan sulphate in the glomerular basement membrane

1994 • 180 citations

Decreased de novo synthesis of glomerular proteoglycans in diabetes: biochemical and autoradiographic evidence.

1983 • 180 citations

Alterations in the Basement Membrane (Heparan Sulfate) Proteoglycan in Diabetic Mice

1982 • 176 citations

Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus.

1985 • 171 citations

Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects

1997 • 166 citations

Sequential alterations in glomerular prostaglandin and thromboxane synthesis in diabetic rats: Relationship to the hyperfiltration of early diabetes

1987 • 163 citations

Basement membrane abnormalities in human eyes with diabetic retinopathy.

1996 • 156 citations

Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model

1999 • 153 citations

The Protein Core of the Proteoglycan Perlecan Binds Specifically to Fibroblast Growth Factor-7

2000 • 143 citations

Heparan sulfate proteoglycan in the glomerular basement membrane in type 1 diabetes mellitus

1992 • 142 citations

Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.

1998 • 132 citations

Reduced synthesis of basement membrane heparan sulfate proteoglycan in streptozotocin-induced diabetic mice.

1983 • 130 citations

Structural characterization of the complete human perlecan gene and its promoter.

1993 • 130 citations

Agrin Is a Major Heparan Sulfate Proteoglycan Accumulating in Alzheimer's Disease Brain

1999 • 129 citations

Heparan sulfate proteoglycan in diffuse plaques of hippocampus but not of cerebellum in Alzheimer's disease brain.

1994 • 129 citations

Differential Binding of Vascular Cell-Derived Proteoglycans (Perlecan, Biglycan, Decorin, and Versican) to the Beta-Amyloid Protein of Alzheimer′s Disease

1995 • 127 citations

Altered Distribution of Basic Fibroblast Growth Factor in Diabetic Retinopathy

1991 • 127 citations

Triglyceride‐rich lipoproteins in non‐insulin‐dependent diabetes mellitus: post‐prandial metabolism and relation to premature atherosclerosis

1996 • 124 citations

ECM gene expression and its modulation by insulin in diabetic rats

1992 • 123 citations

Characterization of the Major Heparan Sulfate Proteoglycan Secreted by Bovine Aortic Endothelial Cells in Culture

1989 • 122 citations

Perlecan Heparan Sulfate Proteoglycan

2000 • 119 citations

The Mystery of Diabetes and Atherosclerosis: Time for a New Plot

1997 • 117 citations

Altered Steady-State mRNA Levels of Basement Membrane Proteins in Diabetic Mouse Kidneys and Thromboxane Synthase Inhibition

1990 • 115 citations

Reduced Sulfation of Liver Heparan Sulfate in Experimentally Diabetic Rats

1983 • 114 citations

An LRE (leucine-arginine-glutamate)-dependent mechanism for adhesion of neurons to S-laminin

1991 • 111 citations

Structural and Functional Characterization of the Human Perlecan Gene Promoter

1997 • 110 citations

Heparan sulfate proteoglycan expression in normal human liver

1995 • 99 citations

Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice

2000 • 98 citations

Fatty acids modulate the composition of extracellular matrix in cultured human arterial smooth muscle cells by altering the expression of genes for proteoglycan core proteins.

1999 • 97 citations

Stimulation of Retinal Capillary Pericyte Protein and Collagen Synthesis in Culture by High-Glucose Concentration

1984 • 95 citations

[(35)S]sulfate incorporation into glomerular basement membrane glycosaminoglycans is decreased in experimental diabetes.

1981 • 95 citations

Localization of the basement membrane heparan sulfate proteoglycan in islet amyloid deposits in type II diabetes mellitus.

1992 • 92 citations

Ultrastructural changes of extracellular matrices in diabetic nephropathy revealed by high resolution scanning and immunoelectron microscopy.

1993 • 88 citations

35S-Glycosaminoglycan and 35S-Glycopeptide Metabolism by Diabetic Glomeruli and Aorta

1982 • 80 citations

The effects of insulin, glucose and diabetes on prostaglandin production by rat kidney glomeruli and cultured glomerular mesangial cells

1983 • 79 citations

Human diabetic perineurial cell basement membrane thickening.

1981 • 78 citations

Relationship of sulfated glycosaminoglycans and cholesterol content in normal and arteriosclerotic human aorta.

1989 • 78 citations

Heparan Sulfate Proteoglycan-Mediated Uptake of Apolipoprotein E−Triglyceride-Rich Lipoprotein Particles: A Major Pathway at Physiological Particle Concentrations

1997 • 77 citations

Effect of diabetes on the glycosaminoglycan component of the human glomerular basement membrane

1982 • 77 citations

Distribution and origin of the basement membrane component perlecan in rat liver and primary hepatocyte culture.

1993 • 69 citations

The neuropathies of diabetes

1958 • 66 citations

Ultrastructure of Familial Amyloid Polyneuropathy Amyloid Fibrils: Examination with High-Resolution Electron Microscopy

1998 • 66 citations

Effects of high glucose on the production of heparan sulfate proteoglycan by mesangial and epithelial cells

1996 • 65 citations

Disturbances in Glomerular Basement Membrane Glycosaminoglycans in Experimental Diabetes

1987 • 64 citations

Localization of Glycosaminoglycan Substitution Sites on Domain V of Mouse Perlecan

1999 • 64 citations

Islet amyloid polypeptide in the islets of Langerhans: friend or foe?

2000 • 63 citations

Increased hyaluronan production in the glomeruli from diabetic rats: a link between glucose-induced prostaglandin production and reduced sulphated proteoglycan

1995 • 60 citations

Life without Perlecan Has Its Problems

1999 • 60 citations

Lipoprotein Modulation of Subendothelial Heparan Sulfate Proteoglycans (Perlecan) and Atherogenicity

2000 • 58 citations

Release of Glomerular Heparan-35SO4 Proteoglycan by Heparin From Glomeruli of Streptozocin-Induced Diabetic Rats

1989 • 53 citations

Decreased activity of the heparan sulfate-modifying enzyme glucosaminyl N-deacetylase in hepatocytes from streptozotocin-diabetic rats

1991 • 53 citations

Perlecan Mediates the Antiproliferative Effect of Apolipoprotein E on Smooth Muscle Cells

1999 • 51 citations

Glomerular Proteoglycans in Diabetes: Partial Structural Characterization and Metabolism of De Novo Synthesized Heparan-35SO4 and Dermatan-35SO4 Proteoglycans in Streptozocin-Induced Diabetic Rats

1986 • 51 citations

Triglyceride-rich lipoproteins and atherosclerosis: pathophysiological considerations.

1994 • 49 citations

Increased vasodilatory prostaglandin production in the diabetic rat retinal vasculature

1999 • 49 citations

LDL receptor–related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in LDLR-deficient mice

2001 • 48 citations

The mystery of diabetes and atherosclerosis: time for a new plot

1997 • 48 citations

Pathogenesis of Diabetic Vascular Disease: Evidence for the Role of Reduced Heparan Sulfate Proteoglycan

1997 • 48 citations

Visualization of the large heparan sulfate proteoglycan from basement membrane

1988 • 48 citations

Stimulation of retinal capillary pericyte protein and collagen synthesis in culture by high-glucose concentration

1984 • 47 citations

Characterization of heparan sulfate proteoglycan from calf lens capsule and proteoglycans synthesized by cultured lens epithelial cells. Comparison with other basement membrane proteoglycans

1991 • 45 citations

Altered steady-state mRNA levels of basement membrane proteins in diabetic mouse kidneys and thromboxane synthase inhibition

1990 • 43 citations

Heparan sulfate proteoglycan synthesis and its expression are decreased in the retina of diabetic rats

1997 • 42 citations

Elevated glucose decreases the content of a basement membrane associated heparan sulphate proteoglycan in proliferating cultured porcine mesangial cells

1992 • 38 citations

The Heparin-Binding Proteins Apolipoprotein E and Lipoprotein Lipase Enhance Cellular Proteoglycan Production

2000 • 37 citations

Perlecan inhibits smooth muscle cell adhesion to fibronectin: Role of heparan sulfate

2001 • 37 citations

Diabetes mellitus induced inhibition of glucosaminyl N-deacetylase: effect of short-term blood glucose control in diabetic rats

1993 • 35 citations

Albuminuria--a marker of renal and generalized vascular disease in insulin-dependent diabetes mellitus.

1991 • 35 citations

Plasma Lipid and Lipoprotein Disorders in IDDM

1992 • 34 citations

Disturbances in glomerular basement membrane glycosaminoglycans in experimental diabetes

1987 • 31 citations

The KKA<sup>y</sup> Mouse: A Model for the Rapid Development of Glomerular Capillary Basement Membrane Thickening

1987 • 30 citations

35S-glycosaminoglycan and 35S-glycopeptide metabolism by diabetic glomeruli and aorta

1982 • 30 citations

Immunohistochemical Quantification of Heparan Sulfate Proteoglycan and Collagen IV in Skeletal Muscle Capillary Basement Membranes of Patients With Diabetic Nephropathy

1997 • 28 citations

Effects of streptozotocin diabetes, glucose, and insulin on the metabolism of type IV collagen and proteoglycan in murine basement membrane-forming EHS tumor tissue.

1982 • 28 citations

Lipoprotein lipase release from BFC-1 beta adipocytes. Effects of triglyceride-rich lipoproteins and lipolysis products.

1992 • 27 citations

A CHARACTERISTIC BINDING AFFINITY BETWEEN HEPARAN SULFATE PROTEOGLYCANS AND THE A4 AMYLOID PROTEIN OF ALZHEIMERʼS DISEASE

1989 • 26 citations

Regulation of basement membrane heparan sulfate proteoglycan, perlecan, gene expression in glomerular epithelial cells by high glucose medium

1996 • 24 citations

Sulfate metabolism in the alloxan-diabetic rat: relationship of altered sulfate pools to proteoglycan sulfation in heart and other tissues

1987 • 21 citations

Cyclic AMP regulates basement membrane heparan sulfate proteoglycan, perlecan, metabolism in rat glomerular epithelial cells

1996 • 21 citations

Posttranscriptional effects of glucose on proteoglycan expression in mesangial cells

1996 • 18 citations

Role of fatty acids and eicosanoids in modulating proteoglycan metabolism in endothelial cells

1995 • 17 citations

Effect of Insulin on High-Glucose Medium-Induced Changes in Rat Glomerular Epithelial Cell Metabolism of Glycoconjugates

1995 • 16 citations

Proteoglycan synthesis by bovine myocardial endothelial cells is increased by long‐term exposure to high concentrations of glucose

1995 • 15 citations

Glomerular proteoglycans in diabetes. Partial structural characterization and metabolism of de novo synthesized heparan-35SO4 and dermatan-35SO4 proteoglycans in streptozocin-induced diabetic rats

1986 • 15 citations

Release of glomerular heparan-35SO4 proteoglycan by heparin from glomeruli of streptozocin-induced diabetic rats

1989 • 14 citations

Regulation of Rat Glomerular Epithelial Cell Proteoglycans by High-Glucose Medium

1994 • 12 citations

Micro- and macroangiopathies and other chronic degenerative complications in newly detected diabetes mellitus.

1980 • 11 citations

Lipid mediators that modulate the extracellular matrix structure and function in vascular cells

1999 • 11 citations

Influence of glucose on production and N-sulfation of heparan sulfate in cultured adipocyte cells.

2000 • 9 citations

Islet Amyloid Polypeptide (Amylin) Modulates Chylomicron Metabolism In Rats

2000 • 8 citations

A 66KD HEAT-STABLE NEURONAL PROTEIN REACTS WITH AN ANTISERUM TO THE BETA-AMYLOID PRECURSOR PROTEIN

1989 • 6 citations