Regulation of platelet heparanase during inflammation: Role of pH and proteinases

Cytokines and endothelial cell biology

1990 • 1,275 citations

The relevance of tumour pH to the treatment of malignant disease

1984 • 886 citations

Does superoxide underlie the pathogenesis of hypertension?

1991 • 760 citations

Increased permeability of the glomerular basement membrane to ferritin after removal of glycosaminoglycans (heparan sulfate) by enzyme digestion.

1980 • 650 citations

Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8.

1993 • 444 citations

Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

1993 • 412 citations

Heparanases and tumor metastasis

1988 • 303 citations

Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation.

1992 • 301 citations

Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection.

1990 • 274 citations

Heparanase activity expressed by platelets, neutrophils, and lymphoma cells releases active fibroblast growth factor from extracellular matrix.

1990 • 203 citations

Role of heparan sulfate in immune system-blood vessel interactions

1993 • 200 citations

Suramin. A potent inhibitor of melanoma heparanase and invasion

1991 • 174 citations

Purification and properties of human platelet heparitinase.

1982 • 154 citations

Inhibition of leucocyte elastase by heparin and its derivatives

1988 • 129 citations

Heparinase inhibitsneovascularization.

1994 • 117 citations

Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH.

1995 • 115 citations

Shedding of heparan sulfate proteoglycan by stimulated endothelial cells: Evidence for proteolysis of cell-surface molecules

1996 • 114 citations

Isolation, culture, and subculture of bovine pulmonary artery endothelial cells: Mechanical methods

1986 • 114 citations

Vascular bound recombinant extracellular superoxide dismutase type C protects against the detrimental effects of superoxide radicals on endothelium-dependent arterial relaxation.

1992 • 112 citations

Characterization of platelet endoglycosidase degrading heparin-like polysaccharides

1980 • 111 citations

Identification of porcine endothelial cell membrane antigens recognized by human xenoreactive natural antibodies.

1995 • 110 citations

Effect of a platelet endoglycosidase on cell surface associated heparan sulphate of human cultured endothelial and glial cells

1977 • 108 citations

CXC Chemokines Connective Tissue Activating Peptide-III and Neutrophil Activating Peptide-2 are Heparin/Heparan Sulfate-degrading Enzymes

1995 • 103 citations

Enzymatic depolymerization of heparin-related polysaccharides. Substrate specificities of mouse mastocytoma and human platelet endo-beta-D-glucuronidases.

1982 • 93 citations

A postulated mechanism for heparin's potentiation of C1 inhibitor function

1982 • 79 citations

Degradation of sulfated proteoglycans in the subendothelial extracellular matrix by human platelet heparitinase.

1984 • 78 citations

Vascular endothelial cell proteoglycans are susceptible to cleavage by neutrophils.

1992 • 74 citations

A disaccharide that inhibits tumor necrosis factor alpha is formed from the extracellular matrix by the enzyme heparanase.

1995 • 59 citations

Heparan sulfate initiates signals in murine macrophages leading to divergent biologic outcomes.

1995 • 59 citations

Regulation of murine splenocyte responses by heparan sulfate.

1991 • 57 citations

Role of Endothelial Cell Surface Heparin‐like Polysaccharidesa

1989 • 44 citations

Heparanase activity in cultured endothelial cells

1991 • 39 citations

MODULATION OF CYTOLYTIC T CELL RESPONSES BY HEPARAN SULFATE

1994 • 28 citations

Heparan Sulfate Species and Blood Vessel Wall Function

1987 • 27 citations

Inhibition of experimental metastasis and extracellular matrix degradation by butanol extracts from B16-F1 murine melanoma.

1989 • 23 citations

On physiological microthromboembolization as the primary platelet function: Elimination of invaded particles from the circulation and its pathogenic significance

1976 • 23 citations

MODULATION OF CYTOLYTIC T CELL RESPONSES BY HEPARAN SULFATE

1994 • 23 citations

Antithrombin III regulates complement activity in vitro.

1991 • 19 citations

Activation of platelet heparitinase by tumor cell-derived factors

1991 • 13 citations