Cloning and Characterization of the Human Heparanase-1 (HPR1) Gene Promoter

Changing views of the role of matrix metalloproteinases in metastasis

1997 • 1,585 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

The Sp-family of transcription factors

1999 • 1,098 citations

Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis

1999 • 788 citations

Sp1-mediated transcriptional activation is repressed by Sp3.

1994 • 692 citations

A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

1999 • 607 citations

Developmental Expression of Sp1 in the Mouse

1991 • 533 citations

Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis

1999 • 516 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

Heparan Sulfate Degradation: Relation to Tumor Invasive and Metastatic Properties of Mouse B16 Melanoma Sublines

1983 • 350 citations

Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase

1984 • 344 citations

Structure of the human type IV collagenase gene.

1990 • 310 citations

Heparanases and tumor metastasis

1988 • 303 citations

Human Heparanase

1999 • 297 citations

Transcriptional regulation by the Sp family proteins

1997 • 287 citations

Sp3 Is a Bifunctional Transcription Regulator with Modular Independent Activation and Repression Domains

1997 • 284 citations

Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.

1985 • 210 citations

cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

1990 • 202 citations

Cloning and Functional Expression of a Human Heparanase Gene

1999 • 199 citations

Cloning and Expression Profiling of Hpa2, a Novel Mammalian Heparanase Family Member

2000 • 186 citations

Critical determinants of cancer metastasis: rationale for therapy

1999 • 169 citations

Oncostatin M Stimulates Transcription of the Human α2(I) Collagen Gene via the Sp1/Sp3-binding Site

1997 • 140 citations

Sp3 is a transcriptional activator of the human 2(I) collagen gene

1997 • 107 citations

CXC Chemokines Connective Tissue Activating Peptide-III and Neutrophil Activating Peptide-2 are Heparin/Heparan Sulfate-degrading Enzymes

1995 • 103 citations

Identification of a serum- and phorbol ester-responsive element in the murine tissue inhibitor of metalloproteinase gene.

1991 • 98 citations

Heparanase expression in invasive trophoblasts and acute vascular damage

2000 • 97 citations

Sp1 Cooperates with the ets Transcription Factor, GABP, to Activate the CD18 (β2 Leukocyte Integrin) Promoter

1998 • 95 citations

GABP and PU.1 Compete for Binding, yet Cooperate to Increase CD18 (β2 Leukocyte Integrin) Transcription

1995 • 93 citations

The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements.

1994 • 92 citations

Ets transcription factors cooperate with Sp1 to activate the human Tenascin-C promoter

1999 • 84 citations

Insulin-like Growth Factor-I Regulates Transcription of the Elastin Gene through a Putative Retinoblastoma Control Element

1996 • 82 citations

Genomic organization and chromosome localization of the newly identified human heparanase gene

2000 • 81 citations

GABP Cooperates With c-Myb and C/EBP to Activate the Neutrophil Elastase Promoter

1997 • 79 citations

Combinatorial Action of HNF3 and Sp Family Transcription Factors in the Activation of the Rabbit Uteroglobin/CC10 Promoter

1998 • 74 citations

GA-binding Protein-dependent Transcription Initiator Elements

1997 • 58 citations

A solid-phase substrate of heparanase: Its application to assay of human melanoma for heparan sulfate degradative activity

1986 • 53 citations

Human mononuclear cells contain an endoglycosidase specific for heparan sulphate glycosaminoglycan demonstrable with the use of a specific solid-phase metabolically radiolabelled substrate

1989 • 45 citations

Transcriptional Regulation of Fas Gene Expression by GA-binding Protein and AP-1 in T Cell Antigen Receptor·CD3 Complex-stimulated T Cells

1999 • 45 citations

ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase beta-subunit.

1994 • 44 citations

Subcellular localization of heparanase in human neutrophils

1992 • 43 citations

The laminin B2 chain promoter contains unique repeat sequences and is active in transient transfection.

1988 • 40 citations

Tumor metastasis-associated heparanase (heparan sulfate endoglycosidase) activity in human melanoma cells

1986 • 37 citations

An Enhancer Located between the Neutrophil Elastase and Proteinase 3 Promoters Is Activated by Sp1 and an Ets Factor

1999 • 37 citations

Human HPA endoglycosidase heparanase. Map position 4q21.3.

1999 • 19 citations