Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

1995 • 1,436 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Endotoxin signal transduction in macrophages

1996 • 803 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Modulation of fibroblast proliferation by oxygen free radicals

1990 • 617 citations

Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase

1993 • 586 citations

Interleukin-1

1997 • 566 citations

Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes

1995 • 538 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

LPS-binding proteins and receptors

1998 • 480 citations

Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.

1996 • 475 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Lipopolysaccharide Induces Rac1-dependent Reactive Oxygen Species Formation and Coordinates Tumor Necrosis Factor-α Secretion through IKK Regulation of NF-κB

2001 • 394 citations

Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis

1996 • 381 citations

Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6.

1990 • 364 citations

The Lipopolysaccharide-activated Toll-like Receptor (TLR)-4 Induces Synthesis of the Closely Related Receptor TLR-2 in Adipocytes

2000 • 348 citations

Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.

1991 • 318 citations

Neutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly.

1998 • 314 citations

Both Erk and p38 Kinases Are Necessary for Cytokine Gene Transcription

1999 • 305 citations

Molecular mechanisms of endotoxin activity

1995 • 303 citations

LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-α

2000 • 302 citations

Cellular Events Mediated by Lipopolysaccharide-stimulated Toll-like Receptor 4

2000 • 269 citations

The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion

1994 • 266 citations

Signal transduction by reactive oxygen species in non-phagocytic cells

1999 • 264 citations

Inhibition of MAP Kinase Kinase Prevents Cytokine and Prostaglandin E2 Production in Lipopolysaccharide-Stimulated Monocytes

1998 • 255 citations

Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide

1997 • 249 citations

The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

1996 • 234 citations

Lipopolysaccharide Signals Activation of Tumor Necrosis Factor Biosynthesis Through the Ras/Raf-1/MEK/MAPK Pathway

1994 • 228 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

An automated micro-fluorometric assay for monitoring oxidative burst activity of phagocytes

1993 • 211 citations

Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes.

1996 • 210 citations

Ligands of Macrophage Scavenger Receptor Induce Cytokine Expression via Differential Modulation of Protein Kinase Signaling Pathways

2001 • 170 citations

Lipopolysaccharide Activates Caspase-1 (Interleukin-1–Converting Enzyme) in Cultured Monocytic and Endothelial Cells

1998 • 158 citations

Expression of Toll-Like Receptor 2 on γδ T Cells Bearing Invariant Vγ6/Vδ1 Induced byEscherichia coliInfection in Mice

2000 • 150 citations

Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes.

1994 • 146 citations

Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages.

1999 • 141 citations

Toll-like receptors: how they work and what they do

2002 • 138 citations

Metabolic Impairment Induces Oxidative Stress, Compromises Inflammatory Responses, and Inactivates a Key Mitochondrial Enzyme in Microglia

1999 • 137 citations

Regulation of the phagocyte respiratory burst by small GTP-binding proteins

1995 • 125 citations

Regulation of TNF Expression by Multiple Mitogen-Activated Protein Kinase Pathways

2000 • 123 citations

Evaluation of the Role of Mitogen-Activated Protein Kinases in the Expression of Inducible Nitric Oxide Synthase by IFN-γ and TNF-α in Mouse Macrophages

1999 • 119 citations

Lipopolysaccharide-induced inhibition of scavenger receptor expression in human monocyte-macrophages is mediated through tumor necrosis factor-alpha.

1992 • 115 citations

Electron Leakage from the Mitochondrial NADPH-Adrenodoxin Reductase-Adrenodoxin-P450scc (Cholesterol Side Chain Cleavage) System

1993 • 115 citations

Ligand Binding to Macrophage Scavenger Receptor-A Induces Urokinase-type Plasminogen Activator Expression by a Protein Kinase-dependent Signaling Pathway

1998 • 97 citations

Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-kappaB activation and reactive oxygen intermediates.

1999 • 88 citations

A CRE/ATF-Like Site in the Upstream Regulatory Sequence of the Human Interleukin 1β Gene Is Necessary for Induction in U937 and THP-1 Monocytic Cell Lines

1993 • 85 citations

Lipopolysaccharide Inhibits TNF-Induced Apoptosis: Role of Nuclear Factor-κB Activation and Reactive Oxygen Intermediates

1999 • 83 citations

Impaired Pulmonary NF-κB Activation in Response to Lipopolysaccharide in NADPH Oxidase-Deficient Mice

2001 • 80 citations

Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1.

1997 • 78 citations

Glutathione Levels Determine Apoptosis in Macrophages

1998 • 70 citations

Tumor Necrosis Factor-α-mediated Protein Kinases in Regulation of Scavenger Receptor and Foam Cell Formation on Macrophage

2000 • 59 citations

Role of Protein Kinase C in Basal and Hydrogen Peroxide-Stimulated NF-κB Activation in the Murine Macrophage J774A.1 Cell Line

1998 • 53 citations

The interleukin-1 and interleukin-1 converting enzyme families in the cardiovascular system.

1998 • 42 citations

Escherichia coli-induced activation of neutrophil NADPH-oxidase: lipopolysaccharide and formylated peptides act synergistically to induce release of reactive oxygen metabolites

1995 • 31 citations

Scavenger Receptors May Regulate Nitric Oxide Production from Macrophages Stimulated by LPS

1997 • 21 citations

Antioxidant enzymes in xeroderma pigmentosum fibroblasts.

1988 • 20 citations