Regulation of TNF Expression by Multiple Mitogen-Activated Protein Kinase Pathways

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures

1998 • 709 citations

Jun N-Terminal Kinase/Stress-Activated Protein Kinase (JNK/SAPK) Is Required for Lipopolysaccharide Stimulation of Tumor Necrosis Factor Alpha (TNF-α) Translation: Glucocorticoids Inhibit TNF-α Translation by Blocking JNK/SAPK

1997 • 497 citations

Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.

1990 • 495 citations

Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.

1996 • 475 citations

Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells

1997 • 466 citations

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast

1993 • 465 citations

Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

1992 • 402 citations

Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells

1998 • 335 citations

PRAK, a novel protein kinase regulated by the p38 MAP kinase

1998 • 327 citations

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1994 • 325 citations

Tails of RNA polymerase II

1990 • 320 citations

Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.

1993 • 302 citations

Splicing Factors Associate with Hyperphosphorylated RNA Polymerase II in the Absence of Pre-mRNA

1997 • 245 citations

The role of p38 mitogen-activated protein kinase in IL-1 beta transcription.

1999 • 241 citations

Construction and analysis of yeast RNA polymerase II CTD deletion and substitution mutations.

1995 • 239 citations

Apoptosis Signaling Pathway in T Cells Is Composed of ICE/Ced-3 Family Proteases and MAP Kinase Kinase 6b

1997 • 234 citations

Growth-related Changes in Phosphorylation of Yeast RNA Polymerase II

1998 • 225 citations

Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages.

1996 • 215 citations

The Role of p38 Mitogen-Activated Protein Kinase in IL-1β Transcription

1999 • 212 citations

Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase II.

1988 • 212 citations

The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.

1992 • 210 citations

CTD kinase associated with yeast RNA polymerase II initiation factor b

1991 • 199 citations

CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide.

1994 • 181 citations

Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing.

1993 • 175 citations

The p38 MAP Kinase Pathway and Its Biological Function

1998 • 162 citations

RNA polymerase II C-terminal domain required for enhancer-driven transcription

1995 • 155 citations

Interactive effects of the tumor necrosis factor promoter and 3'-untranslated regions.

1991 • 153 citations

Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes.

1994 • 146 citations

c-jun N-terminal kinase is involved in AUUUA-mediated interleukin-3 mRNA turnover in mast cells

1998 • 145 citations

DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats.

1992 • 133 citations

Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products.

1993 • 133 citations

A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liver.

1992 • 124 citations

Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events.

1995 • 115 citations

Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription

1997 • 111 citations

Modulation of RNA Polymerase II Elongation Efficiency by C-terminal Heptapeptide Repeat Domain Kinase I

1997 • 97 citations

Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II.

1996 • 91 citations

The multifunctional TFIIH complex and transcriptional control

1994 • 88 citations

Phosphorylation of the carboxy-terminal repeat domain in RNA polymerase II by cyclin-dependent kinases is sufficient to inhibit transcription

1997 • 81 citations

RNA polymerases IIA and IIO have distinct roles during transcription from the TATA-less murine dihydrofolate reductase promoter.

1993 • 81 citations

Identification and characterization of a predominant isoform of human MKK3

1997 • 60 citations

Another chapter in the long history of endotoxin

1987 • 53 citations

The role of tyrosine kinases and map kinases in LPS-induced signaling.

1998 • 53 citations

Protein kinases from Aspergillus nidulans that phosphorylate the carboxyl-terminal domain of the largest subunit of RNA polymerase II.

1992 • 26 citations

Partial Truncation of the Yeast RNA Polymerase II Carboxyl-terminal Domain Preferentially Reduces Expression of Glycolytic Genes

1995 • 16 citations