Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

1985 • 1,817 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

The pathology and nomenclature of Hodgkin's disease.

1972 • 762 citations

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

1996 • 749 citations

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

1985 • 712 citations

Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.

1994 • 691 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

The human immunoglobulin VH repertoire

1995 • 469 citations

Somatic hypermutation in normal and transformed human B cells

1998 • 351 citations

Origin of Nodular Lymphocyte-Predominant Hodgkin's Disease from a Clonal Expansion of Highly Mutated Germinal-Center B Cells

1997 • 335 citations

High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells

1996 • 328 citations

Hodgkin and Reed–Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

1997 • 276 citations

Frequent Expression of the B-Cell–Specific Activator Protein in Reed-Sternberg Cells of Classical Hodgkin’s Disease Provides Further Evidence for Its B-Cell Origin

1999 • 204 citations

Hodgkin's Disease with Monoclonal and Polyclonal Populations of Reed–Sternberg Cells

1995 • 200 citations

Reed-Sternberg and Hodgkin Cells in Lymphocyte-Predominant Hodgkin’s Disease of Nodular Subtype Contain J Chain

1986 • 184 citations

Clonality in Nodular Lymphocyte-Predominant Hodgkin's Disease

1997 • 157 citations

Hodgkin's disease, lymphocyte predominance type, nodular--further evidence for a B cell derivation. L & H variants of Reed-Sternberg cells express L26, a pan B cell marker.

1988 • 156 citations

Classical Hodgkin's Disease and Follicular Lymphoma Originating From the Same Germinal Center B Cell

1999 • 134 citations

Hodgkin's disease with a B-cell phenotype often shows a VDJ rearrangement and somatic mutations in the VH genes

1994 • 120 citations

Lymphotoxin, tumour necrosis factor and interleukin‐6 gene transcripts are present in Hodgkin and Reed‐Sternberg cells of most Hodgkin's disease cases

1993 • 105 citations

Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.

1995 • 103 citations

L and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light-chain restriction.

1991 • 84 citations

Detection of immunoglobulin heavy‐chain gene rearrangement at the single‐cell level in malignant lymphomas: No rearrangement is found in hodgkin and reed‐sternberg cells

1994 • 76 citations

The expression of the B‐cell marker mb‐1 (CD79a) in Hodgkin's disease

1994 • 63 citations

Oct2 Transactivation from a Remote Enhancer Position Requires a B-Cell-Restricted Activity

1992 • 63 citations

Somatic Mutations Within the Untranslated Regions of Rearranged Ig Genes in a Case of Classical Hodgkin’s Disease as a Potential Cause for the Absence of Ig in the Lymphoma Cells

1999 • 51 citations

Demonstration of light chain mRNA in Hodgkin's disease

1993 • 48 citations

Phenotype, genotype and clonality of Reed‐Sternberg cells in nodular sclerosis Hodgkin’s disease: results of a single‐cell study

1996 • 40 citations

Lymphocyte predominance Hodgkin's disease. Evidence for a kappa light chain-restricted monotypic B-cell neoplasm.

1995 • 39 citations

Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity.

1992 • 32 citations

Correlation Between Presence of Clonal Rearrangements of Immunoglobulin Heavy Chain Genes and B-Cell Antigen Expression in Hodgkin’s Disease

1995 • 30 citations

IgH AND TcR-γ GENE REARRANGEMENTS IDENTIFIED IN HODGKIN'S DISEASE BY PCR DEMONSTRATE LACK OF CORRELATION BETWEEN GENOTYPE, PHENOTYPE, AND EPSTEIN-BARRVIRUS STATUS

1997 • 26 citations

Poor correlation between clonal immunoglobulin gene rearrangement and immunoglobulin gene transcription in Hodgkin's disease.

1996 • 23 citations

Evaluation of clonal immunoglobulin heavy chain rearrangements in Hodgkin's disease using the polymerase chain reaction (PCR)

1995 • 23 citations

Efficient transcription of an immunoglobulin kappa promoter requires specific sequence elements overlapping with and downstream of the transcriptional start site

1997 • 16 citations

Combination of Hodgkin's disease and diffuse large cell lymphoma: an in situ hybridization study for immunoglobulin light chain messenger RNA

1995 • 14 citations

Extinction of immunoglobulin gene expression in B cells upon fusion with HeLa cells is preceded by rapid nuclear depletion of essential transcription factors and is accompanied by widespread inactivation of genes expressed in a B cell-specific manner

1997 • 12 citations

Hodgkin's disease: immunoglobulin heavy and light chain gene rearrangements revealed in single Hodgkin/Reed-Sternberg cells

1999 • 10 citations

Coordinate suppression of myeloma-specific genes and expression of fibroblast-specific genes in myeloma X fibroblast somatic cell hybrids

1996 • 9 citations

Detection of immunoglobulin light chain mRNA in nodular sclerosing Hodgkin's disease by in situ hybridization with biotinylated oligonucleotide probes compared with immunohistochemical staining with poly‐ and monoclonal antibodies

1992 • 8 citations

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