Origin of Nodular Lymphocyte-Predominant Hodgkin's Disease from a Clonal Expansion of Highly Mutated Germinal-Center B Cells

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

1994 • 6,495 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

The pathology and nomenclature of Hodgkin's disease.

1972 • 762 citations

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

1996 • 749 citations

Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.

1994 • 691 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

The human immunoglobulin VH repertoire

1995 • 469 citations

Improved PCR method for detecting monoclonal immunoglobulin heavy chain rearrangement in B cell neoplasms.

1992 • 268 citations

Hodgkin's Disease: A clinicopathologic study of 659 cases

1982 • 228 citations

Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family‐specific oligonucleotide probes

1991 • 215 citations

Hodgkin's Disease with Monoclonal and Polyclonal Populations of Reed–Sternberg Cells

1995 • 200 citations

Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle

1994 • 187 citations

Reed-Sternberg and Hodgkin Cells in Lymphocyte-Predominant Hodgkin’s Disease of Nodular Subtype Contain J Chain

1986 • 184 citations

Hodgkin's disease, lymphocyte predominance type, nodular--further evidence for a B cell derivation. L & H variants of Reed-Sternberg cells express L26, a pan B cell marker.

1988 • 156 citations

Nodular and Diffuse Types of Lymphocyte Predominance Hodgkin's Disease

1988 • 140 citations

Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease

1996 • 138 citations

Hodgkin's disease with a B-cell phenotype often shows a VDJ rearrangement and somatic mutations in the VH genes

1994 • 120 citations

Lymphocyte predominance Hodgkin's disease: lineage and clonality determination using a single-cell assay

1994 • 117 citations

Lymphocyte predominant Hodgkin's disease nodular subtype with coexistent "large cell lymphoma". Histological progression or composite malignancy?

1988 • 113 citations

Lymphotoxin, tumour necrosis factor and interleukin‐6 gene transcripts are present in Hodgkin and Reed‐Sternberg cells of most Hodgkin's disease cases

1993 • 105 citations

Progressive Transformation of Germinal Centers With and Without Association to Hodgkin's Disease

1990 • 100 citations

Clonal relationship between lymphocytic predominance Hodgkin's disease and concurrent or subsequent large-cell lymphoma of B lineage

1995 • 92 citations

L and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light-chain restriction.

1991 • 84 citations

Hodgkin's Disease

1944 • 77 citations

Nodular lymphocyte-predominant Hodgkin's disease associated with large- cell lymphoma: analysis of Ig gene rearrangements by V-J polymerase chain reaction

1996 • 77 citations

Detection of immunoglobulin heavy‐chain gene rearrangement at the single‐cell level in malignant lymphomas: No rearrangement is found in hodgkin and reed‐sternberg cells

1994 • 76 citations

The expression of the B‐cell marker mb‐1 (CD79a) in Hodgkin's disease

1994 • 63 citations

Lymphocyte predominance Hodgkin's disease. Evidence for a kappa light chain-restricted monotypic B-cell neoplasm.

1995 • 39 citations

Paraffin section markers for reed-sternberg cells. A comparative study of peanut agglutinin, leu-m1, ln-2, and ber-h2

1989 • 30 citations

Nodular lymphocyte predominance Hodgkin's disease: a monoclonal or polyclonal B-cell disorder?

1996 • 29 citations

Detection of immunoglobulin heavy chain gene rearrangements in Hodgkin's disease using PCR.

1993 • 23 citations

Analysis of antigen receptor genes in Hodgkin's disease.

1993 • 17 citations

Combination of Hodgkin's disease and diffuse large cell lymphoma: an in situ hybridization study for immunoglobulin light chain messenger RNA

1995 • 14 citations