Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons

Free radicals in biology and medicine

1991 • 17,840 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

Toxicity of iron and hydrogen peroxide: the Fenton reaction

1995 • 1,232 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1993 • 857 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

1995 • 779 citations

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1993 • 740 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

1994 • 571 citations

Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+.

1985 • 489 citations

Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide

1991 • 487 citations

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

2000 • 422 citations

Protection against tissue damage in vivo by desferrioxamine: What is its mechanism of action?

1989 • 385 citations

Involvement of Free Radicals in Excitotoxicity In Vivo

1995 • 325 citations

Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21^waf1/cip1, and Erythropoietin

1999 • 319 citations

Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals

1999 • 270 citations

Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose

1993 • 265 citations

Excitotoxicity, free radicals, and cell membrane changes

1994 • 228 citations

α-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia

1994 • 224 citations

Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats.

1994 • 207 citations

Brain Injury after Perinatal Hypoxia-Ischemia Is Exacerbated in Copper/Zinc Superoxide Dismutase Transgenic Mice

1996 • 193 citations

Protection against oxidative damage to CNS by α-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers

1991 • 183 citations

Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia

1998 • 183 citations

Iron, Transferrin, and Ferritin in the Rat Brain During Development and Aging

1994 • 179 citations

Acidosis Potentiates Oxidative Neuronal Death by Multiple Mechanisms

1999 • 163 citations

Reactions of ferrioxamine and desferrioxamine with the hydroxyl radical

1982 • 151 citations

Superoxide dismutase, glutathione peroxidase and catalase in developing rat brain

1982 • 147 citations

Molecular and biochemical mechanisms of perinatal brain injury

2001 • 139 citations

Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat

1999 • 138 citations

Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons

1992 • 121 citations

Regional Differences in Late-Onset Iron Deposition, Ferritin, Transferrin, Astrocyte Proliferation, and Microglial Activation after Transient Forebrain Ischemia in Rat Brain

1995 • 107 citations

Reduced neurotoxicity in transgenic mice overexpressing human copper-zinc-superoxide dismutase.

1990 • 103 citations

Antioxidant treatment protects striatal neurons against excitotoxic insults

1996 • 91 citations

Maze learning and motor activity deficits in adult mice induced by iron exposure during a critical postnatal period

2000 • 89 citations

Depletion of Intracellular Zinc Induces Protein Synthesis-Dependent Neuronal Apoptosis in Mouse Cortical Culture

1998 • 88 citations

The neuroprotective effect of deferoxamine in the hypoxic-ischemic immature mouse brain

2000 • 77 citations

Hydrogen peroxide-induced DNA damage is independent of nuclear calcium but dependent on redox-active ions

1998 • 76 citations

Increasing vulnerability of astrocytes to oxidative injury with age despite constant antioxidant defenses

1997 • 70 citations

Diverse effects of metal chelating agents on the neuronal cytotoxicity of zinc in the hippocampus

1998 • 63 citations

Alpha-Phenyl-N-Tert-Butylnitrone Attenuates Excitotoxicity in Rat Striatum by Preventing Hydroxyl Radical Accumulation

1997 • 57 citations

Hydrogen peroxide is selectively toxic to immature murine neurons in vitro

1997 • 51 citations

Iron supplementation aggravates periventricular cystic white matter lesions in newborn mice

1998 • 39 citations

3-Nitropropionic acid: an astrocyte-sparing neurotoxin in vitro

1999 • 39 citations

Effect of metal chelating agents on the direct and seizure-related neuronal death induced by zinc and kainic acid

1998 • 37 citations

Micromolar Zinc Affects Endonucleolytic Activity in Hydrogen Peroxide-Mediated Apoptosis

1998 • 35 citations

Gamma and Pulse Radiolysis Investigation of the Reaction of Desferrioxamine with Superoxide Anions

1989 • 11 citations

Zn²⁺ Blocks the NMDA- and Ca²⁺-Triggered Postexposure Current I _pe in Hippocampal Pyramidal Cells

1998 • 11 citations