Increasing vulnerability of astrocytes to oxidative injury with age despite constant antioxidant defenses

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

Measurement of catalase activity in tissue extracts

1970 • 1,183 citations

Biologically relevant metal ion‐dependent hydroxyl radical generation An update

1992 • 862 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.

1991 • 591 citations

Free radicals in cerebral ischemia.

1978 • 589 citations

Free Radicals and Brain Damage

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The regional distribution and cellular localization of iron in the rat brain

1984 • 487 citations

Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains

1990 • 457 citations

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

1992 • 450 citations

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

1989 • 414 citations

Vitamin E, Ascorbate, Glutathione, Glutathicne Disulfide, and Enzymes of Glutathione Metabolism in Cultures of Chick Astrocytes and Neurons: Evidence that Astrocytes Play an Important Role in Antioxidative Processes in the Brain

1994 • 413 citations

Astrocytes, ependymal cells, and oligodendrocytes develop on schedule in dissociated cell cultures of embryonic rat brain

1981 • 351 citations

Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury

1987 • 334 citations

A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: Its use in the simultaneous fluorimetric assay of cellular activation processes

1984 • 322 citations

CARBOHYDRATE AND ENERGY METABOLISM IN PERINATAL RAT BRAIN: RELATION TO SURVIVAL IN ANOXIA

1975 • 311 citations

Lipid Peroxidation In Vivo Induced by Reversible Global Ischemia in Rat Brain

1984 • 283 citations

TOLERANCE OF THE NEWBORN TO ANOXIA

1941 • 281 citations

On Iron Metabolism and Its Regulation

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21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures

1990 • 248 citations

Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity

1995 • 226 citations

The use of monochlorobimane to determine hepatic GSH levels and synthesis

1990 • 214 citations

Some effects of copper deficiency on leucocyte function in sheep and cattle

1981 • 186 citations

GFA Content, Glutamate Uptake and Activity of Glutamate Metabolizing Enzymes in Differentiating Mouse Astrocytes in Primary Cultures

1978 • 173 citations

Potentiation of lipid peroxides by ischemia in rat brain

1982 • 171 citations

Superoxide dismutase, glutathione peroxidase and catalase in developing rat brain

1982 • 147 citations

Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats.

1992 • 146 citations

Topographical and cytological localization of iron in rat and monkey brains

1981 • 142 citations

Astrocytes, brain aging, and neurodegeneration

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Nonidentical distribution of transferrin and ferric iron in human brain

1988 • 127 citations

Altered cellular distribution of iron in the central nervous system of myelin deficient rats

1990 • 126 citations

The survival of young rats in nitrogen

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Oral stereotypy induced by amphetamine microinjection into striatum: An anatomical mapping study

1994 • 116 citations

Vulnerability to glucose deprivation injury correlates with glutathione levels in astrocytes

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Chemiluminescence in hypoxic brain--the second report: cerebral protective effect of mannitol, vitamin E and glucocorticoid.

1985 • 98 citations

Suppression of hydroperoxide-induced cytotoxicity by polyphenols.

1994 • 94 citations

Age‐Related Regional Changes in Hydroxyl Radical Stress and Antioxidants in Gerbil Brain

1993 • 93 citations

Flow cytometric measurement of lipid peroxidation in vital cells using parinaric acid

1992 • 91 citations

Recovery of Postischemic Brain Metabolism and Function Following Treatment with a Free Radical Scavenger and Platelet‐Activating Factor Antagonists

1991 • 83 citations

Regional Cerebral Glucose Utilization in the Immature Rat: Effect of Hypoxia-Ischemia

1989 • 79 citations

Superoxide dismutase and glutathione peroxidase activities in rat brain.

1978 • 79 citations

Pharmacological protection of reoxygenation damage to in vitro brain slice tissue

1985 • 78 citations

Brain glucose metabolism in the newborn rat

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Lectin staining of cultured CNS microglia.

1992 • 72 citations

Ischemia/reperfusion-induced changes in membrane proteins and lipids of gerbil cortical synaptosomes

1995 • 72 citations

Iron histochemistry of the substantia nigra in Parkinson's disease.

1994 • 66 citations

Iron metabolism and its regulation. A review.

1995 • 64 citations

Regulation of the Glial Fibrillary Acidic Protein (GFAP) and of its Encoding mRNA in the Developing Brain and in Cultured Astrocytes

1990 • 59 citations

Glutathione‐S‐Transferase Activity in the Brain: Species, Sex, Regional, and Age Differences

1981 • 58 citations

Correlation between content of high-energy phosphates and hypoxic-ischemic damage in immature and mature astrocytes

1994 • 54 citations

Hydrogen peroxide cytotoxicity in cultured cardiac myocytes is iron dependent

1994 • 52 citations

Trolox attenuates cortical neuronal injury induced by iron, ultraviolet light, glucose deprivation, or AMPA

1994 • 52 citations

Age Dependence of the Level of the Enzymes Involved in the Protection against Active Oxygen Species in the Rat Brain

1987 • 48 citations

Extracellular iron chelators protect kidney cells from hypoxia/reoxygenation

1994 • 47 citations

Effects of deprivation of oxygen and glucose on the neural activity and the level of high energy phosphates in the hippocampal slices of immature and adult rat

1989 • 46 citations

Chemiluminescence in hypoxic brain--the second report: cerebral protective effect of mannitol, vitamin E and glucocorticoid.

1985 • 44 citations

Attenuation of Glutamate-induced Neuronal Swelling and Toxicity in Transgenic Mice Overexpressing Human CuZn-Superoxide Dismutase

1990 • 43 citations

Age-related changes of oxygen free radical production in the rat brain slice after hypoxia: on-line measurement using enhanced chemiluminescence

1995 • 40 citations

Characterisation of oxidative injury to an intestinal cell line (HT-29) by hydrogen peroxide.

1994 • 39 citations

Free radical scavenging systems of rat astroglial cells in primary culture: Effects of anoxia and drug treatment

1992 • 37 citations

Differing response of the glutathione system to fasting in neonatal and adult guinea pigs

1992 • 25 citations

Astrocyte survival in the absence of exogenous substrate: Comparison of immature and mature cells

1995 • 23 citations

Transferrin, carbonic anhydrase C and ferritin in dissociated murine brain cell cultures

1988 • 23 citations

Dual effect of deferoxamine on free radical formation and reoxygenation injury in isolated hepatocytes

1995 • 22 citations

Failure of Iron Chelators to Protect Against Cerebral Infarction in Hypoxia-Ischemia

1993 • 12 citations