Hydrogen peroxide-induced DNA damage is independent of nuclear calcium but dependent on redox-active ions

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Biologically relevant metal ion‐dependent hydroxyl radical generation An update

1992 • 862 citations

Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+.

1985 • 489 citations

Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide

1991 • 487 citations

Subcellular Calcium Transients Visualized by Confocal Microscopy in a Voltage-Clamped Vertebrate Neuron

1990 • 341 citations

DNA precipitation assay: A rapid and simple method for detecting DNA damage in mammalian cells

1988 • 323 citations

[2] Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection

1994 • 303 citations

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.

1989 • 284 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

Hydroxyl Radical Formation from Cuprous Ion and Hydrogen Peroxide: A Spin-Trapping Study

1995 • 182 citations

Regional Changes in Calcium Underlying Contraction of Single Smooth Muscle Cells

1987 • 179 citations

Calcium chelator Quin 2 prevents hydrogen‐peroxide‐induced DNA breakage and cytotoxicity

1989 • 157 citations

Hydrogen peroxide activates agonist-sensitive Ca2+-flux pathways in canine venous endothelial cells

1994 • 142 citations

Measurement of oxidized and methylated DNA bases by HPLC with electrochemical detection

1996 • 141 citations

Direct evidence for inhibition of free radical formation from Cu(I) and hydrogen peroxide by glutathione and other potential ligands using the EPR spin-trapping technique

1992 • 134 citations

Active oxygen induced DNA strand breakage and poly ADP-ribosylation in promotable and non-promotable JB6 mouse epidermal cells

1988 • 119 citations

Research communication copper-1,10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells, resulting from direct oxidation by the hydroxyl radical

1996 • 107 citations

Superoxide anion increases intracellular pH, intracellular free calcium, and arachidonate release in human amnion cells

1991 • 106 citations

Differential Regulation of Nuclear and Cytosolic Ca2+ in HeLa Cells

1996 • 106 citations

1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions

1996 • 101 citations

Stimulated rise in neuronal calcium is faster and greater in the nucleus than the cytosol

1991 • 97 citations

Intracellular calcium mobilization by inositol 1,4,5-trisphosphate: intracellular movements and compartmentalization

1993 • 95 citations

Purification of All Forms of HeLa Cell Mitochondrial DNA and Assessment of Damage to It Caused by Hydrogen Peroxide Treatment of Mitochondria or Cells

1995 • 94 citations

Oxidative DNA Damage in Human Respiratory Tract Epithelial Cells. Time Course in Relation to DNA Strand Breakage

1996 • 86 citations

Nuclear targeting of aequorin

1994 • 79 citations

DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells

1995 • 58 citations

Binding of Iron and Inhibition of Iron-Dependent Oxidative Cell Injury by the “Calcium Chelator” 1,2-Bis(2-Aminophenoxy)Ethane N,N,N′,N′-tetraacetic Acid (BAPTA)

1998 • 35 citations

DNA strand breakage during physiological apoptosis of the embryonic chick lens: Free 3' OH end single strand breaks do not accumulate even in the presence of a cation‐independent deoxyribonuclease

1994 • 31 citations

Parallel changes in nuclear and cytosolic calcium in mouse pancreatic β-cells

1997 • 27 citations

Separate analysis of nuclear and cytosolic Ca2+ concentrations in human umbilical vein endothelial cells

1996 • 27 citations

Differential protective effects of O‐phenanthroline and catalase on H₂O₂‐induced DNA damage and inhibition of protein synthesis in endothelial cells

1991 • 25 citations

Thapsigargin-induced nuclear calcium signals in rat basophilic leukaemia cells

1994 • 19 citations

Calcium Indicator Dye Quin2 Inhibits Hydrogen Peroxide-Induced DNA Strand Break Formation via Chelation of Iron

1994 • 16 citations