Specific Deficiency in Nuclear Factor-κB Activation in Neurons of the Central Nervous System

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

Control of apoptosis by Rel/NF-κB transcription factors

1999 • 1,204 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

NF-kB: a crucial transcription factor for glial and neuronal cell function

1997 • 1,005 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling

2000 • 927 citations

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

1999 • 827 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

NF-κB is activated and promotes cell death in focal cerebral ischemia

1999 • 648 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons

1999 • 552 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

Roles of Nuclear Factor κB in Neuronal Survival and Plasticity

2000 • 465 citations

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

1996 • 414 citations

Synergy between Interferon-γ and Tumor Necrosis Factor-α in Transcriptional Activation Is Mediated by Cooperation between Signal Transducer and Activator of Transcription 1 and Nuclear Factor κB

1997 • 410 citations

Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm

1997 • 405 citations

Constitutive NF-kB Activity in Neurons

1994 • 400 citations

Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis

1995 • 392 citations

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

1997 • 364 citations

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.

1996 • 352 citations

NF-κB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-κB-Inducing Kinase and IκB Kinase

2000 • 347 citations

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

1996 • 326 citations

Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors.

1992 • 297 citations

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.

1994 • 296 citations

Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.

1994 • 288 citations

Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis

1999 • 280 citations

The pro‐ or anti‐apoptotic function of NF‐κB is determined by the nature of the apoptotic stimulus

2000 • 250 citations

Protein Synthesis Inhibitors Reveal Differential Regulation of Mitogen-Activated Protein Kinase and Stress-Activated Protein Kinase Pathways That Converge on Elk-1

1995 • 243 citations

Role of the TRAF Binding Site and NF-κB Activation in Epstein-Barr Virus Latent Membrane Protein 1-Induced Cell Gene Expression

1998 • 229 citations

Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages.

1991 • 226 citations

Brain synapses contain inducible forms of the transcription factor NF-κB

1993 • 225 citations

Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation

2000 • 202 citations

Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.

1993 • 189 citations

Nuclear factor-κB/Rel proteins

1999 • 180 citations

Anisomycin Selectively Desensitizes Signalling Components Involved in Stress Kinase Activation and fos and jun Induction

1998 • 178 citations

NFκB Mediates Apoptosis through Transcriptional Activation of Fas (CD95) in Adenoviral Hepatitis

2000 • 165 citations

Act1, an NF-κB-activating protein

2000 • 164 citations

IL-1-induced NFκB and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)

2001 • 161 citations

Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB.

1999 • 157 citations

CIKS, a connection to IκB kinase and stress-activated protein kinase

2000 • 153 citations

Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-κ B-like nuclear protein

1992 • 147 citations

Differential Regulation and Function of Fas Expression on Glial Cells

2000 • 132 citations

Reduced Incidence and Severity of Antigen-induced Autoimmune Diseases in Mice Lacking Interferon Regulatory Factor-1

1997 • 131 citations

Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

1999 • 123 citations

Fas/Apo [Apoptosis]-1 and Associated Proteins in the Differentiating Cerebral Cortex: Induction of Caspase-Dependent Cell Death and Activation of NF-κB

1999 • 120 citations

Tumor Necrosis Factor (TNF) Receptor 1 Signaling Downstream of TNF Receptor-associated Factor 2

1997 • 117 citations

A Pathway of Neuronal Apoptosis Induced by Hypoxia/Reoxygenation

2000 • 116 citations

Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo.

1995 • 115 citations

Possible role of NF-κB and p53 in the glutamate-induced pro-apoptotic neuronal pathway

1999 • 109 citations

Wnt-1 dependent activation of the survival factor NF-?B in PC12 cells

2000 • 101 citations

Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli

1997 • 99 citations

Regulation of MHC class I and beta 2-microglobulin gene expression in human neuronal cells. Factor binding to conserved cis-acting regulatory sequences correlates with expression of the genes.

1993 • 99 citations

Cell type‐specific regulation of major histocompatibility complex (MHC) Class I gene expression in astrocytes, oligodendrocytes, and neurons

1993 • 94 citations

Structure and Regulation of the Human Interferon Regulatory Factor 1 (IRF-1) and IRF-2 Genes: Implications for a Gene Network in the Interferon System

1994 • 91 citations

Proteolytic Processing of NF- κB/I κB in Human Monocytes

1995 • 88 citations

Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages

1995 • 88 citations

Regulation of FasL by NF-κB and AP-1 in Fas-dependent Thymineless Death of Human Colon Carcinoma Cells

2000 • 85 citations

Developmental and tissue-specific expression of nuclear proteins that bind the regulatory element of the major histocompatibility complex class I gene.

1989 • 84 citations

Superinduction of NF-κB by Actinomycin D and Cycloheximide in Epithelial Cells

1996 • 83 citations

Identification and Characterization of Nuclear Factor κB Binding Sites in the Murine bcl‐χ Promoter

2000 • 74 citations

Increased Inducible Activation of NF-κB and Responsive Genes in Astrocytes Deficient in the Protein Tyrosine Phosphatase SHP-1

1998 • 72 citations

Differences between GABA Receptor Binding to Membranes from Cerebellum during Postnatal Development and from Cultured Cerebellar Granule Cells

1982 • 72 citations

Transcription factor NF-κB: friend or foe of neurons?

1998 • 69 citations

Interleukin‐1β Uses Common and Distinct Signaling Pathways for Induction of the Interleukin‐6 and Tumor Necrosis Factor α Genes in the Human Astrocytoma Cell Line U373

1996 • 68 citations

Induction of IP-10 chemokine promoter by measles virus: comparison with interferon-γ shows the use of the same response element but with differential DNA–protein binding profiles

1997 • 57 citations

The NF-κB Signaling Pathway Is Not Required for Fas Ligand Gene Induction but Mediates Protection from Activation-induced Cell Death

2000 • 55 citations

Kainate receptors activate NF-κB via MAP kinase in striatal neurones

2000 • 47 citations

Failure of measles virus to activate nuclear factor-kappa B in neuronal cells: implications on the immune response to viral infections in the central nervous system.

1999 • 41 citations

DNA damage-induced apoptosis and Ice gene induction in mitogenically activated T lymphocytes require IRF-1.

1997 • 36 citations

Nuclear factor kappa B-mediated kainate neurotoxicity in the rat and hamster hippocampus

1999 • 32 citations

Neuron-specific regulation of major histocompatibility complex class I, interferon-β, and anti-viral state genes

1995 • 30 citations

Failure of Measles Virus to Activate Nuclear Factor-κB in Neuronal Cells: Implications on the Immune Response to Viral Infections in the Central Nervous System

1999 • 28 citations

Identification of a Novel Cytokine Response Element in the Human IFN Regulatory Factor-1 Gene Promoter

2000 • 27 citations

Attenuation of nitric oxide synthase induction in IRF-1-deficient glial cells

1997 • 25 citations

Two factors, IRF1 and KBF1/NF-kappa B, cooperate during induction of MHC class I gene expression by interferon alpha beta or Newcastle disease virus.

1993 • 24 citations

A mechanism for selective induction of 2′-5′ oligoadenylate synthetase, anti-viral state, but not MHC Class I genes by interferon-beta in neurons

1999 • 21 citations

Interferon Regulatory Factor Element and Interferon Regulatory Factor 1 in the Induction of Major Histocompatibility Complex Class I Genes in Neural Cells

1995 • 19 citations

Protein Synthesis Inhibitors Cycloheximide and Anisomycin Induce Interleukin-6 Gene Expression and Activate Transcription Factor NF-κB

1997 • 16 citations

Expression of major histocompatibility complex (MHC) class I genes in astrocytes correlates with the presence of nuclear factors that bind to constitutive and inducible enahcers

1992 • 15 citations