The tax protein-DNA interaction is essential for HTLV-I transactivation in Vitro

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex

1992 • 964 citations

Nonintercalating DNA-binding ligands: Specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material

1986 • 765 citations

Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

1997 • 714 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

Recognition of the four Watson–Crick base pairs in the DNA minor groove by synthetic ligands

1998 • 498 citations

Regulation of gene expression by small molecules

1997 • 465 citations

Recognition of DNA by designed ligands at subnanomolar concentrations

1996 • 391 citations

Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids

1996 • 357 citations

A Transcriptional Activator Protein Encoded by the x- lor Region of the Human T-Cell Leukemia Virus

1985 • 346 citations

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP

1996 • 344 citations

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction.

1992 • 318 citations

HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization

1993 • 312 citations

A Structural Basis for Recognition of A·T and T·A Base Pairs in the Minor Groove of B-DNA

1998 • 304 citations

Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat

1987 • 251 citations

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands

1998 • 218 citations

Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence

1988 • 218 citations

Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation

1985 • 215 citations

Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription.

1986 • 212 citations

A transcriptional enhancer sequence of HTLV-I is responsible for trans-activation mediated by p40 chi HTLV-I.

1986 • 190 citations

Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer.

1991 • 188 citations

Anchoring of CREB Binding Protein to the Human T-Cell Leukemia Virus Type 1 Promoter: a Molecular Mechanism of Tax Transactivation

1997 • 179 citations

Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer.

1986 • 175 citations

An Exposed KID-Like Domain in Human T-Cell Lymphotropic Virus Type 1 Tax Is Responsible for the Recruitment of Coactivators CBP/p300

1998 • 174 citations

Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB).

1993 • 161 citations

The x Gene Is Essential for HTLV Replication

1985 • 161 citations

Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax

1995 • 150 citations

HTLV-1-associated diseases.

1997 • 144 citations

Solution structure of the chromomycin-DNA complex

1989 • 138 citations

Aliphatic/Aromatic Amino Acid Pairings for Polyamide Recognition in the Minor Groove of DNA

1998 • 138 citations

Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax

1995 • 131 citations

Location of cis-acting regulatory sequences in the human T-cell leukemia virus type I long terminal repeat.

1985 • 127 citations

A unique enhancer element for the trans activator (p40tax) of human T-cell leukemia virus type I that is distinct from cyclic AMP- and 12-O-tetradecanoylphorbol-13-acetate-responsive elements

1989 • 122 citations

Human T-Cell Leukemia Virus Type 1 Tax Requires Direct Access to DNA for Recruitment of CREB Binding Protein to the Viral Promoter

1998 • 120 citations

Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: implications for viral gene expression.

1988 • 107 citations

In vitro selection of DNA elements highly responsive to the human T-cell lymphotropic virus type I transcriptional activator, Tax.

1994 • 105 citations

Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I tax and CREB

1995 • 101 citations

Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB.

1994 • 97 citations

Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat

1996 • 96 citations

Complex Formation between CREB and Tax Enhances the Binding Affinity of CREB for the Human T-Cell Leukemia Virus Type 1 21-Base-Pair Repeats

1996 • 83 citations

A Molecular Mechanism for Human T-cell Leukemia Virus Latency and Tax Transactivation

1995 • 81 citations

Tax1 induction of the HTLV-I 21 bp enhancer requires cooperation between two cellular DNA-binding proteins.

1990 • 74 citations

HTLV-I Tax self-association in optimal trans-activation function

1997 • 73 citations

Direct interaction of CREB protein with 21 bp Tax-response elements of HTLV-ILTR.

1992 • 69 citations

Quantitative studies of the effect of HTLV-I Tax protein on CREB protein - DNA binding

1994 • 68 citations

The Human T-cell Leukemia Virus-1 Transcriptional Activator Tax Enhances cAMP-responsive Element-binding Protein (CREB) Binding Activity through Interactions with the DNA Minor Groove

1998 • 68 citations

The Coactivator CBP Stimulates Human T-cell Lymphotrophic Virus Type I Tax Transactivation in Vitro

1998 • 67 citations

Specific Regions of Contact between Human T-cell Leukemia Virus Type I Tax Protein and DNA Identified by Photocross-linking

1998 • 62 citations

Human T-cell leukemia virus types I and II exhibit different DNase I protection patterns

1988 • 57 citations

DNase I Footprinting as an Assay for Mammalian Gene Regulatory Proteins

1987 • 53 citations

Molecular interactions between the coactivator CBP and the human T-cell leukemia virus tax protein

1998 • 52 citations

Chimeric proteins composed of Jun and CREB define domains required for interaction with the human T-cell leukemia virus type 1 Tax protein

1995 • 44 citations

Isolation and characterization of the tax protein of HTLV-I.

1989 • 26 citations

Synergism between two distinct elements of the HTLV-I enhancer during activation by the trans-activator of HTLV-I.

1991 • 24 citations

Targeting of the HIV-1 long terminal repeat with chromomycin potentiates the inhibitory effects of a triplex-forming oligonucleotide on Sp1–DNA interactions and in vitro transcription

1997 • 23 citations

An Extended α-Helix and Specific Amino Acid Residues Opposite the DNA-binding Surface of the cAMP Response Element Binding Protein Basic Domain Are Important for Human T Cell Lymphotropic Retrovirus Type I Tax Binding

1998 • 19 citations

In vitro transcription of human T-cell leukemia virus type 1 is RNA polymerase II dependent

1997 • 9 citations