Recognition of DNA by designed ligands at subnanomolar concentrations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

1978 • 2,092 citations

Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding

1990 • 508 citations

Zinc Finger Phage: Affinity Selection of Fingers with New DNA-Binding Specificities

1994 • 417 citations

Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR.

1989 • 389 citations

[9] Quantitative DNase footprint titration: A method for studying protein-DNA interactions

1986 • 357 citations

Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids

1996 • 357 citations

Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage.

1994 • 321 citations

Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions.

1994 • 284 citations

Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence

1989 • 243 citations

Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins.

1993 • 227 citations

Toward rules relating zinc finger protein sequences and DNA binding site preferences.

1992 • 223 citations

Design of peptides that bind in the minor groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' sequences by a dimeric side-by-side motif

1992 • 219 citations

Binding modes of distamycin A with d(CGCAAATTTGCG)2 determined by two-dimensional NMR

1990 • 218 citations

In vitro selection of zinc fingers with altered DNA-binding specificity

1994 • 215 citations

DNA structural variations produced by actinomycin and distamycin as revealed by DNAase I footprinting

1984 • 205 citations

Design of a G⋅C-Specific DNA Minor Groove-Binding Peptide

1994 • 190 citations

Hairpin Peptide Motif. A New Class of Oligopeptides for Sequence-Specific Recognition in the Minor Groove of Double-Helical DNA

1994 • 187 citations

Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin.

1992 • 183 citations

Adenine specific DNA chemical sequencing reaction

1987 • 118 citations

Enhanced sequence specific recognition in the minor groove of DNA by covalent peptide dimers: bis(pyridine-2-carboxamidonetropsin)(CH2)3-6

1993 • 86 citations

Binding affinities of synthetic peptides, pyridine-2-carboxamidonetropsin and 1-methylimidazole-2-carboxamidonetropsin, that form 2:1 complexes in the minor groove of double-helical DNA

1993 • 85 citations

Antiparallel side-by-side heterodimer for sequence-specific recognition in the minor groove of DNA by a distamycin/1-methylimidazole-2-carboxamide-netropsin pair

1993 • 81 citations

NMR characterization of a heterocomplex formed by distamycin (Dst) and its analog 2-imidazole-distamycin (2 ImD) with d(CGCAAGTTGGC):d(GCCAACTTGCG): preference for the 1:1:1 2-ImD:Dst:DNA complex over the 2:1 2-ImD:DNA and the 2:1 Dst:DNA complexes

1993 • 68 citations

Recognition in the Minor Groove of DNA at 5'-(A,T)GCGC(A,T)-3' by a Four Ring Tripeptide Dimer. Reversal of the Specificity of the Natural Product Distamycin

1995 • 60 citations

Design of a Covalent Peptide Heterodimer for Sequence-Specific Recognition in the Minor Groove of Double-Helical DNA

1994 • 59 citations

Structural and Dynamic Characterization of the Heterodimeric and Homodimeric Complexes of Distamycin and 1-Methylimidazole-2-carboxamide-netropsin Bound to the Minor Groove of DNA

1994 • 59 citations

Cyclic polyamides for recognition in the minor groove of DNA.

1995 • 52 citations

A New DNA Minor Groove Binding Motif: Cross-Linked Lexitropsins

1994 • 50 citations

Structural analysis of covalent peptide dimers, bis(pyridine-2-carboxamidonetropsin)(CH2)3-6, in complex with 5'-TGACT-3' sites by two-dimensional NMR

1993 • 47 citations