Superhelical stress and nucleosome-mediated repression of 5S RNA gene transcription in vitro.

A new method for sequencing DNA.

1977 • 7,941 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

Supercoiling of the DNA template during transcription.

1987 • 1,909 citations

Structure of the nucleosome core particle at 7 Å resolution

1984 • 1,028 citations

DNA Topoisomerases

1981 • 977 citations

Determination of the number of superhelical turns in simian virus 40 DNA by gel electrophoresis.

1975 • 538 citations

Nucleotide sequences in Xenopus 5S DNA required for transcription termination

1981 • 515 citations

Chromatin reconstituted from tandemly repeated cloned DNA fragments and core histones: A model system for study of higher order structure

1985 • 469 citations

Chromatin assembly in Xenopus oocytes: In vivo studies

1984 • 404 citations

The organization of histones and DNA in chromatin: Evidence for an arginine-rich histone kernel

1976 • 371 citations

Assembly of newly replicated chromatin

1978 • 360 citations

The structure of DNA in a nucleosome.

1990 • 353 citations

Stable transcription complexes of Xenopus 5S RNA genes: A means to maintain the differentiated state

1982 • 352 citations

Artificial nucleosome positioning sequences.

1989 • 347 citations

A new procedure for purifying histone pairs H2A+H2B and H3+H4 from chromatin using hydroxylapatite

1979 • 327 citations

A nuclear extract of xenopus laevis oocytes that accurately transcribes 5S RNA genes

1978 • 323 citations

The transcriptional regulation of Xenopus 5S RNA genes in chromatin: The roles of active stable transcription complexes and histone H1

1984 • 265 citations

Histone contributions to the structure of DNA in the nucleosome.

1991 • 256 citations

Structural analysis of a triple complex between the histone octamer, a Xenopus gene for 5S RNA and transcription factor IIIA.

1985 • 222 citations

Formation of a rate-limiting intermediate in 5S RNA gene transcription

1985 • 213 citations

Dominant and specific repression of Xenopus oocyte 5S RNA genes and satellite I DNA by histone H1.

1989 • 188 citations

A bacteriophage RNA polymerase transcribes through a Xenopus 5S RNA gene transcription complex without disrupting it

1986 • 169 citations

Formation and stability of the 5 S RNA transcription complex.

1985 • 156 citations

A bacteriophage RNA polymerase transcribes in vitro through a nucleosome core without displacing it

1987 • 148 citations

Formation of nucleosomes on positively supercoiled DNA.

1991 • 133 citations

Competition between transcription complex assembly and chromatin assembly on replicating DNA.

1990 • 127 citations

Assembly of spaced chromatin involvement of ATP and DNA topoisomerase activity.

1988 • 125 citations

Rapid "footprinting" on supercoiled DNA.

1985 • 121 citations

Nucleosomes inhibit both transcriptional initiation and elongation by RNA polymerase III in vitro.

1989 • 115 citations

Characterization of the repressed 5S DNA minichromosomes assembled in vitro with a high-speed supernatant of Xenopus laevis oocytes.

1988 • 112 citations

Chromatin assembly on replicating DNAin vitro

1990 • 108 citations

The reactivation of developmentally inert 5S genes in somatic nuclei injected into Xenopus oocytes

1981 • 104 citations

Transcription complex disruption caused by a transition in chromatin structure.

1991 • 95 citations

Histone H1 represses transcription from minichromosomes assembled in vitro.

1989 • 92 citations

Novobiocin inhibition of simian virus 40 DNA replication

1980 • 85 citations

Preferential Association of Newly Synthesized H3 and H4 Histones with Newly Replicated DNA1

1978 • 77 citations

DNA gyrase can supercoil DNA circles as small as 174 base pairs.

1989 • 76 citations

Sedimentation of an RNA polymerase complex from vaccinia virus that specifically initiates and terminates transcription.

1987 • 75 citations

Structure of the two distinct types of minichromosomes that are assembled on DNA injected in Xenopus oocytes

1985 • 75 citations

The transcription complex of the 5 S RNA gene, but not transcription factor IIIA alone, prevents nucleosomal repression of transcription.

1990 • 59 citations

Novobiocin precipitates histones at concentrations normally used to inhibit eukaryotic type II topoisomerase

1986 • 58 citations

Tandemly repeated DNA sequences from Xenopus laevis

1983 • 58 citations

Multistep pathway for replication-dependent nucleosome assembly.

1989 • 53 citations

Transcription factor requirements for in vitro formation of transcriptionally competent 5S rRNA gene chromatin.

1990 • 51 citations

Effects of DNA supercoiling on the topological properties of nucleosomes.

1987 • 46 citations

Transcriptional activation ofXenopusclass III genes in chromatin isolated from sperm and somatic nuclei

1989 • 45 citations

Inhibition of transcription in eukaryotic cells by X-irradiation: relation to the loss of topological constraint in closed DNA loops

1988 • 44 citations

Novobiocin inhibits RNA polymerase III transcriptionin vitroby a mechanism distinct from DNA topoisomerase II

1986 • 39 citations

Novobiocin inhibits passive chromatin assembly in vitro.

1986 • 34 citations

The transcription complex of the Xenopus somatic 5 S RNA gene. A functional analysis of protein-DNA interactions outside of the internal control region.

1990 • 34 citations

Two TFIIIA activities regulate expression of the Xenopus 5S RNA gene families.

1989 • 34 citations

Characterization of the Repressed 5S DNA Minichromosomes Assembled In Vitro with a High-Speed Supernatant of Xenopus laevis Oocytes

1988 • 33 citations

Histone H1 Represses Transcription from Minichromosomes Assembled In Vitro

1989 • 33 citations

DNA supercoiling and eukaryotic gene expression.

1988 • 24 citations

Transcription Factor Requirements for In Vitro Formation of Transcriptionally Competent 5S rRNA Gene Chromatin

1990 • 18 citations