Biological significance of liver cell polyploidy: an hypothesis

The micronucleus test

1975 • 2,322 citations

Control of proliferation in animal cells

1974 • 1,177 citations

Stem Cell Concepts

1979 • 569 citations

Cell Polyploidy: Its Relation to Tissue Growth and Function

1977 • 394 citations

The formation and properties of macrophage polykaryons (inflammatory giant cells)

1974 • 285 citations

The DNA content of micronuclei induced in mouse bone marrow by γ-irradiation: evidence that micronuclei arise from acentric chromosomal fragments

1977 • 245 citations

Biological Mechanisms Underlying the Aging Process

1963 • 195 citations

The Growth of Liver Parenchymal Nuclei and Its Endocrine Regulation

1969 • 185 citations

A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo

1980 • 162 citations

Polyploïdie somatique dans le foie de rat: I. Le rôle des cellules binucléées dans la genèse des cellules polyploïdes

1966 • 160 citations

Chromosome aberrations and radiation-induced cell death

1973 • 156 citations

The fate of chromosome aberrations

1973 • 155 citations

The effect of ploidy on chemical mutagenesis in cultured chinese hamster cells

1973 • 139 citations

The occurrence and formation of binucleate and multinucleate cells and polyploid nuclei in the mouse liver

1948 • 138 citations

The origin of binucleate and large mono nucleate cells in the liver of the rat

1942 • 127 citations

G 2 Block in Chinese Hamster Cells Induced by X-Irradiation, Hyperthermia, Cycloheximide, or Actinomycin-D

1976 • 100 citations

Chromosome Aberrations in Liver Cells in Relation to the Somatic Mutation Theory of Aging

1963 • 74 citations

Endopolyploidy: Towards an understanding of its biological significance

1978 • 64 citations

Cell Cycle and Cell Differentiation

1975 • 55 citations

Comparative studies of DNA size in various tissues of mice during the aging process

1976 • 54 citations

Latent injury and repair in rat liver induced to regenerate at intervals after x-radiation.

1960 • 51 citations

Cell cycle and cell differentiation

1976 • 43 citations

Aging, Carcinogenesis, and Radiation Biology: The role of nucleic acid addition reactions

1977 • 41 citations

Genetic Factors in Aging

1971 • 39 citations

Correlation between species life span and capacity to activate 7,12-dimethylbenz(a)anthracene to a form mutagenic to a mammalian cell

1975 • 38 citations

The Elimination of Chromosome Aberrations in Liver Cells by Cell Division

1964 • 33 citations

Mutagenic, clastogenic and oncogenic effects of 1-β-d-arabinofuranosylcytosine

1979 • 28 citations

The longevity of diploid and polyploid human fibroblasts

1978 • 26 citations

Selection for temperature‐sensitive mutants of diploid and tetraploid mammalian cells

1974 • 24 citations

Effect of Aging on the Frequency of Metaphase Chromosome Aberrations in the Liver of the Chinese Hamster

1973 • 22 citations

Cells and Senescence

1978 • 22 citations

Increased levels of euploidy as a strategy against rapid ageing in diploid mammalian systems: An hypothesis

1977 • 22 citations

The Genetic Effects of Ionizing Radiations

1971 • 18 citations

Molecular Mechanism of Polyploidization and Binucleate Formation of the Hepatocyte

1977 • 18 citations

Hylid Frogs: Polyploid Classes of DNA in Liver Nuclei

1966 • 17 citations

Premature chromosome condensation following X irradiation of mammalian cells: expression time and dose-response.

1979 • 13 citations

Polyploidization in rat liver: the role of binucleate cells.

1976 • 13 citations

Premature Chromosome Condensation Following X Irradiation of Mammalian Cells: Expression Time and Dose-Response

1979 • 12 citations

Early appearance and mitotic activity of multinucleated giant cells in mice after combined injection of talc and prednisolone acetate. A model for studying rapid histiocytic polykarion formation in vivo.

1978 • 11 citations

Microdensitometric and autoradiographic comparison of the DNA contents of foetal and adult rat liver nuclei

1978 • 10 citations

Lethal mutation hypothesis for the mechanism of action of the cytostatic alkylating agents

1965 • 8 citations

Polyploidy and sensitivity to alkylating mutagens

1975 • 8 citations

Der Einflu� der ploidie auf die Strahlenreaktion von S�ugerzellen

1974 • 5 citations

Chromosome Aberrations during Normal Epithelial Proliferation

1968 • 3 citations

[Detection of physiological protective properties against ionizing radiations in autotetraploids of buckwheat].

1960 • 1 citations

DNA repair—cellular level

1977 • 1 citations