Hormone action during aging: Alterations and mechanisms

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Membrane Receptors

1974 • 636 citations

Mechanisms Regulating the Concentration and the Conformation of Progesterone Receptor(s) in the Uterus

1973 • 361 citations

Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase.

1975 • 265 citations

Reduced β-adrenergic receptor concentrations in ageing man

1977 • 258 citations

The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes.

1976 • 185 citations

Acetylcholine receptor metabolism in a nonfusing muscle cell line.

1977 • 160 citations

Effects of Age and Obesity on Insulin Binding to Isolated Adipocytes12¹²

1975 • 144 citations

Androgen receptor in rat liver: Hormonal and developmental regulation of the cytoplasmic receptor and its correlation with the androgen-dependent synthesis of α2u-globulin

1974 • 134 citations

Beta-Receptor Activity in Aorta

1970 • 133 citations

Recent developments in the age-related alteration of enzymes: A review

1977 • 120 citations

Independent Variation of Glucagon and Epinephrine Responsive Components of Hepatic Adenyl Cyclase as a Function of Age, Sex and Steroid Hormones

1970 • 119 citations

Properties of adenylate cyclase from senescent rat brain

1973 • 112 citations

The relationship between age and relaxation of vascular smooth muscle in the rabbit and rat.

1976 • 108 citations

Insulin receptor defect in insulin resistance: Studies in the obese-hyperglycemic mouse

1972 • 105 citations

Age-Related Changes in Specific Glucocorticoid Binding by Steroid-Responsive Tissues of Rats

1974 • 100 citations

Studies of glucagon resistance in large rat adipocytes: 125I-labeled glucagon binding and lipolytic capacity

1974 • 95 citations

Effect of aging on cyclic AMP levels and adenylate cyclase and phosphodiesterase activities in the rat corpus striatum

1977 • 91 citations

Age-related changes in isocitrate lyase from the free living nematode, Turbatrix aceti.

1975 • 85 citations

Effects of Age and Sex on³H-Cortisol Uptake, Binding and Metabolism in Liver and on Enzyme Induction Capacity

1971 • 75 citations

Decrease in 17β-oestradiol receptor in brain of ageing rats

1975 • 75 citations

Comparative Effects of Insulin on Adipose Tissue Segments and Isolated Fat Cells of Rat and Man*

1967 • 74 citations

Insulin Binding to Cultured Human Fibroblasts Increases with Normal and Precocious Aging

1976 • 67 citations

Age-dependent regulation of mammalian DNA synthesis and cell proliferation In vivo

1972 • 67 citations

Regulation of sensitivity to beta-adrenergic stimulation in induction of pineal N-acetyltransferase.

1975 • 66 citations

Aging in the rat prostate

1975 • 65 citations

Reductions in Glucocorticoid Inhibition of Glucose Oxidation and Presumptive Glucocorticoid Receptor Content in Rat Adipocytes During Aging

1976 • 62 citations

Alterations in atropine sites of the brain of rats as a function of age

1976 • 62 citations

Hormone-sensitive fat cell adenylate cyclase in the rat. Influences of growth, cell size, and aging.

1976 • 57 citations

Adrenergic β-receptor activity and cyclic AMP metabolism in vascular smooth muscle; variations with age

1975 • 56 citations

Age-related parallel decline in beta-adrenergic receptors, adenylate cyclase and phosphodiesterase activity in rat erythrocyte membranes

1977 • 56 citations

Selective loss of adipose cell responsiveness to glucagon with growth in the rat

1972 • 54 citations

Aging and Hormones

1974 • 53 citations

Age related changes in hormone binding by target cells and tissues; Possible role in altered adaptive responsiveness

1975 • 53 citations

Aging-associated diminished rat prostate androgen receptor content concurrent with decreased androgen dependence

1977 • 48 citations

Synthesis of acetylcholine receptor during differentiation of cultured embryonic muscle cells.

1975 • 47 citations

Impairments in availability of insulin to liver in vivo and in binding of insulin to purified hepatic plasma membrane during aging

1973 • 46 citations

Increase of glucagon receptors in hyperthyroidism

1976 • 46 citations

Reduced glucocorticoid binding site concentration in cortical neuronal perikarya from senescent rats

1976 • 45 citations

[3H] cortisol binding by young and old human liver cytosol proteins in vitro

1973 • 43 citations

Neuroendocrine mechanisms and aging.

1979 • 42 citations

Reduced glucocorticoid responsiveness and receptor concentration in splenic leukocytes of senescent rats

1975 • 37 citations

Effect of Age on Thyroxine-Induced Cardiac Hypertrophy in Mice

1973 • 34 citations

Epinephrine-and glucagon-sensitive adenylate cyclases of rat liver during aging

1977 • 34 citations

Estrogenic regulation of uterine carbohydrate metabolism during senescence

1969 • 34 citations

Induction of acetylcholinesterase by 17-β estradiol in the brain of rats of various ages

1973 • 26 citations

Changes in Hormone Binding and Responsiveness in Target Cells and Tissues During Aging

1975 • 26 citations

Phosphodiesterase and adenyl-cyclase activities in the cerebral cortex of the aging rat

1975 • 24 citations

Age-dependent changes in the adenylate cyclase and phosphodiesterase activity of rat erythrocytes

1973 • 23 citations

Possible Changes in Tissue Sensitivity in the Age-Dependent Stimulation of DNA Synthesis In Vivo

1973 • 22 citations

Effects of electrical stimulation and norepinephrine on cyclic-AMP levels in the cerebral cortex of the aging rat

1975 • 20 citations

Age-dependent regulation of mammalian DNA synthesis and cell division in vivo by glucocorticoids

1974 • 20 citations

Hepatic Glucocorticoid Binders in Mature and Senescent C57BL/6J Male Mice

1976 • 19 citations

Changes in cortisol binding to soluble receptor proteins in rat liver and thymus during development and ageing

1975 • 17 citations

The Metabolic Responsiveness of Young and Old Female Rats to Thyroxine

1969 • 15 citations

Age-related changes in glucocorticoid binding by rat splenic leukocytes: possible cause of altered adaptive responsiveness.

1975 • 14 citations

Altersabhängigkeit der Fettzellgrösse und der lipolytischen Aktivität im menschlichen Fettgewebe

1971 • 14 citations

Correlation between [³H] dexamethasone binding to a rat liver cytosol receptor protein and stimulation of RNA synthesis by glucocorticosteroids

1973 • 13 citations

Age-dependent regulation of isoproterenol-stimulated DNA synthesis in rat salivary gland in vivo

1974 • 12 citations

[Age dependence of fat cell size and lipolytic activity in human adipose tissue].

1971 • 12 citations

Alterations with age in the informational storage and flow systems of the mammalian cell.

1978 • 12 citations

Variations among individual mice in binding of growth hormone and insulin to membranes from animals of different ages

1976 • 11 citations

Regulation of isoproterenol-stimulated DNA synthesis in rat salivary gland in vivo by adrenal glucocorticoids

1974 • 10 citations

Hormone-sensitive lipolytic activity of the aorta of different age groups of rats

1972 • 10 citations

Age-related changes in glucocorticoid binding by rat splenic leukocytes: possible cause of altered adaptive responsiveness

1975 • 9 citations

Response to corticotrophin and correlation between excretion of creatinine and urinary steroids and between the clearance of creatinine and urinary steroids in ageing

1963 • 9 citations

Effect of age on the bonding of H3 testosterone with receptor protein from rat brain and testes.

1977 • 7 citations

Hormonal receptor and responsiveness changes during aging: genetic modulation.

1978 • 6 citations

Changes in Hormone Receptors During Aging: Role in Altered Hormonal Responsiveness

1979 • 1 citations