Cross-Linkage Hypothesis of Aging: DNA Adducts in Chromatin as a Primary Aging Process

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Evolution by gene duplication

1970 • 5,849 citations

Evolution at Two Levels in Humans and Chimpanzees

1975 • 2,796 citations

High resolution acrylamide gel electrophoresis of histones

1969 • 2,470 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Lipid peroxidation damage to cell components.

1973 • 925 citations

Repetitive and Non-Repetitive DNA Sequences and a Speculation on the Origins of Evolutionary Novelty

1971 • 797 citations

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1974 • 738 citations

Time, cells, and aging

1962 • 553 citations

Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids

1969 • 487 citations

VITAMIN E AND FREE RADICAL PEROXIDATION OF LIPIDS*

1972 • 471 citations

Ethane Evolution: A New Index of Lipid Peroxidation

1974 • 449 citations

Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde

1969 • 399 citations

FUNCTIONAL and STRUCTURAL ASPECTS OF BIOLOGICAL MEMBRANES: A SUGGESTED STRUCTURAL ROLE FOR VITAMIN E IN THE CONTROL OF MEMBRANE PERMEABILITY and STABILITY

1972 • 388 citations

Cross-Linking of Collagen

1973 • 384 citations

Mechanisms of chromosomal aberration production III. Chemicals and ionizing radiation

1974 • 363 citations

Biological significance of the intermolecular crosslinks of collagen

1974 • 346 citations

Free Radical Theory of Aging: Effect of Free Radical Reaction Inhibitors on the Mortality Rate of Male LAF1 Mice

1968 • 339 citations

Will antioxidant nutrients slow aging processes?

1968 • 279 citations

Lipid peroxidation: its measurement, occurrence, and significance in animal tissues.

1967 • 250 citations

Length of Life and Nutrition in the Rat

1961 • 236 citations

Effect of Antioxidants and Nutrients on Lipid Peroxidation Fluorescent Products and Aging Parameters in the Mouse

1973 • 224 citations

Role of Free Radicals in Mutation, Cancer, Aging, and the Maintenance of Life

1962 • 204 citations

Age-Associated Changes in the DNA of Mouse Tissue

1971 • 203 citations

Developmental Physiology and Aging.

1973 • 195 citations

Isolation of deoxyribonucleic acid from mammalian tissues

1967 • 192 citations

Evolution of human longevity and the genetic complexity governing aging rate.

1975 • 182 citations

Intrinsic Mutagenesis: A Genetic Approach to Ageing.

1975 • 177 citations

The 5-Methylcytosine in DNA of Rats

1973 • 177 citations

The thermal degradation of nucleic acids

1961 • 176 citations

Free Radicals in Biological Systems

1970 • 174 citations

The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents.

1973 • 167 citations

Hydridization of ribonucleic acid with unique sequences of mouse deoxyribonucleic acid

1972 • 166 citations

FREE-RADICAL LIPID PEROXIDATION DAMAGE AND ITS INHIBITION BY VITAMIN E AND SELENIUM.

1965 • 164 citations

Interaction of histone half-molecules with deoxyribonucleic acid

1971 • 162 citations

Free radical theory of aging: dietary implications

1972 • 152 citations

Principles of mammalian aging

1971 • 150 citations

PROLONGATION OF LIFE: ROLE OF FREE RADICAL REACTIONS IN AGING

1969 • 145 citations

The basis of free radical pathology.

1973 • 137 citations

Maturation and Longevity in Relation to Cranial Capacity in Hominid Evolution

1975 • 135 citations

ON THE HISTOCHEMISTRY AND ULTRASTRUCTURE OF AGE PIGMENT.

1964 • 133 citations

Free radical reactions and their importance in biochemical systems.

1973 • 129 citations

VITAMIN E AND THE BIOLOGICAL ANTIOXIDANT THEORY

1972 • 126 citations

Deficient DNA Repair in Human Progeroid Cells

1973 • 126 citations

Prolongation of the Normal Lifespan and Inhibition of Spontaneous Cancer by Antioxidants

1961 • 122 citations

Antioxidants, lipid peroxidation and chemical-induced liver injury.

1973 • 122 citations

Advances in gerontological research

1968 • 116 citations

Theoretical of Aspects of Aging

1974 • 109 citations

Effect of Antioxidants on Life-Span of C57BL Mice

1971 • 109 citations

On the Possibility That DNA Repair Is Related to Age in Non-Dividing Cells

1974 • 108 citations

MONGOLIAN IDIOCY (MONGOLISM) AND MATERNAL AGE

1954 • 106 citations

The ageing, growth and death of cells

1974 • 105 citations

Age-Related Changes in Specific Glucocorticoid Binding by Steroid-Responsive Tissues of Rats

1974 • 100 citations

Helix-coil transition in nucleoprotein-chromatin structure

1973 • 98 citations

Towards a theory of development

1975 • 97 citations

Extension of the Lifespan of Cultured Normal Human Diploid Cells by Vitamin E

1974 • 96 citations

Free Radical Theory of Aging: Effect of the Amount and Degree of Unsaturation of Dietary Fat on Mortality Rate

1971 • 93 citations

The Radiation-Induced Addition of Proteins and Other Molecules to Nucleic Acids

1976 • 88 citations

THE DEVELOPMENT OF SOMATIC MUTATIONS IN MICE WITH AGE

1963 • 88 citations

Studies on ageing in nematodes III. Electronmicroscopical studies on age-associated cellular damage

1972 • 85 citations

The aging of collagen.

1963 • 85 citations

Studies on ageing in nematodes IV. The effect of anti-oxidants on cellular damage and life span

1972 • 81 citations

Altered rate of DNA replication in ageing human fibroblast cultures

1974 • 80 citations

Specificity in the association of histones with deoxyribonucleic acid. Evidence from derivative thermal denaturation profiles

1971 • 79 citations

Increased Thermal Stability of Chromatin Containing 5-Bromodeoxyuridine-Substituted DNA

1974 • 78 citations

Human aging and disease

1963 • 78 citations

Histone acetylation during aging of human cells in culture

1972 • 74 citations

The ageing of connective tissue

1968 • 69 citations

Free Radical Pathology

1971 • 69 citations

Superoxide dismutase activity in WI-38 cell cultures: effects of age, trypsinization and SV-40 transformation.

1974 • 67 citations

Structural and Functional Changes in Nucleoprotein During the Ageing of the Cell

1970 • 62 citations

Structure studies on chromatin and nucleohistones. Thermal denaturation profiles recorded in the presence of urea

1971 • 61 citations

Photochemical addition of amino acids to thymine

1974 • 60 citations

Changes in the structure of rat liver DNA in relation to age

1972 • 57 citations

Comparison of doubling numbers attained by cultured animal cells with life span of species

1975 • 57 citations

Enzymatic RNA synthesis on irradiated DNA

1970 • 57 citations

Transcription of unique and reiterated DNA sequences in mouse liver and brain tissues as a function of age

1975 • 56 citations

Age related differences in the association of brain DNA and nuclear protein

1967 • 56 citations

Exogenous DNA polymerase-catalysed incorporation of deoxyribonucleotide monophosphates in nuclei of fixed mouse-brain cells *1Changes associated with age and X-irradiation

1971 • 55 citations

Regulation and deterioration of structure in membranes.

1967 • 55 citations

Age-Related Alterations in the Structure of DNA

1966 • 52 citations

Conformational Changes of Histones and DNA during the Thermal Denaturation of Nucleoprotein

1974 • 50 citations

Aging Increases Susceptibility of Mouse Skin to DMBA Carcinogenesis Independent of General Immune Status

1974 • 49 citations

Implications of aging research for society

1975 • 49 citations

Mechanics of chromatin template activation. Physical evidence for destabilization of nucleoproteins by polyanions.

1975 • 49 citations

Repairable and Irrepairable Damage in 5-bromouracil-substituted DNA Exposed to Ultra-violet Radiation

1971 • 48 citations

Age-Related Alterations in the Structure of DNA

1964 • 47 citations

The regulation of protein synthesis in the ageing cell

1970 • 47 citations

The position of aging studies

1974 • 47 citations

Age-associated studies on thermal stability and template effectiveness of DNA and nucleoproteins from beef thymus

1968 • 47 citations

The Stabilization of the Intermolecular Crosslinks of Collagen with Ageing

1969 • 45 citations

Age-related alterations in the structure of DNA. 3. Thermal stability of rat liver DNA, related to age, histone content and ionic strength.

1966 • 45 citations

AGING: PRESENT STATUS OF OUR CHEMICAL KNOWLEDGE

1962 • 45 citations

Reactivity of thymine to γ rays in HeLa chromatin and nucleoprotein preparations

1974 • 43 citations

Pathological implications of cell aging in vitro

1975 • 43 citations

DNA-to-protein Cross-linking in Synchronized HeLa Cells Exposed to Ultra-violet Light

1975 • 43 citations

A modified mouse liver chromatin preparation displaying age-related differences in salt dissociation and template ability

1972 • 43 citations

Preparation of some deoxyribonucleic acid–protein complexes from rat-liver homogenates

1958 • 42 citations

Histone-acetylating enzyme of brain

1970 • 41 citations

Redundancy of information content in the genome of mammalian species as a protective mechanism determining aging rate

1973 • 41 citations

Role of histones in the conformation of DNA in chromatin as studied by circular dichroism

1974 • 39 citations

Neurobiological aspects of maturation and aging

1976 • 36 citations

Chromosome Aberrations in Liver Cells of Guinea Pigs

1971 • 36 citations

Ultra-violet-light-induced DNA-to-protein Cross-linking in HeLa Cells

1970 • 35 citations

DNA Repair Processes in Mammals

2015 • 35 citations

Hybridizable ribonucleic acid of rat brain

1968 • 34 citations

The neuronal ceroid-lipofuscinoses--Batten-Vogt syndrome: a model for human aging?

1971 • 34 citations

Developmental and regional variations in ribonucleic acid synthesis on cerebral chromatin

1969 • 32 citations

Defective Proteins in Normal and Abnormal Human Fibroblasts during Aging in vitro1

2015 • 32 citations

Transcription on Irradiated DNA

1969 • 31 citations

Pharmacological control of aging

1970 • 31 citations

Chromosome Aberrations in Liver Cells of Dogs of Different Ages

1966 • 31 citations

The effect of X-irradiation on the priming ability of DNA in the RNA polymerase system

1964 • 30 citations

Age-Dependent Thermal Denaturation and Viscosity of Crude and Purified Desoxyribonucleic Acid Prepared from Bovine Thymus

1963 • 30 citations

Longevity of primates in captivity

1968 • 30 citations

A Model for Aging Based on Differential Repair of Somatic Mutational Damage

1974 • 29 citations

Oxidative Damage to Amino acids, peptides, and proteins by Radiation^a

1961 • 27 citations

Studies on ageing in nematodes III. Electronmicroscopical studies on age-associated cellular damage

1972 • 27 citations

Composition, template activity and thermostability of the liver chromatin in rats of various age

1972 • 27 citations

Aging: alteration of DNA-protein information.

1973 • 27 citations

The effects of γ-irradiation on the priming by deoxyribonucleohistone of ribonucleic acid polymerase

1967 • 27 citations

Effect of γ-Radiation on Deoxynucleoprotein acting as a Primer in RNA Synthesis

1964 • 26 citations

Messenger ribonucleic acid of cerebral nuclei

1967 • 25 citations

Aging: Alteration of DNA-Protein Information

1973 • 25 citations

Composition, template properties and thermostability of liver chromatin from rats of various age at deproteinization by NaCl solutions

1972 • 25 citations

Thymus Nucleoproteins. Thymus Histones in Young and Adult Rats

1970 • 23 citations

Effect of Aging on the Frequency of Metaphase Chromosome Aberrations in the Liver of the Chinese Hamster

1973 • 22 citations

NUCLEAR PROTEIN PATTERNS IN DEVELOPING AND ADULT BRAIN AND IN ETHYLNITROSOUREA‐INDUCED NEUROECTODERMAL TUMOURS OF THE RAT^1,2

1975 • 22 citations

Age-Related Alterations in the Structure of Nucleoprotein

1969 • 22 citations

Possible Changes in Tissue Sensitivity in the Age-Dependent Stimulation of DNA Synthesis In Vivo

1973 • 22 citations

Studies on the Histories and DNA of Calf and Old Cow Thymus

1968 • 20 citations

Age-related alterations in the structure of nucleoprotein. IV. Changes in the compoistion of whole histone from rat liver.

1969 • 20 citations

Compositional and transcriptional properties of chromatins isolated from cardiac muscle of young-mature and old dogs

1972 • 19 citations

Aging of the connective tissue: Collagen cross linking in animals of different species and equal age

1971 • 19 citations

Multiple peaks in the derivative melting curve of chromatin from animals of varying age

1974 • 18 citations

The template activity of rat liver chromatin

1969 • 18 citations

Young and old rats. ATP, alkaline phosphatase, cholesterol and protein levels in the blood; DNA and RNA contents of the river. Regulation by an aqueous thymus extract

1974 • 18 citations

Composition of Liver Histones in Aging Rat and Mouse

1975 • 17 citations

The effect of salt extraction and heat-denaturation on the behavior of rat liver chromatin

1968 • 17 citations

Vitamin E Decreases Erythrocyte Fragility after Whole-Body Irradiation

1975 • 16 citations

Investigations on amino acids bound to DNA

1967 • 15 citations

Aging life processes

1969 • 15 citations

Age-related changes in glucocorticoid binding by rat splenic leukocytes: possible cause of altered adaptive responsiveness.

1975 • 14 citations

Cellular activities during ageing in mammals

1969 • 14 citations

THE MUTATION THEORY OF AGING

1974 • 14 citations

Age-dependent changes in the structure and function of mammalian chromatin—I. Variations in chromatin template activity

1973 • 14 citations

Effect of Growth Conditions on Amino Acids Bound to Deoxyribonucleic Acid

1969 • 13 citations

Fluorescent Products from Irradiated Amino Acids and Proteins

1975 • 13 citations

Alterations in Deoxyribonucleic Acid-Bound Amino Acids With Age and Sex

1972 • 13 citations

Vitamin E and its role in cellular metabolism

1972 • 12 citations

Chromatin modification of chick embryo cells during in vitro senescence

1974 • 12 citations

The possible role of lipoperoxide in aging.

1970 • 12 citations

Age-Related Differences in Mouse Liver DNA Melting and Hydroxylapatite Fractionation

1970 • 11 citations

Amino acids associated with DNA of tumors.

1968 • 11 citations

Studies on a complex of deoxyribonucleic acid with non-histone protein

1966 • 10 citations

Chromosomal Aberrations in Liver Cells of Mice Fed Free Radical Reaction Inhibitors

1970 • 9 citations

Thermal Denaturation of DNA and Chromatin of Early and Late Passage Human Fibroblasts

1971 • 8 citations

Prevention of Malignant Change in Mammalian Cells During Prolonged Culture In Vitro

1974 • 7 citations

Enzymatic studies on the skeletal myosin A and actomyosin of aging rats

1975 • 7 citations

Covalent modification of nuclear proteins during aging

1975 • 6 citations

Macromolecular aging of collagen. I. Experiments in vivo and in vitro with different animal races.

1968 • 5 citations

Macromolecular Aging of Collagen. I.

1968 • 5 citations

Possible Mechanisms for Radiation Disturbance of Transcription

1974 • 4 citations

REDUCTION OF THE YIELD OF DNA IN THE DEPROTEINIZATION OF UV- OR $gamma$- IRRADIATED SOLUTIONS OF DEOXYRIBONUCLEOPROTEIN. I. DEPENDENCE OF THE MAGNITUDE OF THE EFFECT ON THE COMPLETENESS OF THE COMPLEXATION OF DNA WITH PROTEIN.

1970 • 4 citations

Alterations in cerebral protein-synthesizing systems during maturation

1973 • 3 citations

In vitro Studies of Transcription as a Function of Age in Mammalian Cells1

2015 • 2 citations

SOME PHYSICOCHEMICAL CHANGES IN DNA ISOLATED FROM THE ORGANS OF IRRADIATED RATS.

1969 • 2 citations