Testing the Commitment Theory of Cellular Aging

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

1963 • 2,742 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

1970 • 1,002 citations

THE MAINTENANCE OF THE ACCURACY OF PROTEIN SYNTHESIS AND ITS RELEVANCE TO AGEING

1963 • 950 citations

A simple cytochemical technique for demonstration of DNA in cells infected with mycoplasmas and viruses

1975 • 788 citations

Characteristics of a Human Diploid Cell Designated MRC-5

1970 • 593 citations

Altered Enzymes in Ageing Human Fibroblasts

1972 • 408 citations

Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia.

1974 • 304 citations

VARIATION IN THE LIFE-SPAN OF CLONES DERIVED FROM HUMAN DIPLOID CELL STRAINS

1974 • 272 citations

The maintenance of the accuracy of protein synthesis and its relevance to ageing: a correction.

1970 • 201 citations

ANEUPLOIDY IN THE DEGENERATIVE PHASE OF SERIAL CULTIVATION OF HUMAN CELL STRAINS

1963 • 193 citations

THE FATE OF SERIALLY TRANSPLANTED BONE MARROW CELL POPULATIONS FROM YOUNG AND OLD DONORS

1976 • 145 citations

Error Theory and Ageing in Human Diploid Fibroblasts

1972 • 135 citations

Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts.

1976 • 132 citations

DNA repair in late-passage human cells

1976 • 117 citations

Premature ageing and occurrance of altered enzyme in Werner's syndrome fibroblasts

1974 • 100 citations

Commitment to senescence: A model for the finite and infinite growth of diploid and transformed human fibroblasts in culture

1975 • 96 citations

Altered rate of DNA replication in ageing human fibroblast cultures

1974 • 80 citations

Chromosome changes during the in vitro ageing of MRC-5 human fibroblasts

1975 • 77 citations

Age-dependent excision repair of damaged thymine from γ-irradiated DNA by isolated nuclei from human fibroblasts

1975 • 72 citations

Heat-Labile Enzymes in Skin Fibroblasts from Subjects with Progeria

1975 • 70 citations

A rapid rise in cell variants during the senescence of populations of human fibroblasts

1975 • 69 citations

Effect of temperature on the longevity of human fibroblasts in culture

1973 • 40 citations

Defective Proteins in Normal and Abnormal Human Fibroblasts during Aging in vitro1

2015 • 32 citations