Thymocyte Apoptosis by Glucocorticoids and cAMP

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action.

1985 • 816 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

The Immune-Hypothalamic-Pituitary-Adrenal Axis*

1989 • 671 citations

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

1988 • 600 citations

Dopaminergic and Ligand-Independent Activation of Steroid Hormone Receptors

1991 • 577 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Many Transcription Factors Interact Synergistically with Steroid Receptors

1988 • 517 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis

1993 • 428 citations

Synergistic action of the glucocorticoid receptor with transcription factors.

1988 • 407 citations

MINIREVIEW: Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors

1990 • 394 citations

Thymus and Adrenals in the Response of the Organism to Injuries and Intoxications

1936 • 387 citations

The thymus selects the useful, neglects the useless and destroys the harmful

1989 • 378 citations

Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor

1988 • 370 citations

Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation

1990 • 365 citations

Steroid production in the thymus: implications for thymocyte selection.

1994 • 351 citations

Possible underlying mechanisms of sexual dimorphism in the immune response, fact and hypothesis

1989 • 346 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

1990 • 319 citations

Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution, and regulation by glucocorticoids, cyclic AMP, and phorbol ester.

1988 • 318 citations

Glucocorticoid hormone action

1976 • 318 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids.

1993 • 306 citations

Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression

1991 • 303 citations

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B.

1991 • 301 citations

Cytokines as modulators of the hypothalamus-pituitary-adrenal axis

1991 • 289 citations

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

1993 • 286 citations

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

1990 • 265 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

Phosphorylation of Steroid Hormone Receptors*

1992 • 243 citations

Transcriptional control by nuclear receptors

1991 • 234 citations

Control of transcription activation by steroid hormone receptors

1992 • 218 citations

Identification of phosphorylated sites in the mouse glucocorticoid receptor.

1991 • 208 citations

Location of cAMP-Dependent Protein Kinase Type I with the TCR-CD3 Complex

1994 • 200 citations

Rescue of thymocytes and T cell hybridomas from glucocorticoid‐induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire

1991 • 199 citations

HORMONE RESPONSE DOMAINS IN GENE TRANSCRIPTION

1992 • 185 citations

Multiple kinases and signal transduction. Phosphorylation of the T cell antigen receptor complex.

1987 • 168 citations

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression.

1986 • 166 citations

Glucocorticoid-mediated control of the activation and clonal deletion of peripheral T cells in vivo.

1993 • 163 citations

Modulation of glucocorticoid receptor function by protein kinase A.

1992 • 162 citations

The Purified Activated Glucocorticoid Receptor is a Homodimer

1989 • 156 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

1992 • 149 citations

Delivery and Transport of Glucocorticoids to Target Cells

1979 • 140 citations

bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation.

1993 • 140 citations

The mechanism of cAMP-induced Glucocorticoid Receptor Expression

1989 • 138 citations

Cyclic AMP concentrations modulate both calcium flux and hydrolysis of phosphatidylinositol phosphates in mouse T lymphocytes.

1988 • 129 citations

Latent agonist activity of the steroid antagonist, RU486, is unmasked in cells treated with activators of protein kinase A.

1993 • 109 citations

Modulation of cell signaling pathways can enhance or impair glucocorticoid-induced gene expression without altering the state of receptor phosphorylation.

1993 • 105 citations

Cyclic AMP-dependent protein kinase promotes glucocorticoid receptor function.

1986 • 97 citations

Site-directed mutagenesis of the phosphorylation sites in the mouse glucocorticoid receptor.

1993 • 96 citations

Isolation and Characterization of Glucocorticoid- and Cyclic AMP-Induced Genes in T Lymphocytes

1989 • 95 citations

Mode of entry of steroid and thyroid hormones into cells

1981 • 90 citations

The Transport of Steroids into Animal Cells in Culture

1981 • 89 citations

Synergistic action of glucocorticoid and estradiol responsive elements.

1988 • 79 citations

Killing of immature CD4⁺CD8⁺ thymocytes in vivo by anti‐CD3 or 5′‐(N‐ethyl)‐carboxamido‐adenosine is blocked by glucocorticoid receptor antagonist RU‐486

1993 • 79 citations

Thymocyte apoptosis a model of programmed cell death

1992 • 76 citations

Modulation of glucocorticoid receptor function by protein kinase A

1992 • 74 citations

Steroid hormone action

1993 • 69 citations

Evidence of synergy between Thy-1 and CD3/TCR complex in signal delivery to murine thymocytes for cell death.

1991 • 69 citations

DNA fragmentation in S49 lymphoma cells killed with glucocorticoids and other agents

1983 • 66 citations

Effects of okadaic acid, a protein phosphatase inhibitor, on glucocorticoid receptor-mediated enhancement.

1992 • 64 citations

Modulation of glucocorticoid receptor activity by cyclic nucleotides and its implications on the regulation of human skin fibroblast growth and protein synthesis

1984 • 62 citations

Proenkephalin Gene Expression in C6 Rat Glioma Cells: Potentiation of Cyclic Adenosine 3′,5′- Monophosphate-Dependent Transcription by Glucocorticoids

1991 • 61 citations

Latent agonist activity of the steroid antagonist, RU486, is unmasked in cells treated with activators of protein kinase A

1993 • 61 citations

Cyclic AMP potentiates glucocorticoid‐induced endogenous endonuclease activation in thymocytes ¹

1993 • 59 citations

cAMP analogs prevent activation-induced apoptosis of T cell hybridomas.

1993 • 56 citations

Modulation of thymocyte apoptosis by isoproterenol and prostaglandin E2

1991 • 54 citations

Developmental regulation of bcl-2 expression in the thymus.

1994 • 51 citations

Mutual cross-interference between glucocorticoid receptor and CREB inhibits transactivation in placental cells.

1992 • 48 citations

nti glucocorticoid receptor transcripts lack sequences encoding the amino-terminal transcriptional modulatory domain.

1990 • 47 citations

Apoptosis: Breaking the ICE

1994 • 46 citations

Regulation of Vasopressin Messenger RNA Levels in the Small Cell Lung Carcinoma Cell Line GLC-8: Interactions between Glucocorticoids and Second Messengers

1991 • 43 citations

Effect of Two Steroid Compounds on Weight of Thymus of Adrenalectomized Rats.

1940 • 41 citations

Immature thymocytes become sensitive to calcium-mediated apoptosis with the onset of CD8, CD4, and the T cell receptor expression: a role for bcl-2?

1993 • 34 citations

Stimulation of T-cells with OKT3 antibodies increases forskolin binding and cyclic AMP accumulation

1990 • 31 citations

Tumour necrosis factor-α enhances cAMP-induced programmed cell death in mouse thymocytes

1993 • 29 citations

Glucocorticoid-recognizing and -effector sites in rat liver plasma membrane. Kinetics of corticosterone uptake by isolated membrane vesicles—I. Binding and transport

1992 • 23 citations

Effects of okadaic acid, a protein phosphatase inhibitor, on glucocorticoid receptor-mediated enhancement

1992 • 20 citations

It is easier for a camel to pass the needle's eye

1992 • 20 citations

Activation of protein kinase C via the T-cell receptor complex potentiates cyclic AMP responses in T-cells

1989 • 18 citations

CD3-dependent increase in cyclic AMP in human T-cells following stimulation of the CD2 receptor

1991 • 14 citations

A trophoblast-specific factor(s) suppresses circulating prolactin levels and increases tyrosine hydroxylase activity in tuberoinfundibular dopaminergic neurons

1992 • 11 citations

Uptake of corticosterone into isolated rat liver cells: Possible involvement of Na+/K+-ATPase

1991 • 10 citations

Role of heat-shock proteins in steroid receptor function

1993 • 8 citations

Europeans to design chips for everything?

1989 • 1 citations