Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The Phosphoinositide 3-Kinase Pathway

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NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

The immunopathogenesis of sepsis

2002 • 2,686 citations

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2003 • 2,027 citations

Proinflammatory Cytokines

2000 • 1,857 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

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Molecular cloning and expression of glycogen synthase kinase-3/factor A.

1990 • 1,329 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

PKB/Akt

2001 • 1,066 citations

TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

2002 • 802 citations

The Phosphatidylinositol 3-Kinase-Akt Pathway Limits Lipopolysaccharide Activation of Signaling Pathways and Expression of Inflammatory Mediators in Human Monocytic Cells

2002 • 787 citations

GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins

2003 • 785 citations

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2001 • 693 citations

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2001 • 669 citations

Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

2000 • 663 citations

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

1995 • 537 citations

PI3K-mediated negative feedback regulation of IL-12 production in DCs

2002 • 534 citations

Lipopolysaccharides from Distinct Pathogens Induce Different Classes of Immune Responses In Vivo

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A Toll-Like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, via Induction of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and c-Fos in Dendritic Cells

2004 • 455 citations

Transcriptional Activation by NF-κB Requires Multiple Coactivators

1999 • 433 citations

Glycogen Synthase Kinase-3β Haploinsufficiency Mimics the Behavioral and Molecular Effects of Lithium

2004 • 415 citations

CREB DNA binding activity is inhibited by glycogen synthase kinase‐3β and facilitated by lithium

2001 • 410 citations

Phosphorylation of CREB at Ser-133 Induces Complex Formation with CREB-Binding Protein via a Direct Mechanism

1996 • 396 citations

The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense

2000 • 396 citations

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

2001 • 361 citations

Toll-Like Receptor 4, But Not Toll-Like Receptor 2, Is a Signaling Receptor forEscherichiaandSalmonellaLipopolysaccharides

2000 • 352 citations

Different Toll-like receptor agonists induce distinct macrophage responses

2001 • 349 citations

Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription.

1997 • 320 citations

Role of the Phosphatidylinositol 3 Kinase-Akt Pathway in the Regulation of IL-10 and IL-12 byPorphyromonas gingivalisLipopolysaccharide

2003 • 257 citations

Role of glycogen synthase kinase-3 in TNF-α-induced NF-κB activation and apoptosis in hepatocytes

2002 • 229 citations

IL-10 Released by Concomitant TLR2 Stimulation Blocks the Induction of a Subset of Th1 Cytokines That Are Specifically Induced by TLR4 or TLR3 in Human Dendritic Cells

2004 • 216 citations

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

2002 • 196 citations

Lipopolysaccharide Activates Akt in Human Alveolar Macrophages Resulting in Nuclear Accumulation and Transcriptional Activity of β-Catenin

2001 • 174 citations

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β

2003 • 173 citations

Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells

1999 • 161 citations

Glycogen Synthase Kinase-3β Regulates NF-κB1/p105 Stability

2003 • 156 citations

Toll-like Receptors 2 and 4 Activate STAT1 Serine Phosphorylation by Distinct Mechanisms in Macrophages

2003 • 109 citations

Gas6 Anti-apoptotic Signaling Requires NF-κB Activation

2001 • 104 citations

Toll-Like Receptor 4 and Toll-IL-1 Receptor Domain-Containing Adapter Protein (TIRAP)/Myeloid Differentiation Protein 88 Adapter-Like (Mal) Contribute to Maximal IL-6 Expression in Macrophages

2002 • 99 citations

Lithium Induces NF-κB Activation and Interleukin-8 Production in Human Intestinal Epithelial Cells

2002 • 56 citations