GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins

The PyMOL Molecular Graphics System

2002 • 18,218 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1995 • 5,246 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

GSK-3: tricks of the trade for a multi-tasking kinase

2003 • 2,027 citations

The renaissance of GSK3

2001 • 1,459 citations

The multifaceted roles of glycogen synthase kinase 3β in cellular signaling

2001 • 1,408 citations

The specificities of protein kinase inhibitors: an update

2003 • 1,345 citations

Normal Table of Xenopus Laevis.

1968 • 1,185 citations

GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

2003 • 1,145 citations

Chinese Drugs of Plant Origin

1992 • 992 citations

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

1997 • 908 citations

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

2001 • 865 citations

RIBBONS 2.0

1991 • 814 citations

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

1999 • 784 citations

Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

2001 • 685 citations

Crystal Structure of Glycogen Synthase Kinase 3β

2001 • 636 citations

Implementation of molecular replacement in AMoRe

2001 • 621 citations

Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.

1993 • 616 citations

New aspects of Wnt signaling pathways in higher vertebrates

2001 • 550 citations

Structural Insights and Biological Effects of Glycogen Synthase Kinase 3-specific Inhibitor AR-A014418

2003 • 504 citations

Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β

2003 • 481 citations

Human Wild-Type Tau Interacts with wingless Pathway Components and Produces Neurofibrillary Pathology in Drosophila

2002 • 474 citations

Cdk5 Is a Key Factor in Tau Aggregation and Tangle Formation In Vivo

2003 • 470 citations

Databases in Protein Crystallography

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Wnt Signaling Controls the Phosphorylation Status of β-Catenin

2002 • 464 citations

Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine

1992 • 454 citations

Glycogen synthase kinase 3: an emerging therapeutic target

2002 • 399 citations

Indirubin and Indigo Are Potent Aryl Hydrocarbon Receptor Ligands Present in Human Urine

2001 • 398 citations

Structure of GSK3beta reveals a primed phosphorylation mechanism.

2001 • 368 citations

Cyclic AMP Promotes Neuronal Survival by Phosphorylation of Glycogen Synthase Kinase 3β

2000 • 361 citations

Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25

2000 • 361 citations

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

2001 • 361 citations

Regulation and localization of tyrosine²¹⁶phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration

2000 • 359 citations

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

1997 • 351 citations

Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural development

1999 • 338 citations

Glycogen synthase kinase 3 (GSK‐3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation

2002 • 330 citations

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils

2003 • 321 citations

Glycogen Synthase Kinase-3β Facilitates Staurosporine- and Heat Shock-induced Apoptosis

2000 • 305 citations

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex

2003 • 303 citations

Structural Characterization of the GSK-3β Active Site Using Selective and Non-selective ATP-mimetic Inhibitors

2003 • 289 citations

Oxidation of Indole by Cytochrome P450 Enzymes

2000 • 289 citations

Indirubin and Meisoindigo in the Treatment of Chronic Myelogenous Leukemia in China

2002 • 274 citations

Structure and Regulation of the CDK5-p25nck5a Complex

2001 • 270 citations

Central Role of Glycogen Synthase Kinase-3β in Endoplasmic Reticulum Stress-induced Caspase-3 Activation

2002 • 258 citations

Glycogen synthase kinase‐3β, mood stabilizers, and neuroprotection

2002 • 241 citations

Further evidence that the inhibition of glycogen synthase kinase‐3β by IGF‐1 is mediated by PDK1/PKB‐induced phosphorylation of Ser‐9 and not by dephosphorylation of Tyr‐216

1997 • 232 citations

Expression and isolation of antimicrobial small molecules from soil DNA libraries.

2001 • 215 citations

Tyrian Purple: 6,6’-Dibromoindigo and Related Compounds

2001 • 214 citations

The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm

1996 • 211 citations

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc–induced apoptosis

2002 • 210 citations

Proapoptotic Stimuli Induce Nuclear Accumulation of Glycogen Synthase Kinase-3β

2001 • 209 citations

The GSK3β signaling cascade and neurodegenerative disease

2002 • 195 citations

Glycogen Synthase Kinase-3β Inhibitors Prevent Cellular Polyglutamine Toxicity Caused by the Huntington’s Disease Mutation

2002 • 187 citations

Glycogen Synthase Kinase-3β Activity Is Critical for Neuronal Death Caused by Inhibiting Phosphatidylinositol 3-Kinase or Akt but Not for Death Caused by Nerve Growth Factor Withdrawal

2000 • 182 citations

Identification of an indigo precursor from leaves of Isatis tinctoria (Woad)

2001 • 167 citations

Siamois is required for formation of Spemann’s organizer

1997 • 144 citations

Inhibitor Binding to Active and Inactive CDK2

2001 • 138 citations

TCF Is the Nuclear Effector of the β-Catenin Signal That Patterns the Sea Urchin Animal–Vegetal Axis

2000 • 137 citations

Intracellular Targets of Paullones

2002 • 136 citations

A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis

1997 • 134 citations

Über den Farbstoff des antiken Purpurs aus murex brandaris

1909 • 124 citations

Fibroblast Growth Factor 1 Regulates Signaling via the Glycogen Synthase Kinase-3β Pathway

2002 • 120 citations

GSK‐3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β‐catenin stabilisation without elevation of glycogen synthase activity

2001 • 87 citations

GSK3β Signalling: Casting a Wide Net in Alzheimer’s Disease

2002 • 85 citations

Wnt signaling involvement in β-amyloid-dependent neurodegeneration

2002 • 76 citations

Recruitment of Dioxin Receptor to Active Transcription Sites

2002 • 70 citations

Intra-M Phase-promoting Factor Phosphorylation of Cyclin B at the Prophase/Metaphase Transition

1999 • 67 citations

Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs?

2002 • 51 citations

Wnt signal transduction: kinase cogs in a nano-machine?

2002 • 49 citations

Biological Precursors and Genesis of Tyrian‐Purple

1971 • 47 citations

Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3′-phosphoadenosine-5′-phosphate phosphatase activities: a novel target of lithium therapy

2002 • 42 citations

Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates

2002 • 25 citations

Alzheimers Disease: Targets For Drug Development

2002 • 11 citations

Deleted Work

1955 • 0 citations