Lithium Induces NF-κB Activation and Interleukin-8 Production in Human Intestinal Epithelial Cells

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

Neural and developmental actions of lithium: A unifying hypothesis

1989 • 1,005 citations

Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors

2000 • 754 citations

Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.

1999 • 719 citations

Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide

2001 • 672 citations

Kinetic Properties of the Plasma Membrane Na+ -H+ Exchanger

1985 • 670 citations

Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity

1999 • 616 citations

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

1997 • 576 citations

Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice.

1996 • 517 citations

Molecular Targets of Lithium Action

2001 • 507 citations

Adenosine inhibits IL‐12 and TNF‐α production via adenosine A_2areceptor‐dependent and independent mechanisms

2000 • 488 citations

Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex

1988 • 474 citations

NF-κB as a Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules**This article was accepted for publication on 27 September 1996.

1997 • 472 citations

Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells.

1997 • 410 citations

The IκB/NF-κB system: a key determinant of mucosal inflammation and protection

2000 • 377 citations

Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock

2000 • 316 citations

Molecular Cloning and Characterization of a Novel (Na+,K+)/H+ Exchanger Localized to the trans-Golgi Network

2001 • 242 citations

Lithium and brain signal transduction systems

1994 • 200 citations

Lithium Increases Transcription Factor Binding to AP‐1 and Cyclic AMP‐Responsive Element in Cultured Neurons and Rat Brain

1997 • 178 citations

Structure/function studies of mammalian Na‐H exchangers‐‐an update.

1995 • 162 citations

Cytokine profiles of cultured microvascular endothelial cells from the human intestine

1998 • 160 citations

Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells.

1993 • 138 citations

Role of Toll-like receptors in inflammatory response in macrophages

2001 • 106 citations

Na+/H+ Antiport: Modulation by Atp and Role in Cell Volume Regulation

1994 • 106 citations

Wnt-1 dependent activation of the survival factor NF-?B in PC12 cells

2000 • 101 citations

Role of Na⁺/H⁺Exchange by Interferon-γ in Enhanced Expression of JE and I-A_βGenes

1989 • 83 citations

Transepithelial resistance can be regulated by the intestinal brush-border Na⁺/H⁺ exchanger NHE3

2000 • 78 citations

In vitro immunoregulatory effects of lithium in healthy volunteers

1999 • 72 citations

Lithium Activates the c‐Jun NH₂‐Terminal Kinases In Vitro and in the CNS In Vivo

1999 • 69 citations

Kinetic and Pharmacological Properties of Human Brain Na+/H+ Exchanger Isoform 5 Stably Expressed in Chinese Hamster Ovary Cells

2000 • 68 citations

The Recruitment of the Interleukin-1 (IL-1) Receptor-associated Kinase (IRAK) into Focal Adhesion Complexes Is Required for IL-1β-induced ERK Activation

2000 • 68 citations

Lithium Increases Tyrosine Hydroxylase Levels Both In Vivo and In Vitro

1998 • 64 citations

Biochemical events accompanying macrophage activation and the inhibition of colony‐stimulating factor‐1‐induced macrophage proliferation by tumor necrosis factor‐α, interferon‐γ, and lipopolysaccharide

1992 • 63 citations

Suppression of Human Alveolar Macrophage-derived Cytokines by Amiloride

1992 • 59 citations

The mammalian Na+/H+ antiporters NHE-1, NHE-2, and NHE-3 are electroneutral and voltage independent, but can couple to an H+ conductance.

1995 • 59 citations

Cellular Differentiation Causes a Selective Down-regulation of Interleukin (IL)-1β-mediated NF-κB Activation and IL-8 Gene Expression in Intestinal Epithelial Cells

2000 • 52 citations

Potentiation of Astroglial Nitric Oxide Synthase Type‐2 Expression by Lithium Chloride

1998 • 51 citations

Activation of Na-H exchange by intracellular lithium in barnacle muscle fibers

1992 • 46 citations

pH heterogeneity at intracellular and extracellular plasma membrane sites in HT29-C1 cell monolayers

2000 • 43 citations

Interactions of lithium and protons with the sodium-proton exchanger of dog red blood cells.

1986 • 37 citations

Polarised interleukin 8 secretion by HT 29/19A cells.

1994 • 36 citations

IL-1 activates the Na+/H+ antiport in a murine T cell.

1989 • 36 citations

Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation.

1993 • 34 citations

Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression

1991 • 30 citations

Cation Antiports of Animal Plasma Membranes

1994 • 30 citations

Inhibition of the Na+/H+ antiporter suppresses IL-12 p40 production by mouse macrophages

2001 • 30 citations

Modification of tumor necrosis factor-α (TNF-α) production by the Na+-dependent HCO3− cotransport in lipopolysaccharide-activated human monocytes

1995 • 27 citations

Toward a crystal-clear view of lithium's site of action.

1994 • 26 citations

Enhancement of Interleukin 2 Production in Human and Gibbon T Cells after In Vitro Treatment with Lithium

1991 • 25 citations

Lithium activates mammalian Na+/H+ exchangers: isoform specificity and inhibition by genistein

2000 • 23 citations

Synergistic induction of neurotensin gene transcription in PC12 cells parallels changes in AP-1 activity

1994 • 20 citations