Protein tyrosine phosphorylation and the adhesive functions of platelets

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Molecular mechanisms of platelet activation.

1989 • 903 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion

1989 • 490 citations

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

1990 • 480 citations

CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes

1989 • 474 citations

Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to “integrin”.

1987 • 466 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

1991 • 415 citations

Phosphorylation of the fibronectin receptor complex in cells transformed by oncogenes that encode tyrosine kinases.

1986 • 355 citations

Genetic analysis of a drosophila neural cell adhesion molecule: Interaction of fasciclin I and abelson tyrosine kinase mutations

1990 • 340 citations

Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

1986 • 329 citations

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

1990 • 328 citations

Thrombosis and haemostasis

1988 • 327 citations

Platelet Membrane Glycoproteins: Functions in Cellular Interactions

1990 • 298 citations

Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets

1991 • 289 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

1991 • 270 citations

Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate.

1989 • 260 citations

Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts.

1989 • 256 citations

Agrin induces phosphorylation of the nicotinic acetylcholine receptor

1991 • 253 citations

Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.

1989 • 250 citations

Role of thrombospondin in platelet aggregation.

1984 • 247 citations

Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins.

1990 • 237 citations

Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.

1988 • 229 citations

Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.

1986 • 229 citations

Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.

1990 • 204 citations

Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion.

1989 • 198 citations

Complex formation of platelet thrombospondin with fibrinogen.

1982 • 195 citations

Cellular adhesion: GPIIb-IIIa as a prototypic adhesion receptor.

1989 • 187 citations

The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering.

1987 • 186 citations

CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor

1990 • 174 citations

A platelet membrane glycoprotein (GP) deficiency in healthy blood donors: Naka- platelets lack detectable GPIV (CD36)

1990 • 166 citations

The role of cell-cell interaction in the development of the drosophila visual system

1990 • 163 citations

An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments]

1989 • 158 citations

Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets

1989 • 148 citations

Regulation of tyrosine phosphorylation of the nicotinic acetylcholine receptor at the rat neuromuscular lunction

1990 • 130 citations

Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets.

1990 • 126 citations

An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments]

1989 • 119 citations

Platelet-activating factor stimulation of tyrosine kinase and its relationship to phospholipase C in rabbit platelets: studies with genistein and monoclonal antibody to phosphotyrosine.

1990 • 101 citations

Monoclonal Antibodies Specific for a Conformationally Altered State of Fibrinogen

1990 • 87 citations

Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets [published erratum appears in J Cell Biol 1990 Mar;110(3):865]

1989 • 85 citations

Effects of OKM5, a monoclonal antibody to glycoprotein IV, on platelet aggregation and thrombospondin surface expression [see comments]

1990 • 83 citations

Vanadate and molybdate increase tyrosine phosphorylation in a 50-kilodalton protein and stimulate secretion in electropermeabilized platelets

1989 • 79 citations

Expression of cellular-yes protein in mammalian tissues.

1990 • 78 citations

Glycoprotein IIIa is phosphorylated in intact human platelets

1990 • 72 citations

Expression of p60fyn in human platelets.

1990 • 70 citations

Erbstatin blocks platelet activating factor‐induced protein‐tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets

1990 • 68 citations

Dynamic measurements of the platelet membrane glycoprotein IIb-IIIa receptor for fibrinogen by flow cytometry. I. Methodology, theory and results for two distinct activators

1991 • 58 citations

CD36-mediated signal transduction in human monocytes by anti-CD36 antibodies but not by anti-thrombospondin antibodies recognizing cell membrane-bound thrombospondin

1991 • 56 citations

Differential tyrosine-specific phosphorylation of integrin in Rous sarcoma virus transformed cells with differing transformed phenotypes.

1990 • 55 citations

Membrane interactions of pp60v-src: a model for myristylated tyrosine protein kinases.

1990 • 54 citations

Cellular partitioning of beta-1 integrins and their phosphorylated forms is altered after transformation by Rous sarcoma virus or treatment with cytochalasin D.

1991 • 42 citations

Identification of a new class of inducible receptors on platelets. Thrombospondin interacts with platelets via a GPIIb-IIIa-independent mechanism.

1986 • 41 citations

Divalent cation-dependent and independent surface expression of thrombospondin on thrombin-stimulated human platelets

1987 • 37 citations

Intracellular localization of pp60c-src in human platelets.

1990 • 33 citations

Elevation of cAMP, but not cGMP, inhibits thrombin-stimulated tyrosine phosphorylation in human platelets

1990 • 29 citations

GTP-binding proteins and platelet activation.

1991 • 28 citations

Phosphotyrosine phosphatase activity in human platelets

1991 • 26 citations

The production of phosphatidylinositol trisphosphate is stimulated by thrombin in human platelets

1991 • 16 citations

Tyrosine‐specific phosphorylation of gpIIIa in platelet membranes

1990 • 14 citations

Ca2(+)-sensitive binding of thrombospondin to U937 cells is due to the formation of calcium precipitate in the binding medium.

1991 • 14 citations

GTP-binding proteins and platelet activation.

1991 • 14 citations

Protein tyrosine phosphatases: a novel family of enzymes involved in transmembrane signalling.

1990 • 12 citations

Deleted Work

1955 • 0 citations