Erbstatin blocks platelet activating factor‐induced protein‐tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Physicochemical and Functional Identity of Rabbit Platelet-Activating Factor (PAF) Released in Vivo during IgE Anaphylaxis with PAF Released in Vitro from IgE Sensitized Basophils

1979 • 454 citations

Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

1986 • 329 citations

The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin.

1984 • 319 citations

Inositol lipids and cell proliferation

1987 • 315 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.

1989 • 262 citations

Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3.

1986 • 214 citations

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

1987 • 156 citations

Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets

1989 • 148 citations

Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor

1989 • 145 citations

Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine

1988 • 102 citations

Specific inhibitors of tyrosine-specific protein kinases: properties of 4-hydroxycinnamamide derivatives in vitro.

1989 • 100 citations

Platelet activating factor (PAF‐acether) promotes an early degradation of phosphatidylinositol‐4,5‐biphosphate in rabbit platelets

1983 • 95 citations

A role of calcium-activated, phospholipid-dependent protein kinase in platelet-activating factor-induced serotonin release from rabbit platelets

1982 • 91 citations

Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets

1983 • 77 citations

Ca2+ mobilization primes protein kinase C in human platelets. Ca2+ and phorbol esters stimulate platelet aggregation and secretion synergistically through protein kinase C.

1988 • 75 citations

K252a, a new inhibitor of protein kinase C, concomitantly inhibits 40K protein phosphorylation and seroton in secretion in a phorbol ester-stimulated platelets

1987 • 61 citations

Phosphorylation-dependent and -independent pathways of platelet aggregation

1989 • 46 citations

Inhibition of tyrosine protein kinase by synthetic erbstatin analogs.

1987 • 42 citations

Synthesis of erbstatin, a naturally occurring inhibitor of tyrosine-specific protein kinase

1987 • 18 citations