Implication of endogenous opioid system in the learned helplessness model of depression

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

A stereotaxic atlas of the rat brain

1967 • 4,710 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

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A stereotaxic atlas of the rat brain

1980 • 2,782 citations

The validity of animal models of depression

1984 • 1,365 citations

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

1980 • 705 citations

Behavioral depression produced by an uncontrollable stressor: Relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain

1981 • 659 citations

Enkephalin may mediate euphoria and drive-reduction reward

1977 • 450 citations

Animal models of depression: An overview

1990 • 425 citations

Learned helplessness in the rat: Time course, immunization, and reversibility.

1975 • 285 citations

Neurochemical basis of the action of antidepressants on learned helplessness

1980 • 253 citations

β-Endorphin-Induced Changes in Schizophrenic and Depressed Patients

1977 • 253 citations

Animal Models in Psychopharmacology

1991 • 216 citations

Depression: A Psychobiological Synthesis

1985 • 203 citations

Experiments in Personality

1964 • 195 citations

Serotonin neurons in nucleus raphe dorsalis and paragigantocellularis of the cat contain enkephalin.

1981 • 180 citations

Animal Models in Psychopharmacology

1991 • 175 citations

Reversal of learned helplessness by imipramine.

1979 • 153 citations

POSSIBLE ANTIDEPRESSIVE EFFECTS OF OPIOIDS: ACTION OF BUPRENORPHINE

1982 • 149 citations

β-Endorphin-Like Immunoreactivity in Cerebrospinal Fluid and Plasma of Patients with Schizophrenia and Other Neuropsychiatric Disorders

1979 • 147 citations

Interaction of tricyclic antidepressants with opiate receptors

1980 • 139 citations

Learned helplessness, inactivity, and associative deficits: Effects of inescapable shock on response choice escape learning.

1980 • 132 citations

Behavioral Pharmacology of 5-ht

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Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid δ and dopamine D1 receptor stimulation

1992 • 125 citations

Additivity of neurochemical changes in learned helplessness and imipramine

1982 • 110 citations

Reversal of helpless behavior in rats by putative 5-HT1A agonists

1988 • 108 citations

Opioid receptors and endogenous opioid peptides

1991 • 107 citations

Escape deficits induced by uncontrollable stress: Antagonism by dopamine and norepinephrine agonists

1980 • 93 citations

Influence of naloxone and methysergide on the analgesic effect of clomipramine in rats

1981 • 88 citations

Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective ? and ? opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes

1988 • 87 citations

Influence of control of shock on subsequent shock-elicited aggression.

1972 • 86 citations

Association of beta-endorphin with specific clinical symptoms of depression

1992 • 82 citations

Localization of substance P- and enkephalin-like like immunoreactivity in relation to catecholamine-containing cell bodies in the cat dorsolateral pontine tegmentum: An immunofluorescence study

1983 • 81 citations

Possible involvement of opiate receptors in the pharmacological profiles of antidepressant compounds

1984 • 80 citations

Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline

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Clinical antidepressant activity of cyclazocine—a narcotic antagonist

1970 • 74 citations

Opioids in mental illness: theories, clinical observations, and treatment possibilities.

1982 • 66 citations

The opiate antagonist naloxone modifies the effects of electroconvulsive shock (ECS) on respiration, blood pressure and heart rate

1979 • 65 citations

Loss of rat cerebral cortical opiate receptors following chronic desimipramine treatment

1982 • 62 citations

Opioid δ agonists and endogenous enkephalins induce different emotional reactivity than μ agonists after injection in the rat ventral tegmental area

1991 • 62 citations

ANTIMANIC, ANTIDEPRESSANT, AND ANTIPANIC EFFECTS OF OPIATES: CLINICAL, NEUROANATOMICAL, AND BIOCHEMICAL EVIDENCE

1982 • 61 citations

Noradrenergic and opioid mediation of tricyclic-induced reversal of escape deficits caused by inescapable shock pretreatment in rats

1986 • 56 citations

Influence of naloxone on antidepressant drug effects in the forced swimming test in mice

1984 • 55 citations

Depression. A Psychobiological Synthesis

1986 • 53 citations

Enkephalin Degrading Enzyme Inhibitors: A Physiological Way to New Analgesics and Psychoactive Agents

1986 • 48 citations

Studies in the mechanism of action of serotonin precursors in depression.

1984 • 45 citations

Effect of mixed (RB 38A) and selective (RB 38B) inhibitors of enkephalin degrading enzymes on a model of depression in the rat

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New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties

1989 • 43 citations

Therapeutic applications and mechanisms of action of monoamine oxidase inhibitor and heterocyclic antidepressant drugs.

1985 • 42 citations

Pharmacokinetic patterns of repeated administration of antidepressants in animals. I. Implications for antinociceptive action of clomipramine in mice.

1988 • 40 citations

The involvement of endogenous opiate systems in learned helplessness and stress-induced analgesia

1987 • 32 citations

Involvement of endogenous enkephalins in the mouse ‘behavioral despair’ test

1984 • 31 citations

Chronic blockade of D2 but not D1 dopamine receptors facilitates behavioural responses to endogenous enkephalins, protected by kelatorphan, administered in the accumbens in rats

1990 • 30 citations

The nature of the activity deficit produced by inescapable shock

1982 • 28 citations

Characterisation of two probes for the localisation of enkephalinase in rat brain: [3H]thiorphan and a 125I-labeled monoclonal antibody

1987 • 23 citations

Effects of some narcotics and antagonists on synaptosomal 3H-norepinephrine uptake

1972 • 22 citations

The effect of electroconvulsive therapy on endorphins in depression

1988 • 22 citations

Naltrexone prevents footshock-induced performance deficit in rats

1984 • 19 citations

Kelatorphan, a potent enkephalinases inhibitor, and opioid receptor agonists DAGO and DTLET, differentially modulate self-stimulation behaviour depending on the site of administration

1989 • 18 citations

Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice

1990 • 14 citations

Relationship Between Emotivity Level and Susceptibility to the Learned Helplessness Model of Depression in the Rat

1991 • 14 citations

Theophylline distribution kinetics analyzed by reference to simultaneously injected urea and inulin.

1987 • 13 citations

Beta-endorphine-induced changes in schizophrenic and depressed patients

1979 • 8 citations

Possible antidepressant activity of methadone

1982 • 7 citations