Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice

PHARMACOLOGICAL EFFECTS PRODUCED BY INTRACEREBRAL INJECTION OF DRUGS IN THE CONSCIOUS MOUSE

1957 • 1,523 citations

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

1980 • 705 citations

On the specificity of naloxone as an opiate antagonist

1979 • 611 citations

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

1981 • 503 citations

Time‐dose relationships for locomotor activity effects of morphine after acute or repeated treatment

1972 • 439 citations

The C-Fragment of β-Lipotropin: An Endogenous Neuroleptic or Antipsychotogen?

1976 • 427 citations

ICI 174864: A highly selective antagonist for the opioid Δ-receptor

1984 • 361 citations

Effects of morphine on striatal dopamine metabolism: Possible mechanism of its opposite effect on locomotor activity in rats and mice

1974 • 188 citations

Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.

1980 • 182 citations

Selective antagonists at the opiate delta-receptor

1982 • 170 citations

Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes

1984 • 168 citations

Mu opioid receptor involvement in enkephalin activation of dopamine neurons in the ventral tegmental area.

1987 • 151 citations

Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor.

1986 • 143 citations

Participation of both ‘enkephalinase’ and aminopeptidase activities in the metabolism of endogenous enkephalins

1983 • 140 citations

Inhibition of enkepha,in metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor

1983 • 139 citations

Comparison of the effects of morphine on locomotor activity, analgesia and primary and protracted physical dependence in six mouse strains.

1977 • 138 citations

Selective Protection of Methionine Enkephalin Released from Brain Slices by Enkephalinase Inhibition

1981 • 123 citations

Identification of aminopeptidase M as an enkephalin-inactivating enzyme in rat cerebral membranes

1985 • 117 citations

Naloxone reduces social and exploratory activity in the rat

1980 • 103 citations

Characterization of aminopeptidases responsible for inactivating endogenous (Met5)enkephalin in brain slices using peptidase inhibitors and anti-aminopeptidase M antibodies.

1986 • 103 citations

Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord.

1986 • 99 citations

Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective ? and ? opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes

1988 • 87 citations

In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain

1985 • 87 citations

New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties

1985 • 82 citations

Electroencephalographic and behavioral effects of D-ala2-methionine-enkephalinamide and morphine in the rat.

1978 • 80 citations

Mixed depressant and stimulant actions of morphine and their relationship to brain acetylcholine

1976 • 71 citations

evaluation of the opiate delta receptor antagonist ICI 154, 129

1982 • 66 citations

Dissociated effects of inhibitors of enkephalin-metabolising peptidase or naloxone on various nociceptive responses

1986 • 62 citations

The effects of low doses of morphine on the activity of dopamine-containing cells and on behavior

1982 • 61 citations

Behavioral activating effects of opiates and opioid peptides.

1980 • 54 citations

Endogenous enkephalin modulation of dopamine neurons in ventral tegmental area

1986 • 53 citations

Effects of humoral modulators and naloxone on morphine-induced changes in the spontaneous locomotor activity of the rat

1976 • 52 citations

Blockade of endogenous opiates reduces activity in the rat

1981 • 49 citations

Behavioral effects of opioid peptides selective for mu or delta receptors. II. Locomotor activity in nondependent and morphine-dependent rats.

1986 • 39 citations

MU and delta opioid receptors control differently the horizontal and vertical components of locomotor activity in mice

1989 • 38 citations

Effects of intraventricular morphine and enkephalins on locomotor activity in nondependent, morphine-dependent and postdependent rats.

1981 • 36 citations

Antagonism of morphine by long acting narcotic antagonists

1974 • 33 citations

Biphasic effects of a potent enkephalin analogue (d-Met2,Pro5)-enkephalinamide and morphine on locomotor activity in mice

1980 • 30 citations

Protection of enkephalins from enzymatic degradation utilizing selective metal-chelating inhibitors

1983 • 26 citations

Role of endogenous enkephalins in locomotion evidenced by acetorphan, an "enkephalinase" inhibitor.

1987 • 24 citations

Naloxone specifically blocks the linear locomotion in mice

1985 • 22 citations

Neurologic deficits and neuronal injury in rats resulting from nonopioid actions of the delta opioid receptor antagonist ICI 174864.

1988 • 20 citations

Naloxone-reversible effects of d-Ala2-Met5-enkephalinamide-induced behavioral activity in rats

1980 • 16 citations

Enkephalin-degrading dipeptidylaminopeptidase: characterization of the active site and selective inhibition.

1986 • 13 citations

Potent inhibition of cerebral aminopeptidases by carbaphethiol, a parenterally active compound

1988 • 9 citations